A5024716304- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Memory and Neural Mechanisms
- Evolutionary Psychology and Human Behavior
- Animal Behavior and Welfare Studies
- Neuroscience and Neuropharmacology Research
- Olfactory and Sensory Function Studies
- Neurotransmitter Receptor Influence on Behavior
- Zebrafish Biomedical Research Applications
Boston College
2018-2023
Social interactions are shaped by features of the interactants, including age, emotion, sex, and familiarity. Age-specific responses to social affect evident when an adult male rat is presented with a pair unfamiliar conspecifics, one which stressed via two foot shocks other naive treatment. Adult test rats prefer interact juvenile (postnatal day 30, PN30) conspecifics but avoid (PN50) conspecifics. This pattern depends upon insular cortex (IC), anatomically connected nucleus accumbens core...
Abstract Impairments in identifying and responding to the emotions of others manifest a variety psychopathologies. Therefore, elaborating neurobiological mechanisms that underpin social responses emotions, or affective behavior, is translationally important goal. The insular cortex consistently implicated stress-related anxiety disorders, which are associated with diminished ability make use inferences about guide behavior. We investigated how corticotropin-releasing factor (CRF),...
Familiarity between conspecifics may influence how social affective cues shape behaviors. In a preference test, experimental rats, when given the choice to explore an unfamiliar stressed or naive adult, will avoid interaction with conspecific. To determine if familiarity would interactions conspecifics, male and female test rats underwent 2 tests in isosexual triads where rat was presented naïve target conspecific who were either familiar (cagemate) unfamiliar. Male avoided conspecifics....
The ability to detect, appraise, and respond another’s emotional state is essential social affective behavior. This mediated by a network of brain regions responsible for integrating external cues with internal states orchestrate situationally appropriate behavioral responses. basolateral amygdala (BLA) the insular cortex are reciprocally connected involved in cognition prior work male rats revealed their contributions We investigated functional role these female preference (SAP) test which...
Abstract Impairments in social cognition manifest a variety of psychiatric disorders, making the neurobiological mechanisms underlying decision particular translational importance. The insular cortex is consistently implicated stress-related and anxiety which are associated with diminished ability to make use inferences about emotions others guide behavior. We investigated how corticotropin releasing factor (CRF), neuromodulator evoked by both self stressors, influenced insula. In acute...
Abstract The description and quantification of social behavior in laboratory rodents is central to basic translational research. Conventional ethological approaches are fraught with challenges including bias, significant human effort temporal accuracy. Here we show proof principle that machine learning can be applied tests decision making. Rats underwent novelty preference which were scored both by hand again a convolutional neural network generated the DeepLabCut computer vision package...
The ability to detect, appraise, and respond another's emotional state is essential social affective behavior. This mediated by a network of brain regions responsible for integrating external cues with internal states orchestrate situationally appropriate behavioral responses. basolateral amygdala (BLA) the insular cortex are reciprocally connected involved in cognition prior work male rats revealed their contributions We investigated functional role these female preference (SAP) test which...
Social interactions are shaped by features of the interactants including age, emotion, sex and familiarity. Age-specific responses to social affect evident when an adult male rat is presented with a pair unfamiliar conspecifics, one which stressed via 2 footshocks other naïve treatment. Adult test rats prefer interact juvenile (PN30) but avoid (PN50) conspecifics. This pattern depends upon insular cortex (IC) anatomically connected nucleus accumbens core (NAc). The goal this work was...
Abstract Familiarity between conspecifics may influence how social affective cues shape behaviors. In a preference test, experimental rats, when given the choice to explore an unfamiliar stressed or naive adult, will avoid interaction with conspecific. To determine if familiarity would interactions conspecifics, male and female test rats underwent 2 tests in isosexual triads where rat was presented naïve target conspecific who were either familiar (cagemate) unfamiliar. Male avoided...