A previous study demonstrated that a dose effect between 1.6 and 4.0 mg/kg bwt of omeprazole per os s.i.d. is present in the treatment equine gastric ulceration. In same study, healing glandular ulceration appeared inferior to squamous However, several limitations were recognised further investigation warranted.To investigate presence relationship under conditions may favour efficacy such as administration prior exercise after brief fast, potential differences response therapy.A blinded,...

Background To date, risk factors for equine glandular gastric disease (EGGD) have not been described in Thoroughbred racehorses. Objectives determine management associated with EGGD, identify clinical signs affected horses, and compare these to squamous (ESGD). Animals The study was carried out on 109 racehorses from 8 training yards (3 the United Kingdom 5 Australia). Methods Gastroscopic examination alongside a questionnaire regarding management, feeding, exercise, health. Results...

Summary Reasons for performing the study Studies on omeprazole have reported that doses as low 0.7 mg/kg bwt per os are potent suppressors of acid production. Yet, to date, no studies compared treatment efficacy different in clinical cases equine gastric ulceration. Furthermore, been performed compare healing response squamous and glandular mucosa suppression therapy. Objectives To compare: 1) 2 primary ulceration; 2) ulceration Study design A blinded, randomised, dose–response trial....

Foreword The European College of Equine Internal Medicine (ECEIM) consensus statement recently made the distinction between disease squamous mucosa (Equine Squamous Gastric Disease; ESGD) and glandular Glandular EGGD) ( Sykes et al, 2015a ). Since its publication, a number reports have furthered understanding pathology management EGGD, such that new clinical guidelines for this condition were considered necessary. following are views subject specialist representing authors ECEIM statement,...

Summary Background Previous studies have demonstrated a poor response to healing of gastric glandular lesions with oral omeprazole and other medications. Objectives To evaluate the efficacy two novel treatments (misoprostol [M] combined omeprazole‐sucralfate [OS]) in horses for disease. Study design Prospective, clinical study. Methods Sixty‐three sports grade >1/4 disease were identified by gastroscopy. Horses received either 5 μg/kg misoprostol per os BID 1 h prior feeding or...

The purposes of the study were to describe ultrasonographic appearance and measurements normal bovine eye, compare those reported previously for cadaveric eyes differences between ocular dimensions Holstein Friesian Jersey cattle. Sixty transpalpebral examinations performed on 30 adult cows, 16 8 cows. Transpalpebral images obtained with a 10 MHz linear transducer in both horizontal vertical imaging planes. structures within eye is similar that other species, although ciliary artery was...

Echocardiography is a non-invasive method for assessment of the ovine and caprine heart. Complete reference ranges cardiac dimensions time indices both species are not currently available reliability these measurements has been evaluated. The objectives this study to report reliability, normal in large group adult sheep goats. Fifty-one forty goats were recruited. Full echocardiographic examinations performed standing unsedated animal. All animals underwent echocardiography four times...

Summary Reasons for performing the study A recent suggested that duration of acid suppression achieved with once‐daily administration omeprazole is as short 12 h and prior to exercise may be superior compared at other times day in treatment equine gastric ulcer syndrome ( EGUS ). Objectives The primary objective was investigate whether resulted better healing post exercise. secondary differences between response squamous glandular therapy. Study design randomised, blinded, clinical trial....

Primary care guidelines provide a reference point to guide clinicians based on systematic review of the literature, contextualised by expert clinical opinion. These develop modification GRADE framework for assessment research evidence (vetGRADE) and applied this range scenarios regarding use analgesic agents. Key produced panel included recommendations that horses undergoing routine castration should receive intratesticular local anaesthesia irrespective methods adopted NSAIDs prior surgery...

Abstract Background Equine glandular gastric disease (EGGD) is common in domesticated horses and can be challenging to treat. Oral omeprazole (ORLO) used widely but the clinical response frequently poor. Objectives To compare rates of EGGD healing improvement between ORLO a long‐acting injectable preparation (LAIO). Study design Retrospective study. Methods The case records gastroscopy images presenting masked for peer review over 12‐month period were reviewed, with blindly assessed by one...

