A5088695376- Mitochondrial Function and Pathology
- Tannin, Tannase and Anticancer Activities
- Pomegranate: compositions and health benefits
- Heme Oxygenase-1 and Carbon Monoxide
- Traumatic Brain Injury Research
- Biochemical effects in animals
- Regulation of Appetite and Obesity
- Antioxidant Activity and Oxidative Stress
- Autophagy in Disease and Therapy
- Traumatic Brain Injury and Neurovascular Disturbances
- Adipose Tissue and Metabolism
- Nuclear Receptors and Signaling
- Neurogenesis and neuroplasticity mechanisms
- Alzheimer's disease research and treatments
- PI3K/AKT/mTOR signaling in cancer
- Anesthesia and Neurotoxicity Research
- Biochemical Analysis and Sensing Techniques
- Neuroscience and Neuropharmacology Research
- Genomics, phytochemicals, and oxidative stress
- Glioma Diagnosis and Treatment
- Early Childhood Education and Development
- Family and Patient Care in Intensive Care Units
- Memory and Neural Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Cancer-related Molecular Pathways
Healthy Start
2023
Cicatelli Associates
2023
Yale University
2023
Cornell University
2023
University of California, San Francisco
2023
The University of Texas Health Science Center at Houston
2018-2022
The University of Texas at Dallas
2015-2016
Ohio University
1934
While high-fat diets are associated with rising incidence of obesity/type-2 diabetes and can induce metabolic cognitive deficits, sex-dependent comparisons rarely systematically made. Effects exclusive consumption a diet (HFD) on systemic metabolism behavioral measures hippocampal-dependent memory were compared in young male female LE rats. Littermates fed from weaning either HFD or control (CD) for 12 wk prior to testing. Sex-different effects the observed classic signs type-2 diabetes....
Abstract The survival and function of brain cells requires uninterrupted ATP synthesis. Different structures subserve distinct neurological functions, therefore have different energy production/consumption requirements. Typically, mitochondrial is assessed following their isolation from relatively large amounts starting tissue, making it difficult to ascertain production/failure in small anatomical locations. In order overcome this limitation, we developed optimized a method measure tissue...
High-fat diets promoting obesity/type-2 diabetes can impair physiology and cognitive performance, although sex-dependent comparisons of these impairments are rarely made. Transient reductions in Ca(2+)-dependent afterhyperpolarizations (AHPs) occur during memory consolidation, enhancing intrinsic excitability hippocampal CA1 pyramidal neurons. In rats fed standard diets, insulin enhance reduce amplitude duration AHPs. Effects chronic high-fat diet (HFD) on memory, circulating insulin,...
Some of the prominent features long-term memory formation include protein synthesis, gene expression, enhanced neurotransmitter release, increased excitability, and new synapses. As these processes are critically dependent on mitochondrial function, we hypothesized that respiration dynamics would play a role in formation. To address this possibility, measured oxygen consumption (OCR) hippocampal tissue punches from trained untrained animals. Our results show context fear training...
Abstract Pro‐energetic effects of functionalized, oxidized carbon nanozymes (OCNs) are reported. OCNs, derived from harsh acid oxidation single‐wall nanotubes or activated charcoal previously shown to possess multiple nanozymatic activities including mimicking superoxide dismutase and catalyzing the reduced nicotinamide adenine dinucleotide (NADH) NAD + . These actions predicted generate a glycolytic shift enhance mitochondrial energetics under impaired conditions. Impaired energy metabolism...
In the majority of cases, cognitive and behavioral impairments resulting from a mild traumatic brain injury (TBI) (also referred to as concussion) wane within days weeks. contrast, these can persist for months years after repetitive TBI (rmTBI). The cellular molecular mechanisms underlying are not well understood. present study, we examined consequences rmTBI (three weight drops each separated by 72 h) on tissue respiration, pathology, performance in mice. transcription factor nuclear...
Hippocampal place cells play an integral role in generating spatial maps. Impaired memory is a characteristic pathology of Alzheimer's disease (AD), yet it remains unclear how AD influences the properties hippocampal cells.To record electrophysiological activity CA1 neurons freely-moving 18-month-old male TgF344-AD and age-matched wild-type (WT) littermates to examine cell properties.We implanted 32-channel electrode arrays into subfield WT (n = 6/group) rats. Ten days after implantation,...
Rothmund-Thomson syndrome (RTS) is an autosomal recessive genetic disorder characterized by poikiloderma, small stature, skeletal anomalies, sparse brows/lashes, cataracts, and predisposition to cancer. Type 2 RTS patients with biallelic RECQL4 pathogenic variants have multiple anomalies a significantly increased incidence of osteosarcoma. Here, we generated patient-derived induced pluripotent stem cells (iPSCs) dissect the pathological signaling leading patient-associated iPSC-derived...
Last week, at the Sixth Annual Traumatic Brain Injury Conference in Arlington, Virginia, neurologist Samuel Gandy presented a former National Football League player's positron emission tomography (PET) scan as most dramatic evidence yet of chronic traumatic encephalopathy (CTE) living person. I've never seen anything like it, he said scan, which used PET tracer called T807 to reveal deposits sticky, helical protein tau brain. The announcement could represent milestone for imaging, promising...
(1934). Sex of Experimenter and Intelligence as Factors in Maze Learning: A Further Comparison Differences. The Pedagogical Seminary Journal Genetic Psychology: Vol. 44, No. 1, pp. 239-246.
Abstract Ellagic acid is a botanical polyphenol which has been shown to have numerous effects on cellular function. can induce apoptosis and inhibit the proliferation of various cancer cell types in vitro vivo . As such, ellagic attracted significant interest as potential chemotherapeutic compound. One mechanism by proposed affect physiology regulating metabolic pathways. Here we show dose-dependent energy production downstream induction apoptotic program HEK293, HeLa, MCF7, HepG2 cells. At...
Abstract Mild traumatic brain injury (mTBI) can initiate complex pathophysiological changes in the brain. Numerous cellular and molecular mechanisms underlying these pathologic are altered after injury, including those involved energy utilization, excitotoxicity, ionic disturbances, inflammation. It is thought that targeting multiple may be necessary to produce meaningful reductions pathology improve outcome. Previous studies have reported anti-diabetic drug metformin also affect...
To determine whether a community-informed, language-concordant postpartum video education campaign, developed with community input, improves patients' knowledge of warning signs for maternal mortality (infection, hemorrhage, hypertensive disorders, and depression) compared routine discharge procedures.A single-center, investigator-blinded, parallel-group randomized controlled trial individuals who delivered at large, urban, tertiary care hospital. Eligible participants were enrolled...