A5066821940- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders Research
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Psoriasis: Treatment and Pathogenesis
- Systemic Lupus Erythematosus Research
- Biosimilars and Bioanalytical Methods
- Monoclonal and Polyclonal Antibodies Research
- Family Support in Illness
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Bone and Joint Diseases
- Adolescent and Pediatric Healthcare
- Inflammatory Bowel Disease
- Acute Lymphoblastic Leukemia research
- Attachment and Relationship Dynamics
- Health Systems, Economic Evaluations, Quality of Life
- Systemic Sclerosis and Related Diseases
- Acute Myocardial Infarction Research
- HER2/EGFR in Cancer Research
- Mental Health and Patient Involvement
- Chronic Disease Management Strategies
- Patient-Provider Communication in Healthcare
- Inflammatory Myopathies and Dermatomyositis
- Marriage and Sexual Relationships
Janssen (Belgium)
2015-2023
Parkside Hospital
2020
Janssen (Switzerland)
2020
ORCID
2020
McGill University
2020
JSS Medical Research (India)
2020
Waters (United Kingdom)
2020
Memorial University of Newfoundland
2020
Université Laval
2020
Keystone College
2020
To evaluate the efficacy and safety of adding intramuscular (IM) gold to treatment regimen patients with rheumatoid arthritis (RA) who have a suboptimal response methotrexate (MTX).A randomized, double-blind, double-observer, placebo-controlled multicenter trial 48 weeks was conducted. Sixty-five RA had >/=12 MTX therapy were randomly assigned receive weekly IM or placebo in addition MTX. Gold administered according standard protocol developed for study. The primary outcome measure...
To determine whether perceptions of clinical manifestations (fatigue, pain, and physical limitation) rheumatoid arthritis (RA) differ between spouses their partners with RA, to the differences are associated perception beneficial problematic spousal social support.English-speaking adults RA ≥ 6 months' duration (n = 222 couples) completed standardized questionnaires for fatigue, limitation, support, support. Spouses based on partner RA. Agreement scores limitation were calculated by...
Abstract Objective To examine the role of spouse mood in disability and disease course persons with rheumatoid arthritis (PWRA). Methods A total 133 married PWRA completed questionnaires, including Rheumatoid Arthritis Disease Activity Index Disabilities Arm, Shoulder, Hand, assessing activity disability, respectively, at 2 time points 1 year apart. In addition, both their spouses Center for Epidemiologic Studies Depression Scale, a standardized community measure depression points. Results...
To describe the profile of rheumatoid arthritis (RA) patients treated with infliximab in Canadian routine care and to assess real-world effectiveness safety infliximab.Biologics-naive RA from Biologic Treatment Registry Across Canada were stratified based on their enrollment year. Effectiveness was assessed changes clinical/laboratory parameters patient-reported outcomes achievement minimal disease activity remission. Safety incidence treatment-emergent adverse events (AEs).Among 628...
To describe the minimal disease activity (MDA) rate over time in patients with psoriatic arthritis (PsA) receiving antitumour necrosis factor agents, evaluate prognostic factors of MDA achievement and identify most common unmet criteria among achievers.Biologic Treatment Registry Across Canada (BioTRAC): ongoing, prospective registry initiating treatment for rheumatoid arthritis, ankylosing spondylitis or PsA infliximab (IFX), golimumab (GLM) ustekinumab.46 primary-care Canadian rheumatology...
To examine the effects of depressive symptoms and spouse empathic responding on patient disability marital quality over time to identify factors that contribute patients perceiving their spouses as empathically rheumatoid arthritis (RA).Patients diagnosed with RA (n = 133 couples) independently completed mailed questionnaires at baseline 1 year later. Patients measures functional impairment, quality, symptoms, perceived from spouse. Spouses reported own behavior.Perceived was found interact...
Objective To describe the rate of concomitant oral corticosteroid use at antitumour necrosis factor (TNF) initiation and disease remission, to assess its effect on incidence infection sustainability remission among patients with rheumatoid arthritis (RA) treated infliximab in Canadian routine care. Methods Biological naïve RA followed Bio logic T reatment R egistry A cross C anada (BioTRAC) were included. The time-dependent association between dose (no use, ≤5 mg/day, >5 mg/day) first...
Objectives To describe the profile of patients with ankylosing spondylitis (AS) treated infliximab in Canadian routine care and to assess effectiveness safety real world. Setting 46 primary rheumatology practices across Canada. Participants 303 biological-naïve AS or previously a biological for <6 months who were eligible treatment as per within Biologic Treatment Registry Across Canada (BioTRAC). Intervention Not applicable (non-interventional study). Primary secondary outcomes...
