A5035460082- Head and Neck Cancer Studies
- Estrogen and related hormone effects
- Cancer-related molecular mechanisms research
- Computational Drug Discovery Methods
- Hepatocellular Carcinoma Treatment and Prognosis
- Viral-associated cancers and disorders
- Lung Cancer Treatments and Mutations
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Synthesis and biological activity
- Cancer survivorship and care
- Cytokine Signaling Pathways and Interactions
- Head and Neck Surgical Oncology
- Radiation Dose and Imaging
- Hepatitis B Virus Studies
- Colorectal Cancer Treatments and Studies
- Advanced Radiotherapy Techniques
- Lung Cancer Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Pancreatic and Hepatic Oncology Research
- Nuclear Structure and Function
- Colorectal and Anal Carcinomas
- Diversity and Impact of Dance
Johns Hopkins University
2025
University of Hong Kong
2015-2022
University of Hong Kong - Shenzhen Hospital
2021-2022
Queen Mary Hospital
2009-2021
Chinese University of Hong Kong
2018-2021
Queen Elizabeth Hospital
2002
The eighth edition of the American Joint Committee on Cancer (AJCC)/Union for International Control (UICC) stage classification (TNM) nasopharyngeal carcinoma (NPC) was launched. It remains unknown if incorporation nonanatomic factors into would better predict survival. We prospectively recruited 518 patients with nonmetastatic NPC treated radical intensity-modulated radiation therapy ± chemotherapy based TNM. Recursive partitioning analysis (RPA) incorporating pretreatment plasma...
Background and Aims There are no prospective data on stereotactic body radiation therapy (SBRT) as a bridge to liver transplantation for HCC. This study aimed evaluate the efficacy safety of SBRT bridging therapy, with comparison transarterial chemoembolization (TACE) high‐intensity focused ultrasound (HIFU). Approach Results Patients were prospectively enrolled under standardized protocol from July 2015 compared retrospective cohort patients who underwent TACE or HIFU 2010. The primary...
Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC) in endemic regions may have undetectable plasma EBV DNA.We prospectively recruited 518 patients with non-metastatic NPC and measured their pre-treatment DNA. The stage distribution prognosis between DNA-negative (0-20 copies/ml) DNA-positive (>20 following radical treatment were compared.Seventy-eight (15.1%) DNA-negative, 62 this subset (12.0%) had 0 copy/ml. Only 23/78 (29.5%) advanced (stage III-IVA) strong encoded RNA...
<b><i>Background:</i></b> Hepatocellular carcinoma (HCC) is highly prevalent in Hong Kong due to the high prevalence of chronic hepatitis B infection. Liver cancer fourth most common and third cause death. Due case load, there a level local expertise treating HCC, full spectrum treatment modalities available. This document summarizes how these should be used based on latest evidence. <b><i>Summary:</i></b> In 2 meetings held early 2017,...
Abstract Cancer‐related fatigue (CRF) is common in women with breast cancer, but little known of its relationship perceived stress. We conducted a cross‐sectional study to explore the associations CRF stress, anxiety, depression, pain and sleep quality 133 Chinese (aged 25–68 years) early stage cancer. The majority had completed surgery chemotherapy were awaiting radiotherapy. Self‐administered questionnaires consisting Brief Fatigue Inventory, Perceived Stress Scale‐10, Hospital Anxiety...
Purpose: Adjuvant tamoxifen treatment revolutionized the management of estrogen receptor (ER)-positive breast cancers to prevent cancer recurrence; however, drug resistance compromises its clinical efficacy. The mechanisms underlying are not fully understood, and no robust biomarker is available reliably predict those who will be resistant. Here, we study BQ323636.1, a novel splice variant NCOR2 gene, evaluate efficacy in predicting patients with cancer.Experimental Design: A monoclonal...
