A5019258077- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- SARS-CoV-2 and COVID-19 Research
- Cancer Immunotherapy and Biomarkers
- COVID-19 Clinical Research Studies
- Research on Leishmaniasis Studies
- Immune responses and vaccinations
- Viral Infections and Immunology Research
- Cutaneous Melanoma Detection and Management
- Diabetes and associated disorders
- Vaccine Coverage and Hesitancy
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
Universidad Nacional Autónoma de México
2022-2024
Hospital de Especialidades
2022-2024
Centro Medico Nacional Siglo XXI
2022-2024
Mexican Social Security Institute
2022-2024
Background Melanoma, the most lethal form of skin cancer, has undergone a transformative treatment shift with advent checkpoint blockade immunotherapy (CBI). Understanding intricate network immune cells infiltrating tumor and orchestrating control melanoma response to CBI is currently utmost importance. There evidence underscoring significance tissue-resident memory (TRM) CD8 T classic dendritic cell type 1 (cDC1) in cancer protection. Transcriptomic studies also support existence TCF7 +...
T-cell exhaustion is a key stage in chronic infections since it limits immunopathology, but also hinders the elimination of pathogens. Exhausted T (Tex) cells encompass dynamic subsets, including progenitor that sustain long-term immunity through their memory/stem like properties, and terminally-differentiated cells, resembling so-called Tex cells. The presence leishmaniasis has been reported humans murine models, yet heterogeneity remains unexplored. Using flow cytometry, we identified...
Innate immune training is a metabolic, functional, and epigenetic long-term reprogramming of innate cells triggered by different stimuli. This imprinting also reaches hematopoietic precursors in the bone marrow to sustain memory-like phenotype. Dendritic (DCs) can exhibit responses, enhanced upon subsequent exposure pathogen; however, whether this lineage stimulus-restricted still being determined. Nevertheless, functional consequences DCs on adaptive protective response against...
Introduction Several effective vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed and implemented in the population. However, current production capacity falls short of meeting global demand. Therefore, it is crucial to further develop novel vaccine platforms that can bridge distribution gap. AVX/COVID-12 a vector-based utilizes Newcastle Disease virus (NDV) present SARS-CoV-2 spike protein immune system. Methods This study aims analyze antigenicity...
Acral melanoma (AM) is the most common in non-Caucasian populations, yet it remains largely understudied. As AM lacks UV-radiation mutational signatures that characterize other cutaneous melanomas, considered devoid of immunogenicity and rarely included clinical trials assessing novel immunotherapeutic regimes aiming to recover antitumor function immune cells. We studied a Mexican cohort patients from Institute Social Security (IMSS) (n = 38) found an overrepresentation (73.9%). developed...
Abstract Several effective vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed and implemented in the population. However, current production capacity falls short of meeting global demand. Therefore, it is crucial to further develop novel vaccine platforms that can bridge distribution gap. AVX/COVID-12 a vector-based utilizes Newcastle Disease virus (NDV) present SARS-CoV-2 spike protein immune system. This study analyses antigenicity candidate by...