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Long-term clinical registries are essential tools to evaluate new therapies in a patient population that differs from those randomized trials. The objectives describe the profile of rheumatoid arthritis (RA) patients treated with anti-TNF agents Canadian routine care.
Treat to target recommendations for PsA state that the of treatment should be remission or, at very least, low disease activity. Different clinical indexes have been proposed define these states including minimal activity criteria and Disease Activity Index (DAPSA) scores, which 7 4-5 domains, respectively. Using a Canadian cohort, objectives were calculate proportion patients achieving criteria, their prognostic value overall patient impact states.BioTRAC is an ongoing, prospective registry...
Objectives The objectives of this study were to describe the demographic profile and baseline disease characteristics patients with psoriatic arthritis (PsA) treated either infliximab (IFX), subcutaneous golimumab (GLM) or ustekinumab (UST) treatment in Canadian routine care setting along assessing long-term effectiveness safety. Methods Patients PsA enrolled into Biologic Treatment Registry Across Canada registry (ClinicalTrials.gov Identifier: NCT00741793 ) from 2005 2017. visits occurred...
Abstract Objectives To (i) determine whether sustained disease activity states, as measured by Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Score (ASDAS), impact function, (ii) evaluate characteristics predicting low functional impairment in a prospective axial spondyloarthritis (axSpA) cohort. Methods Biologic Treatment Registry Across Canada (BioTRAC) was multi-center, registry that collected real-world data on axSpA patients receiving infliximab or golimumab between...
Abstract Background The objectives of this study were to describe the profile ankylosing spondylitis (AS) patients treated with either infliximab (IFX) or subcutaneous golimumab (GLM) treatment in Canadian routine care setting along assessing long-term effectiveness and safety. Methods AS who eligible for IFX GLM as per their respective product monographs enrolled into BioTRAC registry from 2005 2017. visits occurred at baseline every 6 months thereafter. Effectiveness was assessed by...
<h3>Background</h3> Long-term registries are essential to evaluate new therapies in a patient population that differs from clinical trials and usually varies over time. <h3>Objectives</h3> To describe the profile of psoriatic arthritis (PsA) patients selected for treatment with infliximab (IFX), golimumab (GLM) or ustekinumab (UST) Canadian routine care long-term real-world effectiveness safety these agents. <h3>Methods</h3> 462 PsA treated IFX, GLM UST were enrolled into Biologic Treatment...
<h3>Background</h3> Early achievement of minimal disease activity (MDA) is recommended as a valid treat-to-target approach in psoriatic arthritis (PsA). <h3>Objectives</h3> The purpose the current analysis was to evaluate predictors MDA PsA patients treated with anti-TNF agents Canadian routine clinical care. <h3>Methods</h3> BioTRAC an ongoing, prospective registry initiating treatment for rheumatoid arthritis, ankylosing spondylitis, or Infliximab (IFX) Golimumab (GLM). Eligible people...
<h3>Background</h3> In recent years, disease remission in rheumatoid arthritis (RA) has been assessed using various activity indices such as the DAS28, SDAI, CDAI, ACR/EULAR-recommended Boolean definition and Patient Activity Scale (PAS). <h3>Objectives</h3> The aim of this analysis is to describe agreement between these five classifying well assess their correlation a routine clinical care setting. <h3>Methods</h3> BioTRAC an ongoing, prospective Canadian registry rheumatology patients...
Abstract Background Long-term clinical registries are essential tools to evaluate new therapies in a patient population that differs from those randomized trials. The objectives describe the profile of rheumatoid arthritis (RA) patients treated with anti-TNF agents Canadian routine care. Methods RA eligible for treatment Infliximab (IFX), golimumab (GLM) or intravenous (GLM-IV) as per their respective product monographs were enrolled into BioTRAC registry between 2002 and 2017. Study visits...
<h3>Background</h3> Spondyloarthritis, including psoriatic arthritis (PsA), is characterized by inflammatory affecting axial and peripheral joints. It commonly associated with extra-articular peri-articular manifestations (PAMs) dactylitis enthesitis. <h3>Objectives</h3> To evaluate the point prevalence of enthesitis at time anti-TNF initiation, their impact on disease severity, evolution over in patients active PsA treated a routine clinical practice setting. <h3>Methods</h3> BioTRAC an...