A5100356121- Electrospun Nanofibers in Biomedical Applications
- Hydrogels: synthesis, properties, applications
- Tissue Engineering and Regenerative Medicine
- Polymer Surface Interaction Studies
- Spine and Intervertebral Disc Pathology
- Hemostasis and retained surgical items
- 3D Printing in Biomedical Research
- Advanced Sensor and Energy Harvesting Materials
- Collagen: Extraction and Characterization
- Mesenchymal stem cell research
- Spinal Hematomas and Complications
- Blood properties and coagulation
- Liquid Crystal Research Advancements
- Extracellular vesicles in disease
- Cardiac Arrest and Resuscitation
- Supramolecular Self-Assembly in Materials
- Bone Tissue Engineering Materials
- Anesthesia and Neurotoxicity Research
- Silk-based biomaterials and applications
- Pregnancy-related medical research
- Cardiac Ischemia and Reperfusion
- Anesthesia and Pain Management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Hemophilia Treatment and Research
- Platelet Disorders and Treatments
Tianjin University
2019-2025
Tianjin Hospital
2024-2025
Collaborative Innovation Center of Chemical Science and Engineering Tianjin
2022
Over the past decade, tissue-engineering strategies, mainly involving injectable hydrogels and epicardial biomaterial patches, have been pursued to treat myocardial infarction. However, only limited therapeutic efficacy is achieved with a single means. Here, combined therapy approach proposed, that is, coadministration of conductive hydrogel patch infarcted myocardium. The self-adhesive fabricated based on Fe3+-induced ionic coordination between dopamine-gelatin (GelDA) conjugates...
Abstract 3D printing of high‐strength and antiswelling hydrogel‐based load‐bearing soft tissue scaffolds with similar geometric shape to natural tissues remains a great challenge owing insurmountable trade‐off between strength printability. Herein, capitalizing on the concentration‐dependent H‐bonding‐strengthened mechanism supramolecular poly( N ‐acryloyl glycinamide) (PNAGA) hydrogel, self‐thickening self‐strengthening strategy, that is, loading concentrated NAGA monomer into...
Natural polymer (NP) hydrogels are an irreplaceable class of biomaterials owing to their identified biosafety; however, the intrinsic poor mechanical strengths severely limit applications as structural tissue engineering scaffolds. Inspired by stiffening albumen gel tea eggs, a traditional Chinese snack, high-strength NP constructed simply soaking in aqueous solution polyphenols (TP), active ingredient extracted from tea. The TP-treated representative exhibit considerably enhanced...
Hydrogel patch-based stem cell transplantation and microenvironment-regulating drug delivery strategy is promising for the treatment of myocardial infarction (MI). However, low retention cells drugs limits their therapeutic efficacies. Here, we propose a prefixed sponge carpet strategy, that is, aldehyde-dextran (ODS) loading anti-oxidative/autophagy-regulating molecular capsules 2-hydroxy-β-cyclodextrin@resveratrol (HP-β-CD@Res) first bonded to rat's heart via capillary removal interfacial...
It has always been a huge challenge to construct high-strength hydrogels that are composed entirely of natural polymers. In this study, inspired by the structural characteristics extracellular matrix (ECM), gelatin and hydrazide alginate were employed mimic composition collagen glycosaminoglycans (GAGs) in ECM, respectively, develop polymer (NP) crosslinked physical covalent interactions (Gelatin-HAlg-DN). First, HAlg can form physically (Gelatin-HAlg) due electrostatic hydrogen bond...
Abstract As an age‐related disease, intervertebral disc degeneration is closely related to inflammation and aging. Inflammatory cytokines cellular senescence collectively contribute the degradation of disc. Blocking this synergy reduces extracellular matrix damage caused by In study, drug‐loaded nanofibers with sequential targeting functions are constructed through intelligent response, hydrophilicity, in situ self‐assembly empowerment flurbiprofen. The peptide precursor responds cleavage...
Development of a biostable and biosafe vitreous substitute is highly desirable, but remains grand challenge. Herein, we propose novel strategy for constructing readily administered based on thiol-acrylate clickable polyzwitterion macromonomer. A biocompatible multivinyl polycarboxybetaine (PCB-OAA) macromonomer designed synthesized, mixed with dithiothreitol (DTT) via Michael addition reaction to form hydrogel in cavity. This resultant PCB-OAA exhibits controllable gelation time, super...
A robust sponge fabricated by bubble expanding in thermo-initiation polymerization and lyophilization demonstrates H-bonding strengthened compressive strengths, tunable liquid uptake capability excellent hemostatic activity.
Thickening a concentrated solution of multiple-H-bonding monomer (MHM) and zwitterion (ZM) with soft poly(MHM-<italic>co</italic>-ZM) gel enables direct printing the MHM, post-polymerization generates stiff lubricative hydrogel meniscus.
Indwelling needles are widely used in the clinic for their advantages of reducing pain and discomfort caused by repeated venipuncture. Achieving anticoagulation hemostasis with one single indwelling needle is highly desired from perspective implantation patency prevention needle-withdrawal-induced uncontrolled bleeding. Herein, we develop a sophisticated an anticoagulant/hemostatic dual function anchoring anticoagulant heparin coating hemostatic hydrogel on inner surface outer needle,...