A5082805935- Forensic Toxicology and Drug Analysis
- Cannabis and Cannabinoid Research
- Psychedelics and Drug Studies
- Opioid Use Disorder Treatment
- Poisoning and overdose treatments
- Alcohol Consumption and Health Effects
- Neurotransmitter Receptor Influence on Behavior
- Metabolomics and Mass Spectrometry Studies
- Analytical Chemistry and Chromatography
- Anesthesia and Sedative Agents
- Mass Spectrometry Techniques and Applications
- Veterinary Pharmacology and Anesthesia
- Advanced Chemical Sensor Technologies
- Music and Audio Processing
- Treatment of Major Depression
- Prenatal Substance Exposure Effects
- Analytical Methods in Pharmaceuticals
- Substance Abuse Treatment and Outcomes
- Pain Management and Opioid Use
- Speech and Audio Processing
- Forensic and Genetic Research
- Alkaloids: synthesis and pharmacology
- Epilepsy research and treatment
- Speech Recognition and Synthesis
- Pharmacological Effects and Toxicity Studies
Fredric Rieders Family Foundation
2016-2025
Institute of Forensic Science
2016-2025
Foundation Center
2025
RTI International
2024
Thomas Jefferson University
2021-2024
Conference Board
2024
American Academy of Forensic Sciences
2024
National Institute of Justice
2024
National Institute of Standards
2024
National Institute of Standards and Technology
2024
Following series of synthetic cannabinoid and cathinone derivatives, the illicit drug market has begun to see increased incidence opioids including fentanyl its other chemically unrelated opioid agonists AH-7921 MT-45. Among most frequently encountered compounds in postmortem casework have been furanyl (N-(1-(2-phenylethyl)-4-piperidinyl)-N-phenylfuran-2-carboxamide, Fu-F) U-47700 (trans-3,4-dichloro-N-(2-(dimethylamino)cyclohexyl)-N-methylbenzamide). Both drugs reported be present heroin...
Illicit opioids, consisting largely of fentanyl, novel synthetic and adulterants, are the primary cause drug overdose fatality in United States. Xylazine, an alpha-2 adrenergic agonist veterinary tranquilizer, is being increasingly detected among decedents following illicit opioid overdose. Clinical outcomes non-fatal involving xylazine unexplored. Therefore, emergency department patients with overdose, we evaluated clinical outcome differences for without exposures.
The present invention computer method and apparatus determines music similarity by generating a K-means (instead of Gaussian) cluster signature beat for each piece music. the is included in subsequent distance measurement.
We reviewed a series of deaths in which methamphetamine was detected the decedent's blood. Analysis postmortem whole blood performed by gas chromatography/mass spectrometry with limit quantitation 0.05 mg/L. Methamphetamine 146 cases; 52 were drug caused, i.e., death direct toxic effects caused or contributed to death, 92 classified as related, demonstrated blood, but did not directly cause death. A large proportion resulted from homicidal (27%) suicidal (15%) violence. An examination...
MT-45 (1-cyclohexyl-4-(1,2-diphenylethyl)piperazine) is just one of the many novel psychoactive substances (NPS) to have reached recreational drug market in twenty-first century; it however, first designer opioids achieve some degree popularity, a currently dominated by synthetic cannabinoids and stimulants. A single fatality involving etizolam described. method for quantitation whole blood using liquid chromatography–tandem mass spectrometry was developed validated. The linear range...
Methoxyacetylfentanyl and cyclopropylfentanyl are two of the newest illicit opioids that infiltrating heroin market. were reported by Drug Enforcement Administration (DEA) in their third quarter report 2017 to have been chemically identified seven five times, respectively, from drug evidence analyzed DEA's lab system; Q3 was first time system, while methoxyacetylfentanyl one Q2 2017. A method developed using liquid chromatography tandem mass spectrometry for quantitation fentanyl,...
Synthetic cannabinoid agonists are chemically diverse with multiple analogs gaining popularity as drugs of abuse. We report on the use thin layer chromatography, gas chromatography mass spectrometry, high-performance liquid and time flight spectrometry for identification quantitation these pharmacologically active chemicals in street drug dosage forms. Using approaches, we have identified synthetic cannabinoids JWH-018, JWH-019, JWH-073, JWH-081, JWH-200, JWH-210, JWH-250, CP47,497 (C=8)...
