A5016742496- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- DNA and Nucleic Acid Chemistry
- Immune cells in cancer
- Advancements in Transdermal Drug Delivery
- Surfactants and Colloidal Systems
- Molecular Sensors and Ion Detection
- DNA and Biological Computing
- Advanced Drug Delivery Systems
- Drug Transport and Resistance Mechanisms
- Immunotherapy and Immune Responses
- Lipid Membrane Structure and Behavior
- Adenosine and Purinergic Signaling
- Extracellular vesicles in disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Immunotherapy and Biomarkers
- Cancer-related gene regulation
- Cancer Cells and Metastasis
- Cell Adhesion Molecules Research
- SARS-CoV-2 detection and testing
- Vagus Nerve Stimulation Research
- Sulfur Compounds in Biology
- Protein Degradation and Inhibitors
Tsinghua University
2020-2025
Beijing Academy of Science and Technology
2025
Shantou University
2022-2024
Shantou University Medical College
2022-2024
China Three Gorges University
2019-2024
Yichang Central People's Hospital
2024
Second Affiliated Hospital of Shantou University Medical College
2024
Huazhong Agricultural University
2023-2024
Jiamusi University
2016-2023
Civil Aviation Administration of China
2021-2023
Proteolysis targeting chimera (PROTAC) is an emerging protein degradation strategy, which shows excellent advantages in those so-called "undruggable" proteins. However, the potential systemic toxicity of PROTACs caused by undesired off-tissue may limit application clinical practice. Here we reported a radiotherapy-triggered PROTAC prodrug (RT-PROTAC) activation strategy to precisely and spatiotemporally control through X-ray radiation. We demonstrated this concept incorporating inducible...
Glioma is a fatal disease with limited treatment options and very short survival. Although chemotherapy one of the most important strategies in glioma treatment, it remains extremely clinically challenging largely due to blood-brain barrier (BBB) tumor (BBTB). Thus, development nanoparticles both BBB BBTB penetrability, as well glioma-targeting feature, for therapy glioma. New findings nanomedicine are promoting novel biomaterials. Herein, we designed red blood cell membrane-coated solid...
Abstract Stroke is a lethal cerebral disease with severe sequelae and high mortality. Microglia, the main immune cell in cerebrum, possess therapeutic potential for strokes as its specific anti‐inflammatory phenotype can reduce inflammation promote neuron regeneration. However, on‐demand polarization of microglia at stroke site uncontrollable application. Here, we develop platelet hybrid platform which specifically polarize to by ultrasound irradiation targeted cerebrum repair after stroke....
Glioblastoma (GBM) is the most malignant brain tumor with unmet therapeutic demand. The blood-brain-barrier (BBB) and heterogeneity limit treatment effectiveness of various interventions. Here, an ultrasound augmented chemo/immuno therapy for GBM using a neutrophil-delivered nanosensitizer, developed. sensitizer composed ZnGa2 O4 :Cr3+ (ZGO) core persistent luminescence imaging hollow sono-sensitive TiO2 shell to generate reactive oxygen species (ROS) controlled drug release. Immune...
Amplifying "eat me signal" during tumor immunogenic cell death (ICD) cascade is crucial for immunotherapy. Inspired by the indispensable role of adenosine triphosphate (ATP, a necessary ICD), versatile ICD amplifier was developed chemotherapy-sensitized Doxorubicin (DOX), ATP and ferrous ions (Fe2+) were co-assembled into nanosized (ADO-Fe) through π‒π stacking coordination effect. Meanwhile, phenylboric acid-polyethylene glycol-phenylboric acid (PBA-PEG-PBA) modified on surface ADO-Fe...
Ionic liquids (ILs) have been proven to be an effective technology for enhancing drug transdermal absorption. However, due the unique structural components of ILs, design efficient ILs and elucidation action mechanisms remain explored. In this review, basic principles ideal delivery system (TDDS) are discussed considering melting point, skin permeability, toxicity, which depend on molar ratios, types, functional groups ions inter-ionic interactions. Secondly, contributions development TDDS...
Introduction: Multidrug resistance (MDR) of breast cancer is the major challenge to successful chemotherapy while mitochondria-targeting therapy was a promising strategy overcome MDR. Materials and methods: In this study, HER-2 peptide-PEG 2000 -Schiff base-cholesterol (HPSC) derivate synthesized successfully incorporated it on surface doxorubicin (DOX)-loaded dequalinium (DQA) chloride vesicle (HPS-DQAsomes) treat drug-resistant cancer. Evaluations were performed using human cell...
Thrombin plays a critical role in hemostasis and hemolysis. It is of high importance to develop system toward thrombin detection with sensitivity selectivity for both research clinical diagnosis applications. In this paper, we developed assay by taking advantage the novel signal amplified strategy based on chiral supramolecular assembly physiological K+ background. This could detect as low concentration about 2 pM provided highly specific among several common interferences. Furthermore, can...
