A5046634163- Melanoma and MAPK Pathways
- Wnt/β-catenin signaling in development and cancer
- PI3K/AKT/mTOR signaling in cancer
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Viral Infectious Diseases and Gene Expression in Insects
- RNA Interference and Gene Delivery
- Cell death mechanisms and regulation
- Genomics and Chromatin Dynamics
- Cancer Mechanisms and Therapy
- Amphibian and Reptile Biology
- Redox biology and oxidative stress
- Cutaneous Melanoma Detection and Management
- Immunotherapy and Immune Responses
- Nuclear Receptors and Signaling
- Immune Cell Function and Interaction
- Plant Virus Research Studies
- Cytokine Signaling Pathways and Interactions
- Synthesis of Tetrazole Derivatives
- Renal cell carcinoma treatment
- Hippo pathway signaling and YAP/TAZ
- Mast cells and histamine
- Chromosomal and Genetic Variations
- RNA Research and Splicing
- Cell Image Analysis Techniques
Universidad Maimónides
2015-2023
Consejo Nacional de Investigaciones Científicas y Técnicas
2015-2022
The Receptor tyrosine kinase-like Orphan 1 (ROR1) is primarily expressed by neural crest cells during embryogenesis. Following a complete downregulation after birth, ROR1 was shown to re-express in various types of cancers. Little known about expression and function melanoma. Here we show that aberrantly both melanoma cell lines tumors its associates with poor Post-Recurrence Survival Using gain- loss-of-function approaches found enhances anchorage-dependent -independent growth cells. In...
Wnt5a signaling has been implicated in the progression of cancer by regulating multiple cellular processes, largely migration and invasion, epithelial-mesenchymal transition (EMT), metastasis. Since also involved inflammatory processes infectious diseases, we addressed role NF-κB, a pivotal mediator responses, context cancer. The treatment melanoma cells with induced phosphorylation NF-κB subunit p65 as well IKK IκB degradation. By using cDNA overexpression, RNA interference, dominant...
The hylid tribe Cophomantini is a diverse clade of Neotropical treefrogs composed the genera Aplastodiscus, Boana, Bokermannohyla, Hyloscirtus, and Myersiohyla. phylogenetic relationships have been comprehensively reviewed in literature, providing suitable framework for study chromosome evolution. Employing different banding techniques, we studied chromosomes 25 species Boana 3 Hyloscirtus; thus providing, first time, data Hyloscirtus 15 Boana. Most showed karyotypes with 2n = 2x 24...
The anti-apoptotic proteins from the Bcl-2 family are important therapeutic targets since they convey resistance to anticancer regimens. Despite suspected functional redundancy among six of this subfamily, both basic studies and approaches have focused mainly on BCL2, Bcl-xL, MCL1. role BCL2L10, another member group, has been poorly studied in cancer never melanoma. We describe here that BCL2L10 is abundantly frequently expressed melanoma cell lines tumor samples. established expression...
Abstract Background Receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a Wnt5a aberrantly expressed in cancer that was shown to either suppress or promote carcinogenesis different tumor types. Our goal study the role of ROR2 melanoma. Methods Gain and loss-of-function strategies were applied biological function Proliferation assays, flow cytometry, western blotting used evaluate cell proliferation changes expression levels cell-cycle markers. The growth assessed xenotransplantation...
The PI3K/Akt and the STAT3 pathways are functionally associated in many tumor types. Both vitro vivo studies have revealed that either biochemical or genetic manipulation of pathway activity induce changes same direction Akt activity. However, implicated mechanism has been poorly characterized. Our goal was to characterize precise linking with other AGC kinases cancer using melanoma cells as a model. We show active is constitutively bound PDK1 promoter positively regulate transcription...
Accumulating evidence points out that sperm carry epigenetic instructions to embryo in the form of retained histones marks and RNA cargo can transmit metabolic behavioral traits offspring. However, mechanisms behind inheritance paternal environment are still poorly understood. Here, we curated male germ cells RNA-seq data analyzed expression profile all known histone lysine writers erasers enzymes across spermatogenesis, unraveling developmental windows at which they upregulated, specific...
Abstract Purpose Receptor tyrosine kinase-like orphan receptor 2 (ROR2) has been shown to play opposite roles in the progression of different tumor types. In melanoma, ROR2 was associate with a more invasive phenotype and contribute experimental lung colonization. However, underlying mechanisms regulated by have not elucidated. More importantly, it established whether is just marker or driver melanoma aggressiveness. Methods Gain loss-of-function experiments were applied study biological...
ABSTRACT Accumulating evidence points out that sperm carry epigenetic instructions to embryo in the form of retained histones marks and RNA cargo can transmit metabolic behavioral traits offspring. However, mechanisms behind inheritance paternal environment are still poorly understood. Here, we curated male germ cells RNA-seq data analyzed expression profile all known histone lysine writers erasers enzymes across spermatogenesis, unraveling developmental windows at which they upregulated,...