A5031674089- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Malaria Research and Control
- SARS-CoV-2 detection and testing
- Immunotherapy and Immune Responses
- Neuroscience of respiration and sleep
- Mosquito-borne diseases and control
- Viral gastroenteritis research and epidemiology
- Liver Disease Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Immune Response and Inflammation
- Animal Virus Infections Studies
- Parasites and Host Interactions
- Long-Term Effects of COVID-19
- RNA Interference and Gene Delivery
- Sleep and Wakefulness Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Vector-borne infectious diseases
- Sepsis Diagnosis and Treatment
- COVID-19 epidemiological studies
- Hepatitis B Virus Studies
- Thermal Regulation in Medicine
- Immune Cell Function and Interaction
- Sexual function and dysfunction studies
- Axon Guidance and Neuronal Signaling
Universitat de Barcelona
2020-2024
Barcelona Institute for Global Health
2020-2024
University of Oxford
2023-2024
New York University
2010-2022
DMC University Laboratories
2020
Detroit Medical Center
2020
Icahn School of Medicine at Mount Sinai
2020
University of Connecticut
2007
Wayne State University
1974-1995
Veterans Health Administration
1995
Abstract Health care workers (HCW) are a high-risk population to acquire SARS-CoV-2 infection from patients or other fellow HCW. This study aims at estimating the seroprevalence against in random sample of HCW large hospital Spain. Of 578 participants recruited 28 March 9 April 2020, 54 (9.3%, 95% CI: 7.1–12.0) were seropositive for IgM and/or IgG IgA SARS-CoV-2. The cumulative prevalence (presence antibodies past current positive rRT-PCR) was 11.2% (65/578, 8.8–14.1). Among those with...
The major goal of this article is to provide an interpretative review the respiratory control system. First, we discuss two three basic elements system: sensors and controller (Fig. 1). Then, consider system as a whole integrated acute chronic responses various stimuli, including hypercapnia, hypoxemia, acid–base disturbances, acclimatization altitude response exercise. We have concentrated upon presenting material published within last six years.SensorsPeripheral ChemoreceptorsThe...
Unraveling the long-term kinetics of antibodies to SARS-CoV-2 and individual characteristics influencing it, including impact pre-existing human coronaviruses causing common cold (HCoVs), is essential understand protective immunity COVID-19 devise effective surveillance strategies. IgM, IgA IgG levels against six antigens nucleocapsid antigen four HCoV (229E, NL63, OC43 HKU1) were quantified by Luminex, antibody neutralization capacity was assessed flow cytometry, in a cohort health care...
Two doses of mRNA vaccination have shown >94% efficacy at preventing COVID-19 mostly in naïve adults, but it is not clear if the second dose needed to maximize effectiveness those previously exposed SARS-CoV-2 and what other factors affect responsiveness.We measured IgA, IgG IgM levels against spike (S) nucleocapsid (N) antigens from wild-type S Alpha, Beta Gamma variants concern, after BNT162b2 (Pfizer/BioNTech) or mRNA-1273 (Moderna) a cohort health care workers (N=578). Neutralizing...
At the COVID-19 spring 2020 pandemic peak in Spain, prevalence of SARS-CoV-2 infection a cohort 578 randomly selected health care workers (HCWs) from Hospital Clínic de Barcelona was 11.2%.A follow-up survey 1 month later (April-May 2020) measured by rRT-PCR and IgM, IgA, IgG to receptor-binding domain spike protein Luminex. Antibody kinetics, including subclasses, assessed until 3.At 1, serology 14.9% (84/565) seroprevalence 14.5% (82/565). We found 25 (5%) new infections 501 participants...
Abstract Background Health care workers (HCW) are a high-risk population to acquire SARS-CoV-2 infection from patients or other fellow HCW. At the same time, they can be contagious highly vulnerable individuals seeking health care. This study aims at estimating seroprevalence of antibodies against and associated factors in HCW large referral hospital Barcelona, Spain, one countries hardest hit by COVID-19 world. Methods From 28 March 9 April 2020, we recruited random sample 578 human...
A SARS-CoV-2 controlled human infection model (CHIM) has been successfully established in seronegative individuals using a dose of 1×10
Swine beta interferon (swIFN- β ) produced in HEK 293 cells infected with a recombinant, replication-defective human adenovirus 5 (Ad5) encoding the swIFN- gene was tested for antiviral activity against Porcine reproductive and respiratory syndrome virus (PRRSV). MARC-145 were incubated overnight dilutions of supernatant fluids from Ad5-swIFN- or an Ad5 control (Ad5-Blue). Treated PRRSV; Ad5-Blue supernatants developed cytopathic effects (CPE), whereas those showed no CPE. To confirm ,...
Abstract This study was done to determine whether a pathway of efferent axons in the carotid sinus nerve is necessary for phenomenon “efferent inhibition” (inhibition induced body chemoreceptors by electrical stimulation nerve). Our approach eliminate cats without destroying sensory axons. achieved cutting ipsilateral glossopharyngeal and vagus nerves central their ganglia and/or removing nodose superior cervical ganglia. In neurophysiological studies we found that response 10 days after...
Immunization with Plasmodium sporozoites can elicit high levels of sterile immunity, and neutralizing antibodies from protected hosts are known to target the repeat region circumsporozoite (CS) protein on parasite surface. CS-based subunit vaccines have been hampered by suboptimal immunogenicity requirement for strong adjuvants effective humoral immunity. Pathogen-associated molecular patterns (PAMPs) that signal through Toll-like receptors (TLRs) function as potent innate adaptive We...
It is known that alterations in insulin metabolism following injury and infection result depression of levels the development resistance. In order to further study during septic traumatic stress, we estimated production control (Group 1, n = 6), postoperative 2, 5), postoperative-septic 3, 8) human subjects by measuring 24-hour urinary C-peptide excretion. addition, basal peak glucose response a standard (0.5 gm/kg) intravenous stimulus were measured immediately thereafter determine if...