A5016475620- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- BRCA gene mutations in cancer
- FOXO transcription factor regulation
- Thyroid Cancer Diagnosis and Treatment
- Chemokine receptors and signaling
- HIV Research and Treatment
- Natural product bioactivities and synthesis
- Health Literacy and Information Accessibility
- Vaccine Coverage and Hesitancy
- Protein Structure and Dynamics
- Microbial Community Ecology and Physiology
- Occupational Health and Burnout
- Occupational Health and Safety Research
- Wastewater Treatment and Nitrogen Removal
- Monoclonal and Polyclonal Antibodies Research
- Microbial bioremediation and biosurfactants
- Misinformation and Its Impacts
- Biomimetic flight and propulsion mechanisms
- Hematopoietic Stem Cell Transplantation
- Pharmacological Effects of Natural Compounds
- Enzyme Structure and Function
- Endoplasmic Reticulum Stress and Disease
University of Lausanne
2018-2023
University of Beira Interior
2023
Calouste Gulbenkian Foundation
2019-2020
Instituto Gulbenkian de Ciência
2019-2020
University of Algarve
2019
Universidade do Porto
2013-2018
Amazon (United States)
2018
Universidade Federal de Rondônia
2018
Universidad Pablo de Olavide
2018
Universidade Nova de Lisboa
2012-2016
The formation of central CD8 T cell memory in response to infection depends on the transcription factor Tcf1 (Tcf7). is expressed at high levels naive cells but downregulated most during effector differentiation. relevance downregulation for differentiation and signals controlling expression have not been elucidated. Here, we show that systemic inflammatory dendritic vaccination bacterial infections. suppressive effect was mediated by cytokine interleukin 12 (IL-12), which acted via STAT4...
FOXE1 is a transcription factor required for thyroid differentiation and function. locus polymorphisms (chromosome 9q22.33) were recently associated with increased sporadic cancer risk. In this study, we aimed to investigate the association of variants nonmedullary (NMTC), in both familial (FNMTC) cases from Portuguese population.Nine located at sequenced genomic DNA 60 FNMTC probands 80 patients NMTC. Alleles tested cancer, against 130 healthy matched controls.All significantly risk when...
In response to infection, naïve CD8+ T (TN) cells yield a large pool of short-lived terminal effector (TTE) that eliminate infected host cells. parallel, minor population stem cell-like central memory (TCM) forms, which has the capacity maintain immunity after pathogen clearance. It remained uncertain whether stem-like TCM arise by dedifferentiation from subset cytolytic TTE or priming generates capable seeding compartment and, if so, when branch off. Here, we show with properties, are...
Abstract Thymus autonomy is the capacity of thymus to maintain T lymphocyte development and export independently bone marrow contribution. Prolonging was shown be permissive cell acute lymphoblastic leukemia (T-ALL), similar human disease. In this study, performing transplantation experiments in mice, we report that can occur several experimental conditions, all are T-ALL. We show wild type thymi their function production upon into recipients with genotypes (and corresponding phenotypic...
Introduction/Objective: Pandemic of COVID-19 is a major public health problem. At the time development this study, no specific medication/vaccine for disease was approved. Therefore, preventive measures were main key to control pandemic. Health literacy (HL) ability obtain, understand and use information make free informed decisions about an individual promote community empowerment. Thus, HL important empowerment adoption measures. This article aims possible predictors COVID-19, functional...
Cell competition in the thymus is a homeostatic process that drives turnover. If impaired, thymopoiesis can be autonomously maintained for several weeks, but this causes leukemia. We aimed to understand effect of cell on thymopoiesis, identify cells involved, and determine how regulated. Using transplantation experiments, we found occurs within double-negative 2 (DN2) 3 early (DN3e) thymocytes inhibits autonomy. Furthermore, expansion DN2b regulated by negative feedback loop imposed...
The ability of HIV-1 to replicate and establish long-term reservoirs is strongly influenced by T cell activation. Through the use membrane-tethered, genetically encoded calcium (Ca2+) indicators, we were able detect for first time, our knowledge, formation Ca2+ territories determine their role in coordinating functional signaling nanostructure synaptic membrane. Consequently, report a previously unknown immune subversion mechanism involving exploitation, through its Nef accessory protein,...
Licorice extracts have been used in dermatologic formulations mainly due to the health promoting properties of Licochalcone A present considerable quantities. However, no electroanalytical methodologies developed so far aiming its analysis. In this work, licochalcone was electrochemically analyzed on a hanging mercury drop electrode (HMDE) by square wave voltammetry (SWV). It extracted from Glycyrrhiza glabra sonication with acetonitrile and quantified thereafter using standard additions...
SUMMARY Cell competition in the thymus is a homeostatic process that drives turnover. If impaired, thymopoiesis can be autonomously maintained for several weeks, but this causes leukemia. We aimed to understand impact of cell on thymopoiesis, identify cells involved and determine how regulated. Using transplantation experiments we found occurs within double negative 2 (DN2) 3 early (DN3e) thymocytes inhibits autonomy. Furthermore, expansion DN2b regulated by feedback loop imposed positive...
The study with the penitentiary agents that work in female prison system of Porto Velho aimed to analyze level job satisfaction and mental suffering these workers.It is a descriptive cross-sectional study.This was performed 34% who carry out their activities at Women's Penitentiary, Rondônia.For data collection, three structured instruments were used: Sociodemographic Questionnaire; Self-Report-Questionnaire (SRQ-20), Occupational Stress Indicator (OSI), measured using Likert...
Animals and insects have been investigated because of their locomotion form that allows simultaneous thrust lift production at low Reynolds numbers. The present study focuses on the experimental investigation a plunging NACA0012 airfoil under asymmetric conditions. Tests are conducted with number 1x10^4, considering two nondimensional velocities, kh=0.25 0.50. Each these conditions is tested different levels asymmetry, depending limitations apparatus. Flow visualization indicates movements...