About
Contact & Profiles
A5085890558
Research Areas
- Genetics and Neurodevelopmental Disorders
- Telomeres, Telomerase, and Senescence
- Genomics and Chromatin Dynamics
Massachusetts Institute of Technology
2022
Down syndrome (DS) is a genetic disorder driven by the triplication of chromosome 21 (T21) and characterized wide range neurodevelopmental physical disabilities. Transcriptomic analysis tissue samples from individuals with DS has revealed that T21 induces genome-wide transcriptional disruption. However, consequences on nuclear architecture its interplay transcriptome remain unknown. In this study, we find unlike human induced pluripotent stem cells (iPSCs), iPSC-derived neural progenitor...
10.1016/j.stem.2021.12.002
article
EN
cc-by-nc-nd
Cell stem cell
2022-01-01
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