A5049777000- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Autoimmune Neurological Disorders and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Infectious Encephalopathies and Encephalitis
- Neurological diseases and metabolism
- Prion Diseases and Protein Misfolding
- Tryptophan and brain disorders
- Pluripotent Stem Cells Research
- Polyomavirus and related diseases
- RNA regulation and disease
- Spinal Cord Injury Research
- Genetic Neurodegenerative Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Dysphagia Assessment and Management
- Hereditary Neurological Disorders
- Long-Term Effects of COVID-19
- Spondyloarthritis Studies and Treatments
- Infant Health and Development
- Systemic Sclerosis and Related Diseases
- Ophthalmology and Eye Disorders
- Parkinson's Disease and Spinal Disorders
Moscow Research and Clinical Center for Neuropsychiatry
2016-2024
Institute of Higher Nervous Activity and Neurophysiology
2007-2024
Moscow City Clinical Hospital after V.M. Buyanov
2015-2023
City Clinical Hospital
2017-2023
The University of Queensland
2021
Research Center of Neurology
2009-2014
Russian Academy of Sciences
2007-2014
Academy of Medical Sciences
2008-2014
Yoga originated in the territory of modern India more than 3,000 years ago uses techniques for working with musculoskeletal system, cardiorespiratory and attention. Currently, effectiveness safety yoga patients various neurological disorders, including multiple sclerosis (MS), is interest to many scientists clinicians.The main aim this study examine effect on symptoms quality life MS vs physical therapy (exercise therapy) no exercise.The were randomly assigned three groups (yoga, (PT), or...
To evaluate the efficacy and safety of tolpersione injection oral formulations combined with NSAID over monotherapy in acute non-specific low back pain.In this randomized double blind study 239 patients were included per protocol analysis. The first 5 days treatment, received or placebo which was followed by os administration tolpersione/placebo tablet up to 14 days. diclofenac used both groups through study. Functionality assessed Roland Morris Disability Questionnaire (RMDQ) at day primary...
Respiratory failure, malnutrition, aspiration pneumonia, and dehydration are the precursors to mortality in ALS. Loss of natural communication is considered one worst aspects This first study test feasibility a music therapy protocol for bulbar respiratory rehabilitation ALS employs mixed-methods case series design with repeated measures. Newly diagnosed patients meeting inclusion criteria were invited participate, until desired sample size (n = 8) was achieved. The delivered participants...
A few groups have suggested that activated cytokines and nitrosative stress are closely involved in the pathogenesis of different demyelinating disorders induced by neuroinflammatory destruction neurons. The purpose this study was to elucidate associations S-nitrosothiols (RSNO) with severity neurodegeneration during relapse central nervous system.We measured levels interleukin-6 (IL-6), erythropoietin, RSNO, phosphorylated neurofilament heavy chain (pNfh) cerebrospinal fluid (CSF) samples...
Background: Pediatric investigation plans (PIPs) describe how adult drugs can be studied in children. In 2015, PIPs for Amyotrophic Lateral Sclerosis (ALS) became mandatory European marketing-authorization of treatments, unless a waiver is granted by the Medicines Agency (EMA).Objective: To assess feasibility clinical studies on effect therapy children (<18 years) with ALS Europe.Methods: The EMA database was searched submitted ALS. A questionnaire sent to 58 centers collect prevalence...
Objectives: To estimate the incidence of amyotrophic lateral sclerosis (ALS) in Moscow by investigating multiple sources cases. Incidence rates from previous Russian studies ranged 0.3 to 0.7 per 100,000/year. Methods: A retrospective study ALS was performed South district (population, 1,760,000, 2015). Several data were investigated. The medical records calendar year 2015 examined an expert who accepted only patients with definite or probable according revised El Escorial criteria. Crude...
To translate into Russian and adapt the Edinburgh Cognitive Behavioral ALS Screen (ECAS) for patients with amyotrophic lateral sclerosis (ALS).Medical care requires participation of a multidisciplinary team. More than one third suffer from cognitive behavioral disturbances, it influences decisions team, family. The scale measuring these disturbances should be rapid understandable evaluation take account specificity impairments in ALS.ECAS met criteria allows screening examination at...
Cognitive disorders (CD) are observed in more than half of patients with amyotrophic lateral sclerosis (ALS), but rarely reach the degree dementia. Currently, a classification ALS has been proposed depending on presence cognitive and/or behavioral disorders. CD can be represented by speech fluency disorders, various aphasic regulatory functions, social and verbal memory. The most diagnostically sensitive special scales, such as Edinburgh Behavioral Impairment Screening Scale for ALS. have...
Introduction: Transthyretin (ATTR) amyloidosis is a severe rare disease with wide range of characters without specific symptoms including the damage to peripheral nervous system and cardiac involvement. Case report: A 60-year-old female patient represented weakness paresthesia in distal parts lower limbs, impeding walking for 2 years. Initially, were considered as manifestation degenerative stenosis lumbar spine, decompressive laminectomy was performed but after surgical treatment persisted....
Levamisole is an immunomodulatory drug which can trigger development of levamisole-induced multifocal inflammatory leukoencephalopathy (LIMIL) in patients treated for helminthic invasion, aphthous stomatitis, cancer, or cocaine users. LIMIL clinical case patient 45 years old after single dose levamisole (taken without any medical prescription) was described. We presented history and picture, MRI laboratory data treatment results during 1-year observation. According to similarity with acute...
Neuropsychiatric presentations are observed in a substantial number of patients with amyotrophic lateral sclerosis (ALS). Severe behavioral disorders develop ALS combined frontotemporal dementia, which considered to be disease continuum. Psychiatric predominantly motor symptoms less prominent and mostly presented apathy. by their origin could psychogenic, reflecting the patients' reactions on severe disease, organic, developing as result degeneration central neurons disconnection between...
The completion of the genome has paved way for genome-wide association studies (GWAS), which explained certain proportions heritability. GWAS are not optimally suited to detect non-linear effects in disease risk, possibly hidden non-additive interactions (epistasis). Alternative methods epistasis detection using, e.g. deep neural networks (DNNs) currently under active development. However, DNNs constrained by finite computational resources, can be rapidly depleted due increasing complexity...