A5046457789- Immunotherapy and Immune Responses
- Prostate Cancer Treatment and Research
- Epigenetics and DNA Methylation
- Health disparities and outcomes
- vaccines and immunoinformatics approaches
- Grit, Self-Efficacy, and Motivation
- Climate Change and Health Impacts
- Animal Ecology and Behavior Studies
- Poisoning and overdose treatments
- Health, psychology, and well-being
- RNA Interference and Gene Delivery
University of Wisconsin Carbone Cancer Center
2016-2022
University of Wisconsin–Madison
2020-2022
Council of State and Territorial Epidemiologists
2022
Minnesota Department of Health
2022
Downregulation of HLA class I (HLA-I) impairs immune recognition and surveillance in prostate cancer may underlie the ineffectiveness checkpoint blockade. However, molecular mechanisms regulating HLA-I loss have not been fully explored. Here, we conducted a comprehensive analysis genomic, epigenomic gene expression alterations primary metastatic human cancer. Loss was associated with repressive chromatin states including DNA methylation, histone H3 tri-methylation at lysine 27, reduced...
Climate change is an urgent public health issue that impacting locally and across the world. Healthcare professionals are on front lines for health, caring people affected by climate change; yet few studies have assessed their knowledge experiences of local effects. The purpose this study was to improve our understanding impacts in Minnesota from perspective healthcare professionals. An electronic survey administered Department Health (MDH) a convenience sample Board-certified nurses...
Immune tolerance to self-antigens can limit robust anti-tumor immune responses in the use of tumor vaccines. Expression novel associated antigens improve recognition and lysis cells. The cancer-testis antigen (CTA) family proteins has been hypothesized be an ideal class due tumor-restricted expression, a subset which have found induce antibody patients with prostate disease. We demonstrate that CTA expression is highly inducible five different Prostate Cancer (PC) cell lines using...
Abstract Downregulation of HLA class I (HLA-I) impairs immune recognition and surveillance in prostate cancer may underlie the ineffectiveness checkpoint blockade. However, molecular mechanisms regulating HLA-I loss have not been fully explored. Here, we conducted a comprehensive analysis genomic, epigenomic gene expression alterations primary metastatic human cancer. Loss was associated with repressive chromatin states including DNA methylation, histone H3 tri-methylation at lysine 27,...