A5024870045- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Genomic variations and chromosomal abnormalities
- Milk Quality and Mastitis in Dairy Cows
- Genetics and Plant Breeding
- Effects of Environmental Stressors on Livestock
- Genetic factors in colorectal cancer
- Wnt/β-catenin signaling in development and cancer
- Microbial infections and disease research
- Reproductive Physiology in Livestock
- dental development and anomalies
- Cancer Genomics and Diagnostics
- Ruminant Nutrition and Digestive Physiology
- Chromosomal and Genetic Variations
- Animal Genetics and Reproduction
- Prenatal Screening and Diagnostics
- Molecular Biology Techniques and Applications
University of Guelph
2016-2021
The economic importance of genetically improving feed efficiency has been recognized by cattle producers worldwide. It the potential to considerably reduce costs, minimize environmental impact, optimize land and resource use efficiency, improve overall industry’s profitability. Feed is a complex trait that can be described as units product output (e.g., milk yield) per unit input. main objective this review paper present an overview genetic physiological mechanisms underlying utilization in...
The Resilient Dairy Genome Project (RDGP) is an international large-scale applied research project that aims to generate genomic tools breed more resilient dairy cows. In this context, improving feed efficiency and reducing greenhouse gases from a high priority. inclusion of traits related (e.g., dry matter intake [DMI]) or methane emissions [CH
This study aimed to evaluate the impact of copy number variants (CNV) on 13 reproduction and 12 disease traits in Holstein cattle. Intensity signal files containing log R ratio B allele frequency information from 13,730 animals genotyped with a 95K SNP panel, 8,467 50K panel were used identify CNVs. Subsequently, identified CNVs validated using whole-genome sequence data 126 animals, resulting 870 high-confidence variant regions (CNVR) 12,131 animals. Out these, 54 CNVR had frequencies...
Genome-wide association studies based on SNP have been completed for multiple traits in dairy cattle; however, copy number variants (CNV) could add genomic information that has yet to be harnessed. The objectives of this study were identify CNV genotyped Holstein animals and assess their with hoof health using deregressed estimated breeding values as pseudophenotypes. A total 23,256 comprising 1,645 regions identified 5,845 animals. Fourteen harboring structural variations, including 9...
Abstract Background Copy number variants (CNVs) contribute to genetic diversity and phenotypic variation. We aimed discover CNVs in taurine cattle using a large collection of whole-genome sequences provide an interactive database the identified CNV regions (CNVRs) that includes visualizations sequence read alignments, boundaries, genome annotations. Results were each 4 sequencing datasets, which together represent >500 bulls from 17 breeds, popular multi-sample read-depth−based...
Abstract Multiple methods to detect copy number variants (CNV) relying on different types of data have been developed and CNV shown an impact phenotypes numerous traits economic importance in cattle, such as reproduction immunity. Further improvements detection are still needed regard the trade-off between high-true low-false positive variant identification rates. Instead improving single methods, can be identified silico with high confidence when multiple datasets combined. Here, were from...
Imputation of high-density genotypes to whole-genome sequences (WGS) is a cost-effective method increase the density available markers within population. Imputed have been successfully used for genomic selection and discovery variants associated with traits interest To allow use imputed analyses, accuracy imputation must be high. Accuracy influenced by multiple factors, such as size composition reference group, allele frequency included. Understanding WGSs prior generation population...
Feed efficiency has become an increasingly important research topic in recent years. As feed costs rise and the environmental impacts of agriculture more apparent, improving with which dairy cows convert to milk is important. However, intake expensive measure accurately on large populations, making inclusion this trait breeding programs difficult. Understanding how genetic parameters traits related vary throughout lactation period valuable gain understanding into nature efficiency. This...
Supernumerary teats (SNT) are any present on a cow's udder other than the regular four. In Swiss Brown cows, 19.9% carry SNT. Different stages of development SNT observed from rudimentary appendices to functional and possibly lactating teats. may promote mastitis, impeach good placement milking machine lower market price animals. No genetic analysis trait has been done in this cattle population, although have routinely recorded with conformation traits since 1995 Switzerland. This study...
Increasing international demand for high quality dairy and meat products as well greater awareness of climate change has put pressure on the livestock industry to deliver while reducing its environmental impact. Enteric methane from cattle is a major contributor greenhouse gas emissions target reduction through improving cow feed efficiency (FE) (ME). The overall goal this project produce genomic predictions FE ME that are ready breeding application in industry. Breeding improved less...
The combined effects of world population growth, rising incomes and dietary changes have resulted in an increasing international demand for dairy meat products. However, livestock can negative impacts on the environment greater awareness climate change has placed pressure industry to reduce its environmental impact. Enteric methane from cattle been recognized as one major contributor greenhouse gas emissions. In addition, resulting digestive processes ruminants represents important energy...