The therapeutic efficacy of chemotherapy is dramatically hindered by multidrug resistance (MDR), which induced the overexpression P-glycoprotein (P-gp). codelivery an antitumor drug and siRNA effective strategy recently applied in overcoming P-gp-related MDR. In this study, a multifunctional delivery system with both pH-sensitive feature active targetability was designed, MDR1-siRNA DOX were successfully loaded. resulting carrier EphA10 antibody-conjugated doxorubicin (DOX), coloading...
Therapeutic outcome for the treatment of glioma was often limited due to non-targeted nature drugs and physiological barriers, including blood-brain barrier (BBB) tumor (BBTB). An ideal glioma-targeted delivery system must be sufficiently potent cross BBB BBTB then target cells with adequate optimized physiochemical properties biocompatibility. However, it is an enormous challenge researchers engineer above-mentioned features into a single nanocarrier particle. New frontiers in nanomedicine...
Therapeutic outcome for the treatment of glioma was often limited due to non-targeted nature and low permeability drugs across blood-brain barrier (BBB). An ideal glioma-targeted delivery system need traverse BBB then target cells with adequate optimized physiochemical properties biocompatibility. However, it is an enormous challenge researchers engineer above-mentioned features into a single nanocarrier particle. New frontiers in nanomedicine are advancing research new biomaterials. In this...
The existing of avidity cancer stem cells (CSCs) made it an optical strategy to kill and CSCs at the same time. Here, we constructed a specific nanocarrier naming T-S-NLC using CD133+ targeting peptide TISWPPR (TR) as moiety attached distal end PEG on salinomycin (Sal) loaded nanostructured lipid carriers (NLC), its pharmaceutical characteristics proved 128.73 ± 2.09 nm, anionic spheroid with sustained release profile. It's in vitro effect indicated that exhibited superior internalization...
Colorectal cancer (CRC) is the second leading cause of death globally.Integrin α1 (ITGA1) belongs to integrin family and involves in regulating cell adhesion, invasion, proliferation tumorigenicity, its expression up-regulated various cancers, including CRC.However, molecular understanding clinical relevance ITGA1 development progression CRC remain unclear.In present study, we detected 50 tissues adjacent non-cancerous tissues, sera from 100 patients healthy subjects, four lines using...
Inflammatory bowel disease (IBD) is a chronic and recurrent intestinal inflammatory with high risks for colorectal cancer extremely affect people's health. Secoisolariciresinol diglucoside (SDG), major component of lignans, exerts anti-inflammatory effects against digestive system diseases through multi-target mechanism. However, the effect SDG on IBD not clear. In present study, we aimed to investigate elucidate underlying The Dextran Sulfate Sodium Salt (DSS)-induced colitis model...
Diabetic chronic wounds remain a major clinical challenge with long-term inflammatory responses and extreme oxidative damage. Hence, pH-responsive injectable multifunctional hydrogel [Gel/CUR-FCHO/Mg (GCM) micromotors] via Schiff base reaction between gelatin benzaldehyde-grafted Pluronic F127 drug-loaded micelles (FCHO) was fabricated for the first time. Dynamic linkage endowed GCM ability to be self-healing, injectable, on-demand drug delivery at wound site. Curcumin (CUR), hydrophobic...
Background: The objective of this work was to study the preparation and characteristics zedoary turmeric oil (ZTO), a traditional Chinese oily medicine, loaded with nanostructured lipid carriers (NLCs). Method: Aqueous dispersions NLC were successfully prepared by melt-emulsification technique using Crodamol SS as solid lipid, Miglyol 812N liquid oil, soybean phosphatidylcholine (SbPC) emulsifier. Properties such particle size its distribution, transmission electron microscope (TEM), drug...
A novel pH-sensitive conjugate glycyrrhetinic acid–polyethylene glycol–Schiff bond–cholesterol (GPSC) has been synthesized successfully and used to construct doxorubicin-loaded liposomes with both features active targeting ability.
The controlled release of anticancer drugs at the tumor site is a central challenge in treating cancer. To achieve this goal, our strategy was based on tumor-specific targeting and ultrasound-triggered an agent from liposomal nanocarriers. enhance drug release, we incorporated lipophilic sonosensitizer, chlorin e6 (Ce6) ester, into lipid bilayer liposomes. Additionally, asparagine-glycine-arginine (NGR) that binds to CD13, which overexpressed cells, introduced these Under navigation effects...
It is generally known that, for nanoparticles in cancer therapy, sufficient tumor penetration needs a minor particle size, while long vivo circulation time larger size. hard to balance them because they are standing on either side of seesaw. To address these two different requirements, dual-responsive size-shrinking nanocluster can self-adaptively respond complicated microenvironment and transform its particulate property overcome sequential barriers reach preferable antitumor activity. The...