A5085355499- Biosensors and Analytical Detection
- Advanced biosensing and bioanalysis techniques
- CRISPR and Genetic Engineering
- Advanced Photocatalysis Techniques
- Bacteriophages and microbial interactions
- Nanopore and Nanochannel Transport Studies
- Cytomegalovirus and herpesvirus research
- Bacterial biofilms and quorum sensing
- Innovative Microfluidic and Catalytic Techniques Innovation
- Fuel Cells and Related Materials
- Ga2O3 and related materials
- Perovskite Materials and Applications
- SARS-CoV-2 detection and testing
- RNA and protein synthesis mechanisms
- Ion-surface interactions and analysis
- Microbial Community Ecology and Physiology
- Transition Metal Oxide Nanomaterials
- Copper-based nanomaterials and applications
- ZnO doping and properties
- Melanoma and MAPK Pathways
- Quantum Dots Synthesis And Properties
- Advanced Chemical Sensor Technologies
Hainan University
2018-2025
Hainan Medical University
2025
Shanghai University of Engineering Science
2020-2021
NiWO 4 /WO 3 heterojunction microspheres are prepared by a hydrothermal and subsequent impregnation process, the formation of Z-scheme significantly improves visible light degradation performance MB dyes.
The real-time microbial growth curve system provides fully automated, high-throughput monitoring of with comparable precision to conventional microplate readers, though it offers longer times.
Abstract Clinical pathogen diagnostics detect targets by qPCR (but with low sensitivity) or blood culturing time-consuming). Here we leverage a dual-stem-loop DNA amplifier to enhance non-specific collateral enzymatic cleavage of an oligonucleotide linker between fluophore and its quencher CRISPR-CasΦ, achieving ultrasensitive target detection. Specifically, the pathogens are lysed release DNA, which binds complementary gRNA in CRISPR-CasΦ activate DNA-cleavage capability CasΦ, enabling CasΦ...
Nanopore technology is promising for the next-generation of nucleic acid–based diagnosis. However, sequence reservation could still be hardly achieved in low-concentration. Herein, we propose a trypsin-activated catalysis reaction amplified detection, which substantially improves sensitivity nanopore technique. The proposed trypsin-amplified sandwich assay (tNASA) contribute to approximately 100 000 times higher based on acid probe design. Remarkably, tNASA capable attomolar and single cell...
Field-deployable detectors of disease biomarkers provide a simple and fast analysis clinical specimens. However, most the existing field-deployable diagnostics have poor sensitivity are not suitable for detection with low abundance. Herein, we report highly sensitive rapid colorimetric readout paper-based assay pathogen by integrating unique collateral activity Cas12a-activated universal detector (CUFD). The effect Cas12a results in nonspecific destruction fluorophore biotin-labeled ssDNA...
CdS/Zn 3 (PO 4 ) 2 Z-scheme heteronanostructures were prepared through a simple hydrothermal route and precipitation methods, the efficiency for photocatalytic degradation of MB solution can be improved greatly.
Abstract Pathogens are one of the important factors affecting national economic construction. An ideal detection system for pathogen control with excellent sensitivity, high specificity, and time‐saving is needed. Here, we reported a method bacterial using gold nanoparticles‐mediated fluorescent “chemical nose” sensors (GFCEs). The technique consists nanoparticles‐coated magnetic particle benzaldehyde, octyl aldehyde, pyrimidine‐4‐formaldehyde modified, respectively. And these positively...
Despite recent advances in signal reporter-based assays for bacteria detection and profiling, the low-cost, ultrasensitive, accurate, fast diagnosis remains a challenge better patient care. Herein, we present novel identification method based on α-hemolysin-labeled sandwich assay (HLSA). A pore-forming protein, α-hemolysin, is used as an electrical reporter. The takes advantage of specific binding target nucleic acid with two hybridization probes: capture probe decorated magnetic...
Abstract The MAPK pathway, via RAS-RAF-MEK-ERK, is one of the most important pathways for relaying signals from cell surface receptors survival, proliferation, and differentiation. Many mutations were identified in this pathway intensely studied, resulting a number therapeutics various cancers (for example, EGFR mutant inhibitors, BRAF V600 inhibitors MEK inhibitors). A common mechanism resistance to these has emerged be reactivation ERK1/2, terminal kinase pathway. Inhibition ERK1/2...
Pathogenic identification requires nucleic acid diagnosis with simple equipment and fast manipulation. Our work established an all-in-one strategy assay excellent sensitivity high specificity, Transcription-Amplified Cas14a1-Activated Signal Biosensor (TACAS), for the fluorescence-based bacterial RNA detection. The DNA as a promoter probe reporter directly ligated via SplintR ligase once specifically hybridized to single-stranded target sequence, ligation product transcribed into Cas14a1...