A5081887000- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
- Antimicrobial Resistance in Staphylococcus
- COVID-19 epidemiological studies
- SARS-CoV-2 and COVID-19 Research
- Bacterial Identification and Susceptibility Testing
- Vaccine Coverage and Hesitancy
- Streptococcal Infections and Treatments
- Helicobacter pylori-related gastroenterology studies
- Genomics and Phylogenetic Studies
- Infections and bacterial resistance
- Bacteriophages and microbial interactions
- Herbal Medicine Research Studies
- Legume Nitrogen Fixing Symbiosis
- Microbial infections and disease research
- Plant Pathogenic Bacteria Studies
- Influenza Virus Research Studies
- Mycobacterium research and diagnosis
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 detection and testing
- Viral Infections and Outbreaks Research
- Probiotics and Fermented Foods
- Antibiotic Use and Resistance
Fundación Ciencia and Vida
2023-2025
University of Nottingham Ningbo China
2025
Universidad Andrés Bello
2016-2022
Millennium Science Initiative
2020-2022
Agencia Nacional de Investigación y Desarrollo
2022
Wellcome Sanger Institute
2020
Clostridioides difficile infection (CDI) remains an urgent global One Health threat. The genetic heterogeneity seen across C. underscores its wide ecological versatility and has driven the significant changes in CDI epidemiology last 20 years. We analysed international collection of over 12,000 genomes spanning eight currently defined phylogenetic clades. Through whole-genome average nucleotide identity, pangenomic Bayesian analyses, we identified major taxonomic incoherence with clear...
Clostridium difficile is a Gram-positive spore-former bacterium and the leading cause of nosocomial antibiotic-associated diarrhea that can culminate in fatal colitis. During infection, C. produces metabolically dormant spores, which persist host recurrence infection. The surface spores seems to be key spore-host interactions persistence. proteome outermost exosporium layer has been determined, identifying two cysteine-rich proteins, CdeC CdeM. In this work, we explore contribution both...
is a Gram-positive and anaerobic bacterial species previously considered as uncultivable. Although little known about this
The burden of COVID-19 was heterogeneous, indicating that the effects this disease are synergistic with both other non-communicable diseases and socioeconomic status (SES), highlighting its syndemic character. While appearance vaccines moderated pandemic effects, their coverage heterogeneous too, when comparing different countries, populations within countries. Of note, once again SES appears to be a correlated factor. We analyzed publicly available data detailing percentage school-aged,...
<title>Abstract</title> Antimicrobial resistance (AMR) is projected to increase globally, yet the genomic traits and social determinants of health driving its trajectory are poorly understood. Here, we present first global-scale AMR forecasting analysis, integrating machine learning, Monte Carlo simulations modelling identify clinically relevant increase, key their over next 25 years. We analysed 45,645 bacterial genomes (including ESKAPE World Health Organisation high/critical priority...
Multilocus Sequence Typing (MLST) is a precise microbial typing approach at the intra-species level for epidemiologic and evolutionary purposes. It operates by assigning sequence type (ST) identifier to each specimen, based on combination of alleles multiple housekeeping genes included in defined scheme. The use MLST has multiplied due availability large numbers genomic sequences data public repositories. However, processing speed become problematic massive size modern datasets. Here, we...
Clostridium perfringens is the causative agent of many enterotoxic diseases in humans and animals, it present diverse environments (soil, food, sewage, water). Multilocus Sequence Typing (MLST) Whole Genome Sequencing (WGS) have provided a general approach about genetic diversity C. ; however, those studies are limited to specific locations often include reduced number genomes. In this study, 372 genomes from multiple sources were used assess phylogenetic relatedness pathogen. silico MLST...
Current efforts to understand the epidemiology, transmission dynamics and emergence of novel SARS-CoV-2 variants worldwide has enabled scientific community generate critical information aimed at implementing disease surveillance control measures, as well reduce social, economic health impact pandemic. Herein, we applied an epidemic model coupled with genomic analysis assess in Colombia. This allowed identify geographical distribution, Rt predict course pandemic considering current...
