A5037252618- Ferroptosis and cancer prognosis
- Atherosclerosis and Cardiovascular Diseases
- Cancer-related molecular mechanisms research
- Seaweed-derived Bioactive Compounds
- Immune cells in cancer
- Macrophage Migration Inhibitory Factor
- Echinoderm biology and ecology
- Protein Tyrosine Phosphatases
- Phagocytosis and Immune Regulation
- Renin-Angiotensin System Studies
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
Qingdao University
2022-2025
Affiliated Hospital of Qingdao University
2022-2025
Carbonic anhydrase I (CA1) has been reported to be a diagnostic and therapeutic target for atherosclerosis (AS). This study aimed verify the essential role of CA1 in AS progression CA1-overexpressing mice. A ApoE [-/-] knock-in mouse model was constructed via CRISPR/Cas9-mediated genome engineering. then induced these transgenic mice administration high-fat diet, second group simultaneously received treatment with methazolamide (MTZ), carbonic inhibitor. Compared without overexpression, had...
Immune checkpoint blockade (ICB) has been recognized as a promising immunotherapy for colorectal cancer (CRC); however, most patients have little or no clinical benefit. This study aimed to develop novel cancer-immunity cycle–based signature stratify prognosis of with CRC and predict efficacy immunotherapy. samples from The Cancer Genome Atlas (TCGA) were used the training set, while RNA data Gene Expression Omnibus (GEO) sets real-time quantitative PCR (RT-qPCR) paired frozen tissues...
It has been reported that carbonic anhydrase I (CA1) is a target for the diagnosis and therapy of atherosclerosis (AS) since CA1 can promote AS aortic calcification. We also found methazolamide (MTZ), drug glaucoma treatment an inhibitor anhydrases, treat by inhibiting calcification in tissues. This study focused on therapeutic mechanism MTZ pathogenic AS. In this study, routine animal model was established ApoE−/− mice, which were treated with MTZ. The tissues analyzed using single‐cell...
Background Currently, a very small number of patients with colorectal cancer (CRC) respond to immune checkpoint inhibitor (ICI) treatment. Therefore, there is an urgent need investigate effective biomarkers determine the responsiveness ICI Recently, aberrant 5-methylcytosine (m 5 C) RNA modification has emerged as key player in pathogenesis cancer. Thus, we aimed explore predictive signature based on m C regulator–related genes for characterizing landscapes and predicting prognosis response...
Background Coagulation is critically involved in the tumor microenvironment, cancer progression, and prognosis assessment. Nevertheless, roles of coagulation-related long noncoding RNAs (CRLs) colorectal (CRC) remain unclear. In this study, an integrated computational framework was constructed to develop a novel lncRNA signature (CRLncSig) stratify CRC patients, predict response immunotherapy chemotherapy CRC, explore potential molecular mechanism. Methods samples from The Cancer Genome...