A5012448331- SARS-CoV-2 and COVID-19 Research
- Immunodeficiency and Autoimmune Disorders
- Tuberculosis Research and Epidemiology
- vaccines and immunoinformatics approaches
- Immune responses and vaccinations
- Water Resources and Governance
- Immunotherapy and Immune Responses
- Romani and Gypsy Studies
- Inflammatory Bowel Disease
- COVID-19 epidemiological studies
- SARS-CoV-2 detection and testing
- Respiratory viral infections research
- Biosimilars and Bioanalytical Methods
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 Clinical Research Studies
- Microscopic Colitis
- Systemic Lupus Erythematosus Research
- Celiac Disease Research and Management
Jenner Institute
2021-2024
University of Oxford
2020-2024
Virginia Tech
2017-2018
Biocom
2017-2018
Mycobacterium tuberculosis is the main causative agent of tuberculosis. BCG, only licensed vaccine, provides inadequate protection against pulmonary Controlled human infection models are useful tools for vaccine development. We aimed to determine a safe dose aerosol-inhaled live-attenuated bovis BCG as surrogate M infection, then compare safety and tolerability established using intradermally administered BCG.
A SARS-CoV-2 controlled human infection model (CHIM) has been successfully established in seronegative individuals using a dose of 1×10
<h2>Summary</h2><h3>Background</h3> BCG confers reduced, variable protection against pulmonary tuberculosis. A more effective vaccine is needed. We evaluated the safety and immunogenicity of candidate regimen ChAdOx1 85A–MVA85A compared with revaccination among Ugandan adolescents. <h3>Methods</h3> After 85A dose escalation age de-escalation, we did a randomised open-label phase 2a trial healthy adolescents aged 12–17 years, who were vaccinated at birth, without evident tuberculosis...
The immunogenicity of the candidate tuberculosis (TB) vaccine MVA85A may be enhanced by aerosol delivery. Intradermal administration was shown to safe in adults with latent TB infection (LTBI), but data are lacking for aerosol-delivered vaccines this population. We carried out a Phase I trial evaluate safety and delivered UK LTBI (NCT02532036). Two volunteers were recruited, well-tolerated no concerns. Aerosolised vaccination induced mycobacterium- vector-specific IFN-γ blood...
ABSTRACT Understanding and eliciting protective immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an urgent priority. To facilitate these objectives, we have profiled the repertoire of human leukocyte antigen class II (HLA-II)-bound peptides presented by HLA-DR diverse monocyte-derived dendritic cells pulsed with SARS-CoV-2 spike (S) protein. We identify 209 unique HLA-II-bound peptide sequences, many forming nested sets, which map sites throughout S...
<ns5:p><ns5:bold>Background</ns5:bold>: This study explores how the Roma in Romania, EU’s most concentrated population, are faring terms of a number quality life indicators, including poverty levels, healthcare, education, water, sanitation, and hygiene. It further role synthetic populations modelling identifying at-risk delivering targeted aid.</ns5:p><ns5:p><ns5:bold>Methods</ns5:bold>: 135 surveys were conducted across five geographically diverse Romanian communities. Household...
<ns4:p><ns4:bold>Background</ns4:bold>: This study explores how the Roma in Romania, EU’s most concentrated population, are faring terms of a number quality life indicators, including poverty levels, healthcare, education, water, sanitation, and hygiene.</ns4:p><ns4:p><ns4:bold>Methods</ns4:bold>: 135 surveys were conducted across five geographically diverse Romanian communities. Household participants selected through comprehensive random walk method. Analyses on all data using Pandas for...
Abstract Background Anti-TNF therapy is established as a mainstay in IBD management. Recent data raise controversies regarding efficacy of these agents, sustainability response, and identification factors that may influence outcomes, including dose escalation need for long-term concurrent immunosuppression (Lancet Gastro.Hep.2019;4:341). Methods We report retrospective cohort study 699 patients on anti-TNF at our centre between 2005-2022. Clinical were obtained from patient records pharmacy...
<ns4:p><ns4:bold>Background</ns4:bold>: This study explores how the Roma in Romania, EU’s most concentrated population, are faring terms of a number quality life indicators, including poverty levels, healthcare, education, water, sanitation, and hygiene.</ns4:p><ns4:p><ns4:bold>Methods</ns4:bold>: 135 surveys were conducted across five geographically diverse Romanian communities. Household participants selected through comprehensive random walk method. Analyses on all data using Pandas for...
<h3>Introduction</h3> Controlled human infection models (CHIMs) involve the deliberate exposure of individuals to a pathogen in controlled environment. Respiratory organism CHIMs have been utilised further understanding on kinetics or host-pathogen immunobiology plus enabling expedited testing vaccines and therapeutics. A SARS-CoV-2 CHIM has undertaken seronegative volunteers utilising dose 10TCID<sub>50</sub> pre-Alpha virus strain. Sustained was seen 53% (18/34) with infectious persisting...