A5101550418- Pediatric health and respiratory diseases
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Sleep and Wakefulness Research
- Rheumatoid Arthritis Research and Therapies
- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Hepatitis C virus research
- Helicobacter pylori-related gastroenterology studies
- Hematopoietic Stem Cell Transplantation
- Gastroesophageal reflux and treatments
- melanin and skin pigmentation
- Eosinophilic Esophagitis
- Healthcare Systems and Practices
- Cardiac pacing and defibrillation studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Blood groups and transfusion
- Reproductive System and Pregnancy
- Statistical Methods in Clinical Trials
- Restless Legs Syndrome Research
- Dementia and Cognitive Impairment Research
- Respiratory and Cough-Related Research
- Xenotransplantation and immune response
- Hormonal Regulation and Hypertension
Eisai (Japan)
2014-2022
University of Tsukuba
2006-2010
Since the identification of ligands for human and mouse DNAM-1, emerging evidence has suggested that DNAM-1 plays an important role in T cell– natural killer (NK) cell–mediated recognition lysis tumor cells. However, it remains undetermined whether is involved immune surveillance vivo. We addressed this question by using DNAM-1–deficient mice. cytotoxic lymphocyte (CTL) NK cells showed significantly less activity against ligand-expressing tumors vitro than wild-type (WT) The...
Acute graft-versus-host disease (GVHD) is a life-threatening complication following bone marrow transplantation; however, no effective molecular-targeting therapy has been determined. Here, we show that mice received allogeneic splenocytes deficient in DNAX accessory molecule-1 (DNAM-1) had significantly milder GVHD and lower mortality than those WT splenocytes. Donor CD8 + T cells DNAM-1 showed less proliferation infiltration of the liver intestines recipient produced IFN-γ after coculture...
Leukocyte adhesion molecule leukocyte function-associated antigen (LFA)-1 not only mediates intercellular binding but also delivers co-stimulatory signals in T cells. LFA-1 has been shown to decrease the threshold of TCR signal and an dose required for cell activation proliferation vitro. However, physiological significance role remained unclear. We examined whether decreased vivo. showed here that, although collagen-induced arthritis (CIA) could be induced by immunization challenge with a...
Abstract The objectives of this study were to describe prevalence, incidence, and medications among patients who diagnosed with narcolepsy in Japan using a claims database. Patients identified from January 2010 December 2019 an employment-based health insurance database compiled by JMDC Inc. prevalence incidence estimated annually the overall population age sex employees their dependents aged < 75 years. Medications, examined for each quarter population, modafinil, methylphenidate,...
Background/aim: Lysozyme (mucopeptide N -acetyl-muramyl hydrolase) is widely used as a mucolytic and anti-inflammatory agent in Japan. We evaluated the effects of long-term lysozyme administration on COPD exacerbation. Methods: In 1-year, randomized, double-blind, placebo-controlled, parallel trial, patients with moderate-to-severe one or more episodes exacerbation previous year before enrollment were selected. (270 mg) placebo was administered orally for 52 weeks an add-on to standard...
Objectives: The treatment response according to patient disease activity during Iguratimod therapy for rheumatoid arthritis has not been sufficiently assessed. A post-hoc analysis of post-marketing surveillance was performed. effect evaluated using the European League against Rheumatism (EULAR) criteria. Methods: Disease Activity Score (DAS) 28 assessed at various time points. Patients showing a moderate or good EULAR criteria 24 weeks after start were considered Responders. Propensity score...
Abstract Background The earlier treatment for dementia is important when it diagnosed. annual healthcare costs mild Alzheimer's disease (AD) has been reported to be approximately 250,000 JPY (equivalent 2,400 USD) per person [1], but there were few cost studies associated with cognitive impairment (MCI). This study aimed clarify the incurred MCI using a medical claim database in order find out burden early stage of dementia. Method An administrative Diagnostic Procedure Combination provided...
<b>Background /Aim:</b> Lysozyme hydrochroride (mucopeptide N-acetyl muramyl hydrolase; LYS) is widely used as a mucolytic and anti-airway inflammatory agent in Japan. We evaluated the effects of long-term LYS administration on COPD exacerbation. <b>Method:</b> In 1-year, randomized, double-blind, placebo-control, parallel trial, patients with moderate-to-severe one or more episodes exacerbation 1 year before enrollment were enrolled. 270 mg placebo was orally administered for 52 weeks an...
Objectives: Adverse drug reactions (ADRs) related to liver dysfunction are a common problem in patients with rheumatoid arthritis (RA) receiving iguratimod, but which patient subgroups go on discontinue iguratimod treatment is unclear. A post-hoc analysis of post-marketing surveillance study was performed investigate factors influencing continuation after the onset dysfunction.Methods: Types ADR were compared between whom discontinued or continued accordance judgment patient’s physician...
A post-marketing study was performed on all patients who had started treatment with iguratimod, a conventional synthetic disease-modifying antirheumatic drug approved in Japan. During the period, various safety measures were implemented to reduce risks. We investigated frequency of adverse reactions before and after implementation each measure examine preventive effect these measures. Post-hoc analysis using data from all-case surveillance iguratimod. The subjects receiving iguratimod for...