Xindi Chen

ORCID: 0000-0003-2312-8755
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About
Contact & Profiles
Research Areas
  • Acute Ischemic Stroke Management
  • Cerebrovascular and Carotid Artery Diseases
  • Pediatric Hepatobiliary Diseases and Treatments
  • Intracranial Aneurysms: Treatment and Complications
  • CRISPR and Genetic Engineering
  • Cardiovascular Health and Disease Prevention
  • Drug Transport and Resistance Mechanisms

Mayo Clinic in Florida
2024-2025

Jacksonville College
2024

Cincinnati Children's Hospital Medical Center
2022

The truncating mutations in tight junction protein 2 (TJP2) cause progressive cholestasis, liver failure, and hepatocyte carcinogenesis. Due to the lack of effective model systems, there are no targeted medications for pathology with TJP2 deficiency. We leveraged technologies patient-specific induced pluripotent stem cells (iPSC) CRISPR genome-editing, we aim establish a disease which recapitulates phenotypes patients

10.1016/j.jhepr.2022.100446 article EN cc-by JHEP Reports 2022-02-01
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