A5022061562- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Advanced X-ray and CT Imaging
- Advanced MRI Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Advanced Radiotherapy Techniques
- Radiopharmaceutical Chemistry and Applications
- Cell Image Analysis Techniques
- Ultrasound and Hyperthermia Applications
- Digital Radiography and Breast Imaging
- Lanthanide and Transition Metal Complexes
- Alzheimer's disease research and treatments
- Endodontics and Root Canal Treatments
- Dental Radiography and Imaging
- Parathyroid Disorders and Treatments
- Glioma Diagnosis and Treatment
- Photoacoustic and Ultrasonic Imaging
- Advanced Biosensing Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Molecular Biology Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Functional Brain Connectivity Studies
- Heterotopic Ossification and Related Conditions
University of Tübingen
2012-2024
Siemens (Germany)
2015-2024
University of British Columbia
2020-2024
TH Bingen University of Applied Sciences
2024
Imaging Center
2023
University College London
2019
University of Cambridge
2019
University Hospital of Zurich
2012
University Children's Hospital Tübingen
2012
Hertie Institute for Clinical Brain Research
2012
The frontiers of bioimaging are currently being pushed towards the integration and correlation several modalities to tackle biomedical research questions holistically across multiple scales. Correlated Multimodal Imaging (CMI) gathers information about exactly same specimen with two or more complementary that – combined create a composite view sample (including insights into structure, function, dynamics molecular composition). CMI allows describe processes within their overall...
Especially for neuroscience and the development of new biomarkers, a direct correlation between in vivo imaging histology is essential. However, this comparison hampered by deformation shrinkage tissue samples caused fixation, dehydration paraffin embedding. We used magnetic resonance (MR) computed tomography (CT) to analyze degree on murine brains various fixatives. After using 7 T MRI, animals were sacrificed dissected immediately placed different fixatives, respectively: zinc-based...
Non‐invasive in vivo small animal computed tomography (CT) imaging provides high resolution bone scans but cannot differentiate between soft tissues. For most applications injections of contrast agents (CAs) are necessary. Aim this study was to uncover the advantages and disadvantages commercially available CT CAs (ExiTron nano 12 000 6000, eXIA 160 160XL, Fenestra VC LC) regarding their pharmacokinetics, toxicological side‐effects influence anesthesia on biodistribution, based an injection...
Recently, total-body PET/CT systems with an extended axial field-of-view (aFOV) became commercially available which allow acquiring physiologic information of multiple organs simultaneously. However, the nominal aFOV may clinically not be used effectively due to inherently reduced sensitivity at distal ends aFOV. The aim this study was assess extent useful Biograph Vision Quadra system. A NEMA image quality (IQ) phantom mimicking a standard [18F]FDG examination used. Image contrast and noise...
Abstract Background The high sensitivity and axial coverage of large field view (LAFOV) PET scanners have an unmet potential for total-body research. Despite these technological advances, inherent challenges to scans such as patient motion persist. To provide simulation-derived ground truth information, we developed a digital replica the Biograph Vision Quadra LAFOV PET/CT scanner closely mimicking real event processing image reconstruction. Material methods framework uses GATE model in...
Quantification accuracy and partial volume effect (PVE) of the Siemens Inveon PET scanner were evaluated. The influence transmission source activities (40 160 MBq) on quantification PVE determined. Dynamic range, object size for different sphere sizes, contrast ratios positions in field view (FOV) acquired data reconstructed using algorithms correction methods. activity level total emission FOV strongly influenced attenuation maps. Reconstruction algorithms, methods, location within had a...
To determine the accuracy of locating apical constriction using apex locators.Extracted teeth were micro-CT scanned preoperatively to localize constriction. Electronic length measurements 91 root canals made nine electronic locators (EAL) connected a mounting model. Distances from major foramen recorded at each scale bar EALs, and file was fixed in canal position indicated by EAL be A second scan conducted, distances tip calculated for EAL. The EALs determined with tolerance 0.1, 0.25, 0.5 1...