Clostridium difficile B1/NAP1/RT027/ST01 has been responsible for outbreaks of antibiotic-associated diarrhoea in clinical settings worldwide and is associated with severe disease presentations increased mortality rates. Two fluoroquinolone-resistant (FQR) lineages the epidemic strain emerged USA early 1990s disseminated trans continentally (FQR1 FQR2). However, it unclear when from where they entered Latin America (LA) whether isolates LA exhibit unique genomic features compared to other...
The third wave of the global health crisis attributed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus reached Colombia in March 2021. Over following 6 months, it was interpolated by manifestations popular disapproval actual political regime-with multiple protests sprouting throughout country. Large social gatherings seeded novel disease 2019 (COVID-19) variants big cities and propagated their facile spread, leading increased rates hospitalizations deaths.In this...
The endospore of Clostridioides difficile is the vehicle for transmission and persistence pathogen, and, specifically, exosporium first contact between host spore. underlying mechanisms that govern assembly in C. remain understudied, part due to difficulties obtaining pure soluble recombinant proteins exosporium. Understanding assembly’s molecular bases may be essential developing new therapies against infection.
Abstract Clostridioides difficile infection (CDI) remains an urgent global One Health threat. The genetic heterogeneity seen across C. underscores its wide ecological versatility and has driven the significant changes in CDI epidemiology last 20 years. We analysed international collection of over 12,000 genomes spanning eight currently defined phylogenetic clades. Through whole-genome average nucleotide identity, pangenomic Bayesian analyses, we identified major taxonomic incoherence with...
<title>Abstract</title> The burden of COVID-19 was heterogeneous, indicating that the effects this disease are synergistic with both other non-communicable diseases and socioeconomic status (SES), highlighting its syndemic character. While appearance vaccines moderated pandemic effects, their coverage heterogeneous too, when comparing different countries, populations within countries. Of note, once again SES appears to be a correlated factor. We analyzed publicly available data detailing...
Sellimonas intestinalis is a Gram positive and anaerobic bacterial species previously considered as uncultivable. Although little known about this Lachnospiraceae family member, its increased abundance has been reported in patients who recovered intestinal homeostasis after dysbiosis events. In context, the aim of work was taken advantage culturomics protocol that allowed recovery extremely oxygen-sensitive from faecal samples, which led to establishment an S. isolate. Whole genome...
ABSTRACT Clostridium paraputrificum is a gut microbiota member reported in several cases of bacteremia and coinfections. So far, only one genome sequence C. (AGR2156) isolate available. Here, we present the draft strain 373-A1, isolated from stools patient with difficile infection.
Abstract Background The burden of COVID-19 has been heterogeneous, indicating that the effects this disease are synergistic with both other non-communicable diseases and socioeconomic status (SES), high-lighting its syndemic character. While appearance vaccines moderated pandemic effects, their coverage also when comparing different countries, populations within countries. Of note, once again SES appears to be a correlated factor. Methods To examine relationship between vaccination coverage,...
Abstract Clostridioides difficile is an obligate anaerobe spore-forming, Gram-positive, pathogenic bacterium, considered the leading cause of nosocomial diarrhea worldwide. Recent studies have attempted to understand biology outer-most layer C. spores, exosporium, which believed contribute early interactions with host. The fundamental role cysteine-rich proteins CdeC and CdeM has been described. However, molecular details behind mechanism exosporium assembly are missing. underlying...
ABSTRACT Multilocus Sequence Typing (MLST) is a precise microbial typing approach at the intra-species level for epidemiological and evolutionary purposes. It operates by assigning sequence type (ST) identifier to each specimen, based on combination of allelic sequences obtained multiple housekeeping genes included in defined scheme. The use MLST has multiplied due availability large numbers genomic data public repositories. However, processing speed become problematic datasets’ massive...