A5063401170- Neuroinflammation and Neurodegeneration Mechanisms
- Extracellular vesicles in disease
- Dietary Effects on Health
- Antioxidant Activity and Oxidative Stress
- Infant Nutrition and Health
- Inflammatory Bowel Disease
- Heme Oxygenase-1 and Carbon Monoxide
- Neonatal Respiratory Health Research
- Immune cells in cancer
- Circular RNAs in diseases
- Gut microbiota and health
- Curcumin's Biomedical Applications
- Inflammasome and immune disorders
- Adipose Tissue and Metabolism
- MicroRNA in disease regulation
- Tryptophan and brain disorders
- Anesthesia and Neurotoxicity Research
- Inflammation biomarkers and pathways
University of Foggia
2023-2025
University of Bari Aldo Moro
2022
Cell-to-cell communication is essential for the appropriate development and maintenance of homeostatic conditions in central nervous system. Extracellular vesicles have recently come to forefront neuroscience as novel vehicles transfer complex signals between neuronal cells. are membrane-bound carriers packed with proteins, metabolites, nucleic acids (including DNA, mRNA, microRNAs) that contain elements present cell they originate from. Since their discovery, extracellular been studied...
Microglia, the resident macrophage-like population in central nervous system, play a crucial role pathogenesis of many neurodegenerative disorders by triggering an inflammatory response that leads to neuronal death. Neuroprotective compounds treat or prevent diseases are new field study modern medicine. Microglia activated stimuli. The various is closely related constant activation microglia due their fundamental as mediator inflammation brain environment. α-Tocopherol, also known vitamin E,...
Neurodegenerative diseases are characterized by progressive loss of neurons and persistent inflammation. Neurons terminally differentiated cells, lost cannot be replaced since neurogenesis is restricted to only two neurogenic niches in the adult brain, whose potential decreases with age. In this regard, astrocytes reprogramming into may represent a promising strategy for restoring rebuilding neural circuits. To date, many anti-inflammatory agents have been shown reduce neuroinflammation;...
Extracellular vesicles (EVs) represent a heterogeneous group of membranous structures derived from cells that are released by all cell types, including brain cells. EVs now thought to be an additional mechanism intercellular communication. Both under normal circumstances and following the addition proinflammatory stimuli, microglia release EVs, but contents these two types different. Microglia considered brain-resident immune involved in surveillance inflammatory responses central nervous...
Neuroinflammation is defined as an immune response involving various cell types, particularly microglia, which monitor the neuroimmune axis. Microglia activate in two distinct ways: M1, pro-inflammatory and capable of inducing phagocytosis releasing factors, M2, has anti-inflammatory properties. Inflammasomes are large protein complexes that form to internal danger signals, activating caspase-1 leading release cytokines such interleukin 1β. Irisin, a peptide primarily released by muscles...