A5021157430- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Marine Sponges and Natural Products
- SARS-CoV-2 and COVID-19 Research
- Traditional and Medicinal Uses of Annonaceae
- Advanced Glycation End Products research
- Nitric Oxide and Endothelin Effects
- Medical and Biological Ozone Research
- COVID-19 Clinical Research Studies
- Atrial Fibrillation Management and Outcomes
- Pharmacological Effects of Natural Compounds
- Nanoplatforms for cancer theranostics
- Synthesis and bioactivity of alkaloids
- Peptidase Inhibition and Analysis
- Adenosine and Purinergic Signaling
- Coral and Marine Ecosystems Studies
- Computational Drug Discovery Methods
- Cephalopods and Marine Biology
- Inflammation biomarkers and pathways
- Cardiac Arrhythmias and Treatments
- Phosphodiesterase function and regulation
- Aquaculture disease management and microbiota
- Cardiac Valve Diseases and Treatments
Chang Gung University of Science and Technology
2022-2024
Chang Gung University
2022-2024
Overwhelming neutrophil activation and oxidative stress significantly contribute to acute respiratory distress syndrome (ARDS) pathogenesis. However, the potential of repurposing ribociclib, a cyclin-dependent kinase 4 6 (CDK4/6) inhibitor used clinically in cancer treatment, for treating neutrophilic ARDS remains uncertain. This study illustrated ability underlying mechanism ribociclib inflammation.
Lonicerae japonicae flos (LJ) is an Asian traditional herb that used as a dietary supplement, tea, and beverage to clear heat quench thirst. However, no studies investigated its effect on activated human neutrophils, which played crucial role in the bad prognosis of coronavirus disease 2019 (COVID-19) patients by aggravating lung inflammation respiratory failure. Herein, we evaluated anti-inflammatory LJ ethanol extract (LJEE) neutrophils N-formyl-methionyl-leucyl-phenylalanine (fMLF). Our...
ABSTRACT The recent outbreak of Omicron strains coronavirus disease urged the search for novel treatments from natural products such as Epilobium species. present work reports a comparative HPLC‐DAD study polyphenolic composition crude extracts angustifolium and hirsutum . Oenothein B, gallic acid, hyperoside, isoquercitin were dominant phenolic compounds. E. methanol extract showed high radical scavenging activity demonstrated by HPLC‐ABTS assay due to its richness in polysaccharide‐rich...
Non-valvular atrial fibrillation (NVAF) is a common form of cardiac arrhythmia that affects 1-1.5% adults and roughly 10% elderly with dysphagia. Apixaban an anticoagulant referred to as factor Xa inhibitor, which has been shown reduce the risk stroke systemic embolism in cases NVAF. Our objective current study was formulate orally disintegrating film facilitate administration apixaban patients who have difficulty swallowing. Researchers used wide variety cellulose-based or...
The fruit of Tetradium ruticarpum (TR) is commonly used in Chinese herbal medicine and it has known antiproliferative antitumor activities, which can serve as a good source functional ingredients. Although some compounds are reported to be present TR fruit, most studies only focused on limited range metabolites. Therefore, this study, the activity different extracts was examined, potentially were highlighted by applying an untargeted liquid chromatography-tandem mass spectrometry...
The pathogenesis of acute respiratory distress syndrome (ARDS) is very complex. Patients with ARDS still suffer high mortality rates. Infiltration and activation neutrophils in lungs are critical pathogenic factors ARDS. In this study, we demonstrate that meso-dihydroguaiaretic acid (MDGA), a natural lignan, inhibits inflammatory responses human ameliorates mice. MDGA inhibited superoxide anion generation elastase release various G-protein coupled receptor agonists-induced neutrophils....
Abstract This study aims to develop new molecular structures as potential therapeutic agents against COVID-19, utilizing both in silico and vitro studies. Potential targets of cepharanthine (CEP) COVID-19 reveal its underlying mechanism action were evaluated using screening experiments. A library molecules was docked into the receptor binding domain SARS-CoV-2 spike glycoprotein complex with receptor, human ACE2, identify promising compounds. Receptor-oriented docking performed most likely...