The aims of this study were to assess the repeatability and reproducibility transabdominal ultrasonography intestinal wall thickness in adult Thoroughbred horses (n = 8). Ultrasonographic cineloops captured by one examiner from each horse for five consecutive days. During examination at least three obtained different tract locations. Measurements performed separate observers measured on occasions evaluate short-term repeatability. measurements duodenum (0.3 +/- 0.04 cm), jejunum (0.29 0.05...

Equine squamous gastric disease (ESGD) is a highly prevalent in horses, particularly elite athletes. Some horses respond slowly, or fail to respond, the licensed treatment, oral omeprazole (ORLO).To compare rates of ESGD healing and improvement between ORLO long-acting injectable preparation (LAIO).Retrospective clinical study.The case records gastroscopy images presenting Rainbow Hospital over 12-month period were reviewed, with being reviewed blind by one authors (David Rendle). Treatment...

Summary Cases with a history of colic due to large colonic impaction were recruited retrospectively assess the treatment efficacy and complications oral parenteral fluid therapy regimes for correction primary colon impactions. Oral isotonic fluids had been administered at varying intervals following initial magnesium sulphate water. There was no significant difference in complication rates between groups. Considering clearance, hourly administration appears be most appropriate regime those...

Equine gastric glandular disease (EGGD) is a common condition, for which the underlying pathophysiology undetermined. Endoscopic mucosal biopsies have been proposed as method adapting therapy.To evaluate diagnostic information obtained from endoscopic biopsies.Prospective, experimental study.Twenty-one horses undergoing elective humane slaughter were subjected to gross examination of mucosa. Glandular pathology was graded using EGUS Council guidelines digital camera images. Mucosal...

Interest in Equine Gastric Ulcer Syndrome (EGUS) has recently increased part due to a growing awareness of the differences between squamous and glandular disease. The pathophysiology epidemiology disease are different it been shown that response gastric ulceration monotherapy with omeprazole is poor. Given these recommended specific treatment guidelines be formulated for equine adjunctive therapies investigated. Along lines suggested addition antimicrobials may enhance healing. objective...

Equine gastric ulcer syndrome is an important cause of morbidity in weanling foals. Many foals are asymptomatic, and the development inexpensive screening test to ensure early diagnosis desirable. The objective this study was determine diagnostic accuracy blood sucrose for EGUS 45 were studied 7 days before 14 after weaning. lesions (GL); glandular (GDL); squamous (SQL) clinically significant (CSL) at 90 min administration 1 g/kg via nasogastric intubation assessed using ROC curves...

Equine gastric ulcer syndrome (EGUS) is common in adult horses, particularly those involved performance disciplines. Currently, detection of EGUS by gastroscopy the only reliable ante mortem method for definitive diagnosis; however it unsuitable as a screening test because expensive, time consuming, and not readily available to most veterinarians. Sucrose permeability testing represents simple, economical alternative purposes, feasibility this approach horse has been previously reported. The...

Background : Hypertonic saline and hydroxyethyl starches have been proposed as alternatives to isotonic crystalloids for reversal of hypovolemia in horses with colic. However, no direct comparison these fluids has performed a clinical setting. Hypothesis Preoperative administration hypertonic or pentastarch would produce similar effects on intra operative hemodynamics Animals Thirty requiring colic surgery were enrolled this prospective, randomized, open‐label trial. Inclusion criteria owner...

Hypertonic saline and hydroxyethyl starches have been proposed as alternatives to isotonic crystalloids for reversal of hypovolemia in horses with colic. However, no direct comparison these fluids has performed a clinical setting.Preoperative administration hypertonic or pentastarch would produce similar effects on intra operative hemodynamics colic.Thirty requiring colic surgery were enrolled this prospective, randomized, open-label trial. Inclusion criteria owner consent, at least 2 3...

The aims of this study were to establish a normal reference range (mean ± 2 SD ) and assess reliability renal dimensions obtained using transabdominal ultrasonography in T horoughbred horses ( n = 7). A minimum three ultrasonographic cineloops from each intercostal space the left paralumbar fossa by two observers daily for consecutive days. Renal length, width, thickness cortex, medulla, pelvic obtained. Measurements undertaken both observers, who unaware prior measurements, reproducibility...