A5005638521- Cytomegalovirus and herpesvirus research
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Herpesvirus Infections and Treatments
- HIV Research and Treatment
- Hydrogen's biological and therapeutic effects
- Chemical Reactions and Isotopes
- Toxin Mechanisms and Immunotoxins
- Synthesis and Biological Evaluation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Research on Leishmaniasis Studies
- Diet and metabolism studies
- interferon and immune responses
- Toxoplasma gondii Research Studies
Institut National de la Recherche Scientifique
2020-2023
Medical University of Vienna
2019-2020
Leishmania donovani is a causative agent of visceral leishmaniasis, potentially lethal disease characterized by strong B cell activation and the subsequent excessive production nonprotective antibodies, which are known to worsen disease. How activates cells still unknown, particularly because this parasite mostly resides inside macrophages would not have access during infection.
HIV-1 infection is characterized by a strong inflammatory environment, tissue disruption, and progressive decline in CD4+ T cell count. Despite treatment with antiretroviral therapy (ART), the majority of persons living HIV (PLWH) maintain residual levels inflammation, low degree immune activation, higher sensitivity to death their memory T-cell compartment. To date, mechanisms responsible for this high remain elusive. We have identified transcription factor IRF-5 be involved impairing...
Human cytomegalovirus (HCMV) envelope glycoprotein complexes, gH/gL/gO trimer and gH/gL/UL128-131 pentamer, are important for cell-free HCMV entry. While soluble NRP2-Fc (sNRP2-Fc) interferes with epithelial/endothelial cell entry through UL128, platelet-derived growth factor receptor α-Fc (sPDGFRα-Fc) interacts gO, thereby inhibiting infection of all types. Since gO is the most variable subunit, we investigated influence polymorphism on inhibitory capacities sPDGFRα-Fc sNRP2-Fc....
Abstract Human cytomegalovirus (HCMV) envelope glycoprotein complexes, gH/gL/gO-trimer and gH/gL/UL128L-pentamer, are important for cell-free HCMV entry. While soluble Nrp2-Fc (sNrp2-Fc) interferes with epithelial/endothelial cell entry through UL128, PDGFRα-Fc (sPDGFRα-Fc) interacts gO thereby inhibiting infection of all types. Since is the most variable subunit we investigated influence polymorphism on inhibitory capacities sPDGFRα-Fc sNRP2-Fc. Accordingly, genotype 1c (GT1c) sequence was...