A5071773421- Hippo pathway signaling and YAP/TAZ
- Wnt/β-catenin signaling in development and cancer
- Gene expression and cancer classification
- Bioinformatics and Genomic Networks
- Cancer Immunotherapy and Biomarkers
- Genomics and Chromatin Dynamics
- Cancer Genomics and Diagnostics
- Gene Regulatory Network Analysis
- Immunotherapy and Immune Responses
- Cellular Mechanics and Interactions
- Vascular anomalies and interventions
- Central Venous Catheters and Hemodialysis
- ATP Synthase and ATPases Research
- Obstructive Sleep Apnea Research
- Orthopedic Surgery and Rehabilitation
- Heat shock proteins research
- Mitochondrial Function and Pathology
- Developmental Biology and Gene Regulation
- Cancer Cells and Metastasis
- Dysphagia Assessment and Management
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Vascular Procedures and Complications
- Nanoplatforms for cancer theranostics
- Fibroblast Growth Factor Research
Boston University
2017-2025
University of Pennsylvania Health System
2022
University School
2019
University of Wisconsin–Madison
2016-2017
Abstract Basal-like breast cancers exhibit distinct cellular heterogeneity that contributes to disease pathology. In this study we used a genetic mouse model of basal-like cancer driven by epithelial-specific inactivation the Hippo pathway-regulating LATS1 and LATS2 kinases elucidate epithelial-stromal interactions. We demonstrate carcinoma initiation in is accompanied accumulation cancer-associated fibroblasts macrophages dramatic extracellular matrix remodeling, phenocopying stromal...
Abstract Basal-like breast cancers, an aggressive cancer subtype that has poor treatment options, are thought to arise from luminal mammary epithelial cells undergo basal plasticity through poorly understood mechanisms. Using genetic mouse models and ex vivo primary organoid cultures, we show conditional co-deletion of the LATS1 LATS2 kinases, key effectors Hippo pathway signaling, in mature promotes development Krt14 Sox9-expressing basal-like carcinomas metastasize over time. Genetic...
Molecular events that drive the development of precancerous lesions in bronchial epithelium, which are precursors lung squamous cell carcinoma (LUSC), poorly understood. We demonstrate disruption epithelial cellular polarity, via conditional deletion apical determinant Crumbs3 (Crb3), initiates and sustains airway pathology. The loss Crb3 adult luminal epithelium promotes uncontrolled activation transcriptional regulators YAP TAZ, stimulate intrinsic signals promote plasticity paracrine...
Downregulation of the cylindromatosis (CYLD) tumor suppressor has been associated with breast cancer development and progression. Here, we report a critical role for CYLD in maintaining phenotype mammary epithelial cells vitro vivo. downregulation or inactivation induced an to mesenchymal transition that was dependent on concomitant activation transcription factors Yes-associated protein (YAP)/transcriptional coactivator PDZ-binding motif (TAZ) transforming growth factor beta...
The identification of genetic alteration combinations as drivers a given phenotypic outcome, such drug sensitivity, gene or protein expression, and pathway activity, is challenging task that essential to gaining new biological insights discovering therapeutic targets. Existing methods designed predict complementary outcomes lack analytical flexibility, including the support for joint analyses multiple genomic types, somatic mutations copy number alterations, scoring functions, rigorous...
Abstract Approximately 4-7% of non-small cell lung cancers (NSCLC) harbor the EML4-ALK chromosomal rearrangement. ALK has been identified as a molecular driver cancer and inhibitors have developed for clinical use. We confirmed high expression EGFR in EML4-ALK-positive lines (H3122 H2228). Recognizing capacity both signaling to regulate tumor growth, we investigated effects co-inhibition on proliferation migration cells vitro. also examined anti-tumor effect xenograft mouse models. Cell was...
Inference of biological network structures is often performed on high-dimensional data, yet hindered by the limited sample size high throughput “omics” data typically available. To overcome this challenge, referred to as “small n , large p problem,” we exploit known organizing principles networks that are sparse, modular, and likely share a portion their underlying architecture. We present SHINE — S tructure Learning for Hi erarchical Ne tworks—a framework defining data-driven structural...
The transulnar approach (TUA) has been proposed as a safe alternative to the more established transradial (TRA) for cardiac catheterization. However, no study assessed anatomy and variability of ulnar artery using angiography.
Abstract Radiation therapy (RT) may enhance tumor susceptibility to immune response. We and others have observed a cooperative interaction between RT various immunotherapies, which appears dependent on the relative sequencing of each therapy. reported synergistic antibody-dependent cell-mediated cytotoxicity (ADCC) response tumor-specific monoclonal antibodies (mAb) in murine melanoma. enhanced effect when immunotherapy is administered 6-10 days after compared administration 1-5 or 11-15....
Abstract Identifying complementary genetic drivers of a given phenotypic outcome is challenging task that important to gaining new biological insight and discovering targets for disease therapy. Existing methods aimed at achieving this lack analytical flexibility. We developed Candidate Driver Analysis or CaDrA, framework identify functionally-relevant subsets binary genomic features that, together, are associated with specific interest. evaluate CaDrA’s sensitivity specificity...
Abstract Basal-like breast cancers, an aggressive cancer subtype that has poor treatment options, are thought to arise from luminal mammary epithelial cells but undergo plasticity a basal-like state upon transformation. Identifying cellular mechanisms underlying this luminal-basal will allow improved understanding of the pathogenesis cancers. The Hippo signaling pathway, important cell fate regulator across many tissues, been implicated in development. Central tumor suppressor kinases LATS1...
Abstract Introduction Oculopharyngeal muscular dystrophy (OPMD) is an autosomal-dominant, late-onset, and progressive disease characterized by ptosis dysphagia, sometimes proximal limb weakness gait abnormalities. It often presents in patients their 50s. The functional decline of the pharyngeal muscles results feeding difficulties aspiration; however, may also have risk nocturnal hypoventilation sleep apnea, complicated variable airway obstruction compliance. Report Cases: Using...
ABSTRACT Network analysis offers a powerful technique to model the relationships between genes within biological regulatory networks. Inference of network structures is often performed on high-dimensional data, yet hindered by limited sample size high throughput “omics” data typically available. To overcome this challenge, we exploit known organizing principles networks that are sparse, modular, and likely share large portion their underlying architecture. We present SHINE - S tructure...