Alasdair Santini

ORCID: 0000-0003-2281-2133
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About
Contact & Profiles
Research Areas
  • Orthopaedic implants and arthroplasty
  • Total Knee Arthroplasty Outcomes
  • Orthopedic Infections and Treatments
  • COVID-19 and healthcare impacts
  • Trauma and Emergency Care Studies
  • Cardiac, Anesthesia and Surgical Outcomes
  • Osteoarthritis Treatment and Mechanisms
  • Bone fractures and treatments
  • Urinary Bladder and Prostate Research
  • Urinary Tract Infections Management
  • Pelvic and Acetabular Injuries
  • Sympathectomy and Hyperhidrosis Treatments
  • Botulinum Toxin and Related Neurological Disorders
  • Myofascial pain diagnosis and treatment
  • Musculoskeletal synovial abnormalities and treatments
  • Prostate Cancer Diagnosis and Treatment
  • Tendon Structure and Treatment
  • Climate Change and Health Impacts
  • Sports injuries and prevention
  • Knee injuries and reconstruction techniques
  • Global Health and Surgery
  • Orthopedic Surgery and Rehabilitation
  • Radiation Dose and Imaging
  • Hip disorders and treatments
  • Pelvic floor disorders treatments

Aintree University Hospitals NHS Foundation Trust
2020-2024

University of Liverpool
2005-2024

Royal Liverpool University Hospital
2005-2021

Royal Liverpool and Broadgreen University Hospital NHS Trust
2001-2019

Northern General Hospital
2000

Background: A recent report has suggested that local injection of botulinum toxin type is an effective method treatment for chronic tennis elbow. The thought to provide temporary paralysis the painful common extensor origin, thereby allowing a healing response occur. To test this theory, we performed double-blind, randomized, controlled, pilot trial comparing injections with those placebo (normal saline solution) in Methods: Forty patients history elbow which all conservative measures,...

10.2106/jbjs.d.01896 article EN Journal of Bone and Joint Surgery 2005-03-01

INTRODUCTION The aim of this study was to compare the functional outcome between first and second knee replacement in patients undergoing staged bilateral total arthroplasty. METHODS We identified 64 who had replacements at least one year postoperative studies. Data on pain scores, walking ability, use aids, range movement, instability, muscle strength, WOMAC® (Western Ontario McMaster Universities) SF-12 (Short Form 12) American Knee Society radiological scores length hospital stay (LOS)...

10.1308/147870811x13137608454803 article EN Annals of The Royal College of Surgeons of England 2011-10-01

Background: A recent report has suggested that local injection of botulinum toxin type is an effective method treatment for chronic tennis elbow. The thought to provide temporary paralysis the painful common extensor origin, thereby allowing a healing response occur. To test this theory, we performed double-blind, randomized, controlled, pilot trial comparing injections with those placebo (normal saline solution) in Methods: Forty patients history elbow which all conservative measures,...

10.2106/00004623-200503000-00004 article EN Journal of Bone and Joint Surgery 2005-03-01

Purpose: A stiff total knee replacement can severely limit a patient’s post-operative function, but there remain few prospective trials identifying those patients at risk, nor the efficacy of manipulation. We analysed our prospectively collected database to assess predictors stiffness and outcomes following Methods: Using arthroplasty data, including preoperative range movement, SF-12 (physical mental) The Western Ontario McMaster Universities Arthritis Index (WOMAC) scores, requiring...

10.1177/2309499018802971 article EN cc-by-nc Journal of orthopaedic surgery 2018-09-01

Postoperative urinary retention necessitating catheterization after major lower limb arthroplasty surgery adds to the patients' postoperative discomfort and increases risk of tract infection with potential transient bacteraemia seeding prosthetic joints. Preoperative evaluation patients symptoms may help identify at-risk International Prostate Symptoms Score (IPSS) has been used as a screening tool quantify severity in males. A prospective cohort 303 undergoing total hip or knee was...

10.1177/2309499019868670 article EN cc-by-nc Journal of orthopaedic surgery 2019-08-26

To compare the outcomes of three knee arthroplasty design philosophies and surface tribology.• A zirconium-surfaced, bicruciate-stabilised implant designed to mimic kinematic movement improve flexion outcomes;• cobalt-chrome surfaced, multi-radius with built-in femoral external rotation aid balancing patella tracking through a deeper trochlea groove;• single-radius on conformity, particularly within patello-femoral joint.313 replacements - 103 Journey II, Genesis II 107 Profix were...

10.1177/10225536231169572 article EN cc-by-nc Journal of orthopaedic surgery 2023-01-01

Degradation of articular cartilage is the defining feature end-stage osteoarthritis (OA) with osteophytes, subchondral sclerosis, malalignment and joint space narrowing being additional indicators advanced disease. Obesity, older age female gender are OA risk factors. Differing degrees synovitis observed in OA, soft tissue traumatic injuries knee. The synovium also subject to systemic, enhanced lipids inflammatory mediators characteristic obesity. Synovial cellular composition changes...

10.1016/j.dib.2022.108082 article EN cc-by Data in Brief 2022-03-21

Abstract The Journey-I total knee replacement was designed to improve kinematics but had several complications including early dislocation. Journey-II modification introduced reduce these while maintaining high function. To assess whether the modified prosthesis has succeeded in its designers aims, we undertook an observational study of prospectively recorded data analyze and compare two knees. A 217 129 knees were identified from department's collated registry assessed at 1 year by a...

10.1055/s-0040-1718599 article EN The Journal of Knee Surgery 2020-10-27

Abstract Background Oxidized zirconium (OxZr) has been introduced as an alternative bearing for femoral components in Total Knee Arthroplasty (TKA). It a ceramic-like oxide outer layer with low coefficient of friction. Early studies have found OxZr TKA to incidence early failure young high demand patients. Currently no study reported on the outcome these implants beyond ten years. Objectives The purpose our was present in-depth 15-year survival analysis cemented Profix II TKA. Study Design...

10.1302/1358-992x.2023.13.003 article EN Orthopaedic Proceedings 2023-08-07
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