A5064278005- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Muscle Physiology and Disorders
- Oral microbiology and periodontitis research
- Advanced Glycation End Products research
- Apelin-related biomedical research
- Salivary Gland Disorders and Functions
- Cancer-related gene regulation
- Parkinson's Disease Mechanisms and Treatments
- Pancreatic function and diabetes
- NF-κB Signaling Pathways
- Metabolomics and Mass Spectrometry Studies
- Nutrition and Health in Aging
- Heme Oxygenase-1 and Carbon Monoxide
Brigham Young University
2019-2025
Roseman University of Health Sciences
2016-2017
Abstract Sarcopenia refers to the decline in muscle mass and function that occurs with advancing age. It is driven by alterations multiple cellular processes. AMP‐activated protein kinase (AMPK) a energy sensor opposes many age‐related changes, making it an attractive target for treatment of sarcopenia. This study aimed test effect chronic old mice AMPK‐activating prodrug, AICAR, on treadmill running capacity mass, force production, gene expression, intracellular markers relevant Old (23...
Oral squamous cell carcinoma (OSCC) affects approximately 30,000 people and is associated with tobacco use. Little known about the mechanistic effects of second-hand smoke in development OSSC. The receptor for advanced glycation end-products (RAGE) a surface that upregulated by inhibited semi-synthetic glycosaminoglycan ethers (SAGEs). Our objective was to determine role RAGE during cigarette extract-induced cellular responses use SAGEs as modulating factor Ca9-22 OSCC invasion. cells were...
Objective . Oral inflammatory pathologies are linked to increased oxidative stress, thereby partly explaining their relevance in the etiology of systemic disorders. The purpose this work was determine degree which LPS from Porphyromonas gingivalis , primary pathogen related oral inflammation, altered gingival mitochondrial function and reactive oxygen species generation. Methods Human fibroblast (HGF-1) cells were treated with lipopolysaccharide P. gingivalis. Mitochondrial determined via...
Cigarette smoke exposure compromises health through damaging multiple physiological systems, including disrupting metabolic function. The purpose of this study was to determine the role oral gingiva in mediating deleterious effects cigarette on skeletal muscle Using an vitro conditioned medium cell model, cells were incubated with from gingival treated normal or containing suspended extract (CSE). Following incubation medium, mitochondrial respiration and insulin signaling action determined...
Sarcopenia is a condition defined by loss of muscle mass with aging. It associated changes in many metabolic pathways. One these the mechanistic target rapamycin (mTOR) pathway, which chronically activated aged skeletal under basal conditions. This mTOR hyperactivity thought to deactivate autophagy, leading accumulation defective cell machinery thereby potentially contributing age‐related dysfunction. AMP‐activated protein kinase (AMPK) acts as an inhibitor pathway. AMPK activation generally...
Many fields of study have grappled with the challenge decelerating effects aging. Physical exercise plays a vital role in attenuating impact aging process. While many exercise-induced chemical signaling pathways are not fully understood, AMP-activated protein kinase mediates beneficial adaptations to training. AMPK is activated by accumulation AMP (and ADP) during muscle contraction-induced ATP breakdown. The prodrug AICAR mimics and leads activation increasing concentration analog, ZMP....
Many fields of study have grappled with the challenge decelerating effects aging. Physical exercise plays a vital role in attenuating impact aging process. While many exercise-induced chemical signaling pathways are not fully understood, AMP-activated protein kinase mediates beneficial adaptations to training. AMPK is activated by accumulation AMP (and ADP) during muscle contraction-induced ATP breakdown. The prodrug AICAR mimics and leads activation increasing concentration analog, ZMP....