The standardization of preclinical imaging is a key factor to ensure the reliability, reproducibility, validity, and translatability data. Preclinical has been slowly progressing in recent years mainly performed within single institution, whereas little done regards multicenter between facilities. This study aimed investigate comparability among facilities terms PET data acquisition analysis. In first step, basic scans were obtained 4 different compare their standard protocol for...
Background/Aims: Tumor dissemination is frequent in gastric cancer and implies a poor prognosis.Cure only achievable provided an accurate staging performed at primary diagnosis.In previous studies we were able to show relevant impact of increased phosphoglycerate kinase 1 expression (PGK1; glycolytic enzyme) on invasive properties in-vivo in-vitro.Thus the aim present study was evaluate effect enhanced PGK1 employing magnetic resonance (MR)-imaging combined with positron emission tomography...
Background: The WNK-dependent STE20/SPS1-related proline/alanine-rich kinase (SPAK) regulates the renal thiazide sensitive NaCl cotransporter (NCC) and furosemide Na+,K+,2Cl- (NKCC2) thus participates in regulation of salt excretion, extracellular fluid volume blood pressure. Inhibition NCC leads to anticalciuria. Moreover, is also expressed osteoblasts where it implicated bone mineralization. Osteoblasts further influence mineral metabolism by releasing phosphaturic hormone FGF23. present...
The increasing use of genetically engineered mice as animal models human disease in biomedical research, latest advances imaging technologies, and development novel, highly specific radiolabeled biomarkers provide great potential to study receptor expression gene function vivo mice. (11)C-raclopride is a widely used PET tracer measure striatal D(2) binding was test the feasibility multiple-ligand-concentration assay for quantification.Mice underwent total 4 scans with decreasing activities...
Abstract Background Total-body PET scanners with axial field of views (FOVs) longer than 1 m enable new applications to study multiple organs (e.g., the brain-gut-axis) simultaneously. As spatial resolution and associated partial volume effect (PVE) can vary significantly along FOV, detailed knowledge contrast recovery coefficients (CRCs) is a prerequisite for image analysis interpretation quantitative results. The aim this was determine CRCs, as well voxel noise, isotopes throughout 1.06...
The sensitivity of a PET system highly depends on the axial acceptance angle or maximum ring difference (MRD), which can be particularly high for total-body scanners due to their larger field views (aFOVs). This study aims evaluate impact image quality (IQ) and noise performance when MRD85 (18°), current standard clinical use, is increased MRD322 (52°) Biograph Vision Quadra (Siemens Healthineers).Studies with cylindrical phantom covering 106 cm aFOV an IEC filled 18F, 68Ga 89Zr were...
An avalanche photodiode (APD)-based small animal positron emission tomography (PET)-insert was fully evaluated for its PET performance, as well potential influences on magnetic resonance imaging (MRI) performance. This PET-insert has an extended axial field of view (FOV) compared with the previous design to increase system sensitivity, updated cooling and temperature regulation enable stable reproducible acquisitions. The performance according National Electrical Manufacturers Association...
To validate the use of longitudinal sections against cross using micro-CT for disclosing topography and location apical constriction.Seventy extracted human teeth with 117 completely developed roots were scanned reconstructed at a voxel size 27 μm. The 3DSlicer program was used to navigate parallel long axis canal also rotate tilt views. Each root evaluated in both mesio-distal bucco-lingual planes. Constriction topographies identified as described literature. In each canal, number different...
The fundamental principle of experimental design is to ensure efficiency and efficacy the performed experiments. Therefore, it behoves researcher gain knowledge technological equipment be used. This should include an understanding instrument quality control assurance requirements avoid inadequate or spurious results due instrumentation bias whilst improving reproducibility. Here, important role preclinical positron emission tomography/computed tomography scanner's required presented along...