Abstract The synthetic opioid landscape continues to change as non-fentanyl-related substances appear in forensic toxicology casework. Among the newest opioids emerge is isotonitazene, an analogue of a benzimidazole class analgesic compounds. Isotonitazene active and potent opioid, but extent which this compound causing toxicity among drug users was previously unknown. This report describes confirmation quantitation isotonitazene blood, urine vitreous fluid through standard addition, well...
The following report summarizes a study performed on seized drug exhibits collected in two U.S. states to evaluate the presence and identification of cutting agents. Aliquots materials from Kentucky (n = 200) Vermont 315) were prepared using dilute-and-shoot procedure. Initial analysis was gas chromatography-mass spectrometry (GC-MS) followed by liquid chromatography quadrupole time-of-flight mass (LC-QTOF). Active compounds detected overall included caffeine (31.0%), quinine/quinidine...
Abstract Synthetic opioids constitute one of the fastest-growing groups new psychoactive substances (NPS) worldwide. With fentanyl analogues being increasingly controlled via classwide scheduling, many non-fentanyl-related are now emerging on recreational opioid market, rendering landscape highly complex and dynamic. While compounds entering supply in rapid unpredictable manners, some recent patterns have become apparent. Many these newly pirated from early patent literature and/or research...
Xylazine, an alpha-2 receptor agonist used in veterinary medicine for its sedative and muscle-relaxant effects, has been reported forensic toxicology casework since the 1980s. It is not approved human use, but it as adulterant heroin illicit fentanyl. The prevalence concentrations of xylazine 2.5 years (January 2019-June 2021) driving under influence drugs (DUID) medico-legal death investigation (MDI) cases was investigated, including other detected combination with xylazine. Of over 170,000...
Importance Synthetic opioids, such as the fentanyl analogue and nitazene drug class, are among fastest growing types of opioids being detected in patients emergency department (ED) with illicit opioid overdose (OD). However, clinical outcomes from OD novel potent (NPOs), specifically nitazenes, unknown aside small case series. Objective To determine naloxone administration sequelae who were ED NPO compared OD. Design, Setting, Participants This is a cohort study subgroup analysis adults...
Abstract 2-Benzylbenzimidazole ‘nitazene’ opioids are presenting a growing threat to public health. Although various nitazenes were previously studied, systematic comparisons of the effects different structural modifications 2-benzylbenzimidazole core structure on μ-opioid receptor (MOR) activity limited. Here, we assessed in vitro structure–activity relationships 9 uncharacterized alongside known analogues. Specifically, focused MOR activation by ‘ring’ substituted analogues (i.e., N...
Abstract Identification of N,N-dimethylpentylone (DMP) in counterfeit “Ecstasy” and “Molly” tablets poses risk to public health due its adverse effects. Little information is available regarding the pharmacological activity or relevant blood tissue concentrations DMP, even less known about other structurally related beta-keto methylenedioxyamphetamine analogs on recreational drug markets, such as N-propyl butylone. Here, a novel toxicological assay utilizing liquid chromatography–tandem...
Systems to automatically provide a representative summary or 'key phrase' of piece music are described. For 'rock' song with 'verse' and 'chorus' sections, we aim return the chorus in any case most repeated hence memorable section. The techniques less applicable more complicated structure although possibly our general framework could still be used different heuristics. Our process consists three steps. First parameterize into features. Next use these features discover structure, either by...
A sensitive and specific method for the quantification of JWH-018, JWH-073, JWH-250 qualitative identification JWH-019 in whole blood was developed validated. Samples fortified with JWH-018-d9 JWH-073-d9 underwent liquid-liquid extraction were analyzed by liquid chromatography-positive ion electrospray ionization-tandem mass spectrometry. Two transitions monitored all analytes except JWH-250, which there only one available transition. did not meet stringent requirements quantitative...
Synthetic cannabinoid drugs do not cross react on traditional marijuana immunoassay tests, preventing their use in large scale drug screening programs. This paper describes the validation and performance characteristics of two enzyme linked immunosorbent assays designed to detect common synthetic cannabinoids urine, JWH-018 JWH-250. The assay has significant cross-reactivity with several metabolites, whereas JWH-250 limited cross-reactivity. are calibrated at 5 ng/mL 5-OH metabolite 4-OH...
In recent years, there has been a growth in reports of antiepileptic drugs (AEDs) being misused on their own or combination with other abuse variety toxicological case types such as drug abuse, suicide, overdose and facilitated crime. To our knowledge, are no simultaneous quantification methods for the analysis most commonly encountered AEDs postmortem whole blood clinical plasma/serum samples at same time. A simple, accurate cost-effective liquid chromatography-tandem mass spectrometric...