- Epilepsy research and treatment
- Traumatic Brain Injury Research
- Memory and Neural Mechanisms
- Dementia and Cognitive Impairment Research
- Cognitive Functions and Memory
- Cardiac Arrest and Resuscitation
- Memory Processes and Influences
- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Childhood Cancer Survivors' Quality of Life
- Neurobiology of Language and Bilingualism
- Child and Adolescent Psychosocial and Emotional Development
- Sleep and related disorders
- Infant Development and Preterm Care
- Pharmacological Effects and Toxicity Studies
- Adolescent and Pediatric Healthcare
- Sleep and Wakefulness Research
- Neuroscience and Neuropharmacology Research
- Neuroscience of respiration and sleep
- Neonatal and fetal brain pathology
- Attention Deficit Hyperactivity Disorder
- Identity, Memory, and Therapy
- Child and Animal Learning Development
- Reading and Literacy Development
- Family and Disability Support Research
The University of Sydney
2016-2025
ARC Centre of Excellence in Cognition and its Disorders
2013-2024
Macquarie University
2002-2024
Australian Research Council
2013-2024
Children's Hospital at Westmead
2021
Royal Prince Alfred Hospital
2017
Sydney Children's Hospital
2002-2004
UNSW Sydney
2003
Objective: Children with epilepsy are at risk of specific cognitive deficits. We aimed to compare and characterize the memory function children childhood absence (CAE), frontal lobe (FLE) temporal (TLE). Methods: Epilepsy syndrome was identified by clinical data, seizure semiology, interictal ictal electroencephalogram (EEG). Seventy aged 6−18 years CAE, FLE or TLE had neuropsychological assessment including function. After adjusting for variables, results groups normative data were...
Frontotemporal dementia (FTD) is a neurodegenerative brain disorder that affects the frontal and temporal lobes predominantly. Impaired emotion recognition has been reported in two FTD subtypes: behavioral-variant (bvFTD) semantic (SD), but not investigated third subtype: progressive nonfluent aphasia (PNFA).Recognition of six basic facial emotions (anger, disgust, fear, sadness, surprise, happiness) was 41 patients (bvFTD = 16; SD 12; PNFA 13) 37 age- education-matched controls, using...
Patients with frontotemporal dementia (both behavioural variant [bvFTD] and semantic [SD]) as well those Alzheimer's disease (AD) show deficits on tests of face emotion processing, yet the mechanisms underlying these have rarely been explored. We compared groups patients bvFTD (n = 17), SD 12) or AD 20) to an age- education-matched group healthy control subjects 36) three processing tasks (Ekman 60, Emotion Matching Selection) found that all patient were similarly impaired. Analyses...
Patients with frontotemporal dementia (both behavioural variant [bvFTD] and semantic [SD]) as well those Alzheimer's disease (AD) show deficits on tests of face emotion processing, yet the mechanisms underlying these have rarely been explored. We compared groups patients bvFTD ( n = 17), SD 12) or AD 20) to an age- education-matched group healthy control subjects 36) three processing tasks (Ekman 60, Emotion Matching Selection) found that all patient were similarly impaired. Analyses...
<h3>Background and purpose</h3> Behavioural-variant frontotemporal dementia (bvFTD) Alzheimer9s disease (AD) patients experience behavioural emotion recognition alterations, yet understanding of how socioemotional processing is affected with progression minimal. Additionally, evidence suggests that bvFTD limited brain atrophy on neuroimaging at presentation (bvFTD-la) have a more benign course than those marked (bvFTD-ma). Longitudinal investigation these patients, however, lacking....
AbstractEpisodic thinking involves the ability to re-create past and construct future personal events, which contain event-specific (episodic) general (semantic) details. The richness of episodic thought for events improves as children move into adolescence. current study aims examine changes in establish cognitive underpinning these changes. Typically developing (n = 14) adolescents 15) were tested using an adapted version Child Autobiographical Interview (CAI) that required generation...
The capacity to remember self-referential past events relies on the integrity of a distributed neural network. Controversy exists, however, regarding involvement specific brain structures for retrieval recently experienced versus more distant events. Here, we explored how characteristic patterns atrophy in neurodegenerative disorders differentially disrupt remote recent autobiographical memory. Eleven behavioural-variant frontotemporal dementia, 10 semantic 15 Alzheimer's disease patients...
Prospective memory problems are common in patients with brain injury, but appropriate measures limited. The reliability and validity of the newly designed Royal Prince Alfred Memory Test (RPA-ProMem), which has three alternate versions, was investigated 20 healthy volunteers neurological everyday prospective problems. RPA-ProMem found to be easy score reliably (inter-rater = .90) its versions were well matched (delayed alternate-form .71). sensitivity patient deficits also supported. This...
Pediatric traumatic brain injury (TBI) places children at risk for deficits in working memory (WM; comprising a central executive [CE], and two storage systems: phonological loop [PL] visuospatial sketchpad [VSSP]), which is strongly related to attention academic skills childhood. This study aimed examine whether different components of WM can be improved following adaptive training (Cogmed) improvements generalize other cognitive (attention) (reading mathematics) with TBI. Twenty-seven...
Abstract Background There is a strong research imperative to investigate effective treatment options for adolescents and adults with autism spectrum disorder (ASD). Elevated social anxiety, difficulties functioning poor mental health have all been identified as core targets this group. While theoretical models posit bidirectionality between anxiety ASD deficits, few interventions targeted both domains concurrently. Of the two group previously conducted ASD, significant results only observed...
Summary: Purpose: In a previous investigation (Lah et al., 2004), we found deficits in retrograde memory patients who had undergone temporal lobectomy (TL). this study, set out to determine whether such are present before surgery with lobe epilepsy (TLE). Methods: Memory for public and autobiographic facts events was assessed focal left‐sided (n = 15) or right‐sided 14) TLE healthy control subjects 15). The impact of underlying cognitive on also examined. Results: Patients left demonstrated...
Summary Purpose: The rapid forgetting of information over long (but not short) delays (accelerated long‐term [ALF]) has been associated with temporal lobe epilepsy but idiopathic generalized (IGE). Long‐term memory formation (consolidation) is thought to demand an interaction between medial and neocortical networks, which could be disrupted by epilepsy/seizures themselves. present study investigates whether ALF in children IGE it relates severity. Methods: Sixty‐one (20 41 healthy controls...
<b><i>Background/Aims:</i></b> Carer burden has been associated with other carer-reported factors (e.g. depression), but less is known about the influence of more independent variables. We aimed to determine impact cognitive deficits, demographic variables and dementia subtype on carer burden. <b><i>Methods</i></b>: Patients Alzheimer's (n = 35) or frontotemporal lobar degeneration 61) underwent assessment anterograde memory, word generation,...
Sleep disordered breathing (SDB) has its peak incidence in early childhood, but research into the impact of disrupted sleep on learning and overnight memory consolidation been largely neglected this population. Hence, we aimed to determine if children with SDB show deficits declarative procedural memories compared healthy control (HC) children. Forty-nine aged 7–16 years (24 SDB, 25 HC) completed a cognitive battery, including two (one verbal, one visual) task. We manipulated level (three...