A5012853482- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Memory and Neural Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Neural dynamics and brain function
- Circadian rhythm and melatonin
- Receptor Mechanisms and Signaling
- Exercise and Physiological Responses
- Evolutionary Psychology and Human Behavior
- Neural and Behavioral Psychology Studies
- Adipose Tissue and Metabolism
- Functional Brain Connectivity Studies
- Animal Behavior and Welfare Studies
- Neuroscience and Music Perception
- Sleep and Wakefulness Research
- Heart Rate Variability and Autonomic Control
- Cannabis and Cannabinoid Research
- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Treatment of Major Depression
- Molecular Communication and Nanonetworks
- Superconducting and THz Device Technology
- Safety Warnings and Signage
Boston College
2015-2025
University of Colorado Boulder
2007-2016
Center for Neurosciences
2013
University of New Hampshire
2005-2009
University of New Hampshire at Manchester
2005
Susquehanna University
2002-2003
Safety signals are learned cues that predict stress-free periods whereas behavioral control is the ability to modify a stressor by actions. Both serve attenuate effects of stressors such as uncontrollable shocks. Internal and external produced controlling behavior followed stressor-free interval, so it possible safety learning fundamental effect control. If this case then should recruit same neural machinery. Interestingly, prevented outcome exposure also blocked (reduced social exploration)...
Recent interest in the antidepressant and anti-stress effects of subanesthetic doses ketamine, an NMDA receptor antagonist, has identified mechanisms whereby ketamine reverses effect stress, but little is known regarding prophylactic might have on future stressors. Here we investigate against neurochemical behavioral changes that follow inescapable, uncontrollable tail shocks (ISs) Sprague Dawley rats. IS induces increased anxiety, which dependent activation serotonergic (5-HT) dorsal raphe...
Social interactions are shaped by features of the interactants, including age, emotion, sex, and familiarity. Age-specific responses to social affect evident when an adult male rat is presented with a pair unfamiliar conspecifics, one which stressed via two foot shocks other naive treatment. Adult test rats prefer interact juvenile (postnatal day 30, PN30) conspecifics but avoid (PN50) conspecifics. This pattern depends upon insular cortex (IC), anatomically connected nucleus accumbens core...
Abstract Impairments in identifying and responding to the emotions of others manifest a variety psychopathologies. Therefore, elaborating neurobiological mechanisms that underpin social responses emotions, or affective behavior, is translationally important goal. The insular cortex consistently implicated stress-related anxiety disorders, which are associated with diminished ability make use inferences about guide behavior. We investigated how corticotropin-releasing factor (CRF),...
The presence of behavioral control over a stressor can blunt many the effects stressor. We have recently reported that uncontrollable stress (inescapable electric tailshock, IS) reduces later social exploration juvenile whereas controllable (escapable shock, ES) does not. Activation ventral medial prefrontal cortex (vmPFC) is crucial to blunting IS on escape behavior (learned helplessness). goal current study was test role vmPFC in modulating controllability anxiety test. Thus, adult male...
Behavioral control over a stressful event reduces the negative consequences of not only that event, but also future events. Plasticity in prelimbic (PL) medial prefrontal cortex is critical to this process, nature changes induced unknown. We used patch-clamp recording measure intrinsic excitability PL pyramidal neurons acute slices from rats exposed either escapable stress (ES), for which had behavioral tail-shock termination, or inescapable (IS) without control. Shortly after exposure (2 h)...
Familiarity between conspecifics may influence how social affective cues shape behaviors. In a preference test, experimental rats, when given the choice to explore an unfamiliar stressed or naive adult, will avoid interaction with conspecific. To determine if familiarity would interactions conspecifics, male and female test rats underwent 2 tests in isosexual triads where rat was presented naïve target conspecific who were either familiar (cagemate) unfamiliar. Male avoided conspecifics....
Abstract Controllable/escapable tailshocks ( ES s) do not produce the behavioral and neurochemical outcomes produced by equal yoked uncontrollable/inescapable IS s). The prelimbic cortex is known to play a key role in mediating protective effects of control. concepts act/outcome learning control seem similar, mediated circuit involving posterior dorsomedial striatum DMS ). Thus, we tested involvement effect , rats. First, examined Fos immunoreactivity both dorsolateral DLS ) after . We then...
Distinguishing safety from danger is necessary for survival, but aberrant in individuals with post-traumatic stress disorder (PTSD). While PTSD more prevalent women than men, research on sex differences learning limited. Here, female rats demonstrated greater fear discrimination males a CS+/CS- paradigm. To determine if this difference transferred to inhibition, were tested conditioned inhibition summation test the CS+ and CS- presented compound; no emerged. The results suggest neural...
Behaviorally controllable stressors confer protection from the neurochemical and behavioral consequences of future uncontrollable stressors, a phenomenon termed "behavioral immunization". Recent data implicate protein synthesis within ventromedial prefrontal cortex (mPFC) as critical to immunization. Adult, male Sprague-Dawley rats were exposed series tailshocks 1 week later tailshocks, followed 24 h by social exploration shuttlebox escape tests. To test involvement N-methyl-D-aspartate...