Background: The fluoropyrimidine anticancer drug, especially 5- fluorouracil (5-FU) and its prodrug capecitabine are still being the backbone of chemotherapeutic regimens for colorectal cancer. Dihydropyrimidine dehydrogenase (DPD) is crucial enzyme in catabolism 5-FU. Over past 30 years, there substantial clinical evidence showing that DPD deficiency strongly associated with severe fatal fluoropyrimidine-induced toxicity. Patients methods: A 49-year-old lady resected stage III carcinoma...
Abstract Purpose/Objective Controversy exists regarding the management of cervical lymph node metastases from occult primary. Oncologists face a major challenge in adopting an optimal approach. This study attempted to compare clinical course two different histologic findings this disease entity. Materials and Methods A retrospective analysis was performed for all patients referred our institution between 1988 1998 with unknown Case records consecutive unselected histologically confirmed...
Introduction: The prognostic role of plasma Epstein-Barr virus (EBV) DNA clearance when intensity-modulated radiotherapy (IMRT) and the 8th edition American Joint Committee on Cancer (AJCC)/Union for International Control (UICC) TNM Staging Classification are fully implemented remains undeciphered. We investigated if its half-life during radical treatment non-metastatic nasopharyngeal carcinoma (NPC) was an early prognosticator. Patients methods: with previously untreated NPC were...
Advanced inoperable hepatocellular carcinoma (HCC) conferring a grave prognosis may benefit from yttrium-90 ((90)Y) radioembolization.Thirty patients with advanced HCC including those any lesion >8 cm in maximal diameter or multiple bi-lobar lesions (totally more than five lesions), portal vein thrombosis treated radioembolization were reviewed. Treatment efficacy and safety evaluated. Univariate multivariate analyses performed for identifying potential prognostic factors.After median...
Abstract Background Tuberculosis (TB) reactivation has been increasingly identified following immune checkpoint inhibitor (ICI) therapy for cancer patients. However there no report on TB in the gastrointestinal tract. In report, we describe a patient who developed ileitis after pembrolizumab her metastatic nasopharyngeal carcinoma (NPC). Rechallenge with its temporary interruption together anti-TB produced continuous tumor response but without further reactivation. Case presentation A...
To describe a method to reduce the external radiation exposure emitted from patient after liver-directed radioembolization using 90Y glass microspheres, quantitatively estimate occupational dose of medical personnel providing care radioembolized with use and discuss patients who are adjacent if needs hospitalization.A lead-lined blanket lead equivalence 0.5 mm was used cover abdomen immediately procedure, in order patient. The interventional radiologist rod-type puncture site compressor for...
The purpose of this study was to directly measure, using thermoluminescent dosimeters, the radiation doses received by team members performing (90)Y-ibritumomab tiuxetan administration. occupational associated with two injection methods for patient administration - an automatic syringe driver and box were compared. risks, namely cancer induction hereditary effect, also estimated from results compared risk factors recommended International Commission on Radiological Protection publication...
(1) Background: NPC patients with de novo distant metastasis appears to be a heterogeneous group who demonstrate wide range of survival, as suggested by growing evidence. Nevertheless, the current 8th edition TNM staging (TNM-8) grouping all these into M1 category is not able identify their survival differences. We sought any anatomic and non-anatomic subgroups in this study. (2) Methods: Sixty-nine treatment-naive (training cohort) were prospectively recruited from 2007 2018. performed...
6524 Background: The prognosis of de novo previously untreated metastatic (M1) nasopharyngeal carcinoma (NPC) at diagnosis is poor, and the role consolidative intensity-modulated radiation therapy (IMRT) to primary tumor neck following first-line palliative chemotherapy remains unknown. We report a phase II study IMRT after in M1 NPC. Methods: Consolidative was given prospectively recruited patients whose NPC did not progress 6 cycles with gemcitabine cisplatin. objective overall survival...
Primary peritoneal ependymoma is an exceedingly rare tumour with only four cases reported in the literature. It typically follows indolent disease course. We describe a case of metastatic primary which was treated chemotherapy and radiotherapy resulting prolonged survival to date for 10 years. Case Presentation. The patient 23-year-old female on presentation. She presented right upper quadrant pain associated abdominal mass. Computed tomography demonstrated large mass displacing liver....