A5088330922- Wound Healing and Treatments
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Fungal Infections and Studies
- Heart Rate Variability and Autonomic Control
- Retinal and Macular Surgery
- Glaucoma and retinal disorders
- Bacterial biofilms and quorum sensing
- Retinal Diseases and Treatments
- Antimicrobial Peptides and Activities
- Retinal Imaging and Analysis
- Antifungal resistance and susceptibility
- Ocular and Laser Science Research
- Cardiovascular and exercise physiology
- Intraocular Surgery and Lenses
- Diabetic Foot Ulcer Assessment and Management
- Birth, Development, and Health
- Non-Invasive Vital Sign Monitoring
- Psoriasis: Treatment and Pathogenesis
- Cytomegalovirus and herpesvirus research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pressure Ulcer Prevention and Management
- Health and Medical Studies
- Pediatric health and respiratory diseases
- Health, Environment, Cognitive Aging
Tohoku University
2015-2025
Iwate Medical University
2025
Gold Coast Hospital
2023
Genomics Research Center, Academia Sinica
2010
Amirkabir University of Technology
2010
Chulalongkorn University
2010
Osaka Rosai Hospital
1999-2008
Keio University
2008
Osaka University
1999
Ehime University
1997
Tumor necrosis factor (TNF)-α is quickly released and initiates inflammation at wound tissues, but its precise role in healing not fully understood. We examined the contribution of this cytokine to early process using a mouse model with full-thickness wounds skin. TNF-α synthesis was detected just after creation, increased during first several hours, reached peak level on day 1, then decreased basal level. In mice treated anti-TNF-α mAb, closure significantly delayed, distances between...
Although many synapse-organizing molecules have been identified <i>in vitro</i>, their functions in mature neurons vivo</i> mostly unexplored. Cbln1, which belongs to the C1q/tumor necrosis factor superfamily, is most recently protein involved synapse formation mammalian CNS. In cerebellum, Cbln1 predominantly produced and secreted from granule cells; <i>cbln1</i>-null mice show ataxia a severe reduction number of synapses between Purkinje cells parallel fibers (PFs), axon bundle cells....
Abstract Low‐energy extracorporeal shock wave ( LE ‐ ESW ) treatment has been shown to accelerate wound repair; however, the mechanisms of remain unclear. In present study, we addressed role endothelial nitric oxide synthase eNOS ). A single accelerated healing wounds in diabetic mice caused by injection streptozotocin. This was accompanied increased expression and vascular growth factor VEGF generation new vessels at tissues. These results raised possibility that may be involved beneficial...
Abstract Wound healing is promoted by the presence of replicating microorganisms adhering to wounded tissue, but precise mechanism not fully understood. In present study, using a rat model with full‐thickness dermal wounds, we examined effect P seudomonas aeruginosa inoculation on wound and role neutrophils infiltrating site. Within 3 days, this bacterium had accelerated re‐epithelialization, epidermal cell proliferation, neo‐vascularization, as well local infiltration neutrophils, which...
Abstract In the wound healing process, neutrophils are first inflammatory cells to move tissues. They sterilize wounds by killing microbes, and they stimulate other immune protect host from infection. contrast, neutrophil‐derived proteases cause damage tissues, so play dual opposite roles in healing. Interleukin‐17A ( IL ‐17A) is a proinflammatory cytokine that promotes recruitment of these cells. The role this process not fully clarified. present study, therefore, we examined how defect...
ABSTRACT Dectin-2 is a C-type lectin receptor that recognizes high mannose polysaccharides. Cryptococcus neoformans , yeast-form fungal pathogen, rich in polysaccharides its cell wall and capsule. In the present study, we analyzed role of host defense against C. infection. gene-disrupted (knockout) (Dectin-2KO) mice, clearance this fungus inflammatory response, as shown by histological analysis accumulation leukocytes infected lungs, were comparable to those wild-type (WT) mice. The...
Caspase recruitment domain-containing protein 9 (CARD9) is an adaptor molecule signal that critical for NF-κB activation and triggered through C-type lectin receptors (CLRs), which are pattern recognition recognize carbohydrate structures. Previous studies have reported Cryptococcus neoformans, a fungal pathogen causes meningoencephalitis in AIDS patients, recognized some CLRs, such as mannose or DC-SIGN. However, the role of CARD9 host defense against cryptococcal infection remains to be...
Interferon (IFN)-γ is mainly secreted by CD4+ T helper 1 (Th1), natural killer (NK) and NKT cells after skin injury. Although IFN-γ well known regarding its inhibitory effects on collagen synthesis fibroblasts in vitro, information limited role wound healing vivo. In the present study, we analyzed how defect of affects healing. Full-thickness wounds were created backs wild type (WT) C57BL/6 IFN-γ-deficient (KO) mice. We percent closure, breaking strength, accumulation leukocytes, expression...
