A5070565040- Mitochondrial Function and Pathology
- Angiogenesis and VEGF in Cancer
- ATP Synthase and ATPases Research
- Endoplasmic Reticulum Stress and Disease
- Zebrafish Biomedical Research Applications
- Phytochemistry and biological activity of medicinal plants
- Cellular transport and secretion
- Pineapple and bromelain studies
- TGF-β signaling in diseases
- Biomarkers in Disease Mechanisms
- Epigenetics and DNA Methylation
- Erythrocyte Function and Pathophysiology
- Hippo pathway signaling and YAP/TAZ
- Birth, Development, and Health
- Free Radicals and Antioxidants
- Pharmacological Effects of Natural Compounds
- Renal and Vascular Pathologies
- Metabolism, Diabetes, and Cancer
- Animal Nutrition and Physiology
- Nanocomposite Films for Food Packaging
- Adipose Tissue and Metabolism
- Pregnancy and preeclampsia studies
- Metabolism and Genetic Disorders
- Cancer, Hypoxia, and Metabolism
- Phytochemicals and Antioxidant Activities
University of Arizona
2021-2024
Sonora Institute of Technology
2016-2018
Abstract Defective angiogenesis underlies over 50 malignant, ischemic and inflammatory disorders yet long-term therapeutic applications inevitably fail, thus highlighting the need for greater understanding of vast crosstalk compensatory mechanisms. Based on proteomic profiling angiogenic endothelial components, here we report β IV -spectrin, a non-erythrocytic cytoskeletal protein, as critical regulator sprouting angiogenesis. Early loss endothelial-specific -spectrin promotes embryonic...
Aloin is an anthraquinone-C-glycoside present in Aloe vera. This compound extremely variable among different species and highly depends on the growing conditions of plants. The quantification aloin extraction preparations has been a frequent problem due to high instability compound. aim study develop validated analytical method for detection fresh dry samples barbadensis gel latex using performance liquid chromatography coupled diode array detector (HPLC-DAD). Phosphate buffered saline (pH...
Dynamic changes in the endoplasmic reticulum (ER) morphology are central to maintaining cellular homeostasis. Microtubules (MT) facilitate continuous remodeling of ER network into sheets and tubules by coordinating with many ER-shaping protein complexes, although how this process is controlled extracellular signals remains unknown. Here we report that TAK1, a kinase responsive various growth factors cytokines including TGF-β TNF-α, triggers tubulation activating αTAT1, an MT-acetylating...
Proper regulation of mitochondrial dynamics requires dynamin-related protein 1 retrograde movement via GAIP/RGS19-interacting protein-myosin VI transport system.
βIV-Spectrin is a membrane cytoskeletal protein with specialized roles in the nervous system and heart. Recent evidence also indicates fundamental role for βIV-spectrin angiogenesis as its endothelial-specific gene deletion mice enhances embryonic lethality due to hypervascularization hemorrhagic defects. During early vascular sprouting, believed inhibit tip cell sprouting favor of stalk phenotype by mediating VEGFR2 internalization degradation. Despite these essential roles, mechanisms...
Abstract Background Tumor‐associated angiogenesis mediates the growth and metastasis of most solid cancers. Targeted therapies VEGF pathways can effectively block these processes but often fail to provide lasting benefits due acquired resistance complications. Results Recently, we discovered β IV ‐spectrin as a powerful regulator potential new target. We previously reported that is dynamically expressed in endothelial cells (EC) induce VEGFR2 protein turnover during development. Here,...
Insulin signaling in blood vessels primarily functions to stimulate angiogenesis and maintain vascular homeostasis through the canonical PI3K MAPK pathways. However, is a complex process coordinated by multiple other events. Here, we report distinct crosstalk between insulin receptor endoglin/activin receptor-like kinase 1 (ALK1), an endothelial cell-specific TGF-β essential for angiogenesis. While endoglin-ALK1 normally binds or bone morphogenetic protein 9 (BMP9) promote gene regulation...
Dynamic changes in the endoplasmic reticulum (ER) morphology are central to maintaining cellular homeostasis. Microtubules (MT) facilitate continuous remodeling of ER network into sheets and tubules by coordinating with many ER-shaping protein complexes, although how this process is controlled extracellular signals remains unknown. Here we report that TAK1, a kinase responsive numerous growth factors cytokines including TGF-β TNF-α, triggers tubulation activating αTAT1, an MT-acetylating...
Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI
SUMMARY Mitochondrial remodeling is a fundamental process underlying cellular respiration and metabolism. Here we report TAK1 as direct regulator of mitochondrial fusion. activated by variety mitogenic factors, cytokines environmental stimuli, which find induces rapid fragmentation through Mfn2 inactivation. phosphorylates at Ser249, inhibits the binding GTP required for Mfn trans-dimerization membrane Accordingly, expression Mfn2-S249 phosphomimetics (Mfn2-E/D) constitutively promote...