Abstract The wound‐healing process consists of the inflammation, proliferation, and remodeling phases. In chronic wounds, inflammation phase is prolonged with persistent neutrophil infiltration. inflammatory response critically regulated by cytokines chemokines that are secreted from various immune cells. Recently, we showed skin wound healing was delayed impaired under conditions lacking invariant natural killer T (iNKT) cells, an innate lymphocyte potent immuno‐regulatory activity. present...
Acute respiratory distress syndrome (ARDS) is accompanied by severe lung inflammation induced various diseases. Despite the severity of symptoms, therapeutic strategies have been ineffective. High mobility group box 1 (HMGB1), which was identified originally as a DNA binding protein, has proposed mediator acute injury. In addition to its anti-coagulant activity, recombinant thrombomodulin (rTM) possesses an ability suppress inflammatory response through neutralizing HMGB1. T regulatory...
Abstract Objectives This study aims to compare the image processing times of dental cone beam CT (CBCT) images using a remote medical workstation (RW) versus on-premises (OP) and assess its impact on workflow efficiency. Methods Data from 100 CBCT cases were randomly selected processed OP3D VISION 17-19DX (EH Japan Co., Ltd.). In OP environment, OnDemand 3D Dental (Cybermed Inc.) was used local terminal, while RW setup involved workstation—ZIO STATION (Ziosoft connected via 2 Gbps network....
Background: In the process of burn wound healing, promoting healing and suppressing progression by enhancing blood flow is considered essential. Various agents that increase are currently being assessed. Batroxobin (DF-521; Defibrase ® ) a denitrogenating agent extracted from Bothrops moojeni , used as thrombin-like serine protease to improve ischemic conditions. However, it remains unclear how this affects process. study, we conducted analyses define effects batroxobin administration on...
Type I interferons (IFNs) are secreted by many cell types upon stimulation via pattern recognition receptors and bind to IFN-α/β receptor (IFNAR), which is composed of IFNAR1 IFNAR2. Although type IFNs well known as anti-viral cytokines, limited information available on their role during fungal infection. In the present study, we addressed this issue examining effect defects host defense response Cryptococcus neoformans. IFNAR1KO mice, number live colonies was lower immune mediated not only...
The cell walls and capsules of Cryptococcus neoformans , a yeast-type fungal pathogen, are rich in polysaccharides. Dectin-2 is C-type lectin receptor (CLR) that recognizes high-mannose
<h3>AIMS</h3> To evaluate the scanning retinal thickness analyser (RTA), a novel non-invasive imaging instrument, in diagnosing and quantitatively characterising diabetic macular oedema, to investigate relation between central macula measured by RTA other clinical examinations. <h3>METHODS</h3> Central was using 40 normal subjects 60 patients with retinopathy. The reproducibility of measurements evaluated calculating mean inter- intrasession variations. correlated results visual acuity...
IL-17A is a proinflammatory cytokine produced by many types of innate immune cells and Th17 involved in the elimination extracellularly growing microorganisms, yet role this host defense against intracellularly microorganisms not well known. Cryptococcus deneoformans an opportunistic intracellular growth fungal pathogen that frequently causes fatal meningoencephalitis patients with impaired responses. In current study, we analyzed C. infection. was quickly γδT at phase infected lungs....
ABSTRACT Cryptococcus neoformans is an opportunistic fungal pathogen that causes meningoencephalitis in immunocompromised patients. Recently, we reported Toll-like receptor 9 (TLR9) involved host defense against C. : specifically, it detects the pathogen's DNA. In present study, aimed to elucidate mechanisms underlying TLR9-mediated activation of innate immune responses by using URA5 gene, which encodes a virulent component this pathogen. A PCR-amplified 345-bp gene fragment induced...
Objective: Chronic skin wounds are usually colonised with bacteria and subsequent infection may develop. Topical antiseptics commonly used to control bacterial colonisation. The topical antiseptic, 1% polyvinylpyrrolidone-iodine (PVP-I), that is on chronic open remains controversial in the clinical setting because of its cytotoxicity. Here, we tested PVP-I solution against saline determine if it reduces count wound surface within tissue lead reduction. Method: Open were created backs Sprague...
Acute respiratory distress syndrome (ARDS) is a pathological condition that involves diffuse lung injury and severe hypoxemia caused by pulmonary systemic diseases. We have established mouse model of ARDS, developed intratracheal injection α-galactosylceramide (α-GalCer), an activator natural killer T (NKT) cells, followed LPS. In the present study, we used this to investigate regulatory mechanism in early inflammatory response during acute injury. α-GalCer/LPS-treated mice, number CD4+...