A5059772930- Bone and Dental Protein Studies
- HIV Research and Treatment
- Infectious Diseases and Tuberculosis
- Immune cells in cancer
- HIV-related health complications and treatments
- Tuberculosis Research and Epidemiology
- Adipose Tissue and Metabolism
- Bacterial Infections and Vaccines
- Neuroinflammation and Neurodegeneration Mechanisms
- Connective tissue disorders research
- Cardiovascular Disease and Adiposity
- Brain Tumor Detection and Classification
- HIV/AIDS oral health manifestations
- Biochemical effects in animals
- Adipokines, Inflammation, and Metabolic Diseases
- Supramolecular Self-Assembly in Materials
- Advanced Radiotherapy Techniques
- Migraine and Headache Studies
- Medical Imaging Techniques and Applications
- Nitric Oxide and Endothelin Effects
- Long-Term Effects of COVID-19
- Immune Response and Inflammation
- Ophthalmology and Eye Disorders
- COVID-19 Clinical Research Studies
- Hydrogen's biological and therapeutic effects
Johns Hopkins Medicine
2020-2023
Johns Hopkins University
2020-2023
Pediatrics and Genetics
2022
Ohio University
2017
Brigham and Women's Hospital
2016
Harvard University
2016
Tuberculous meningitis (TB meningitis) is the most severe form of tuberculosis (TB), requiring 12 months multidrug treatment for cure, and associated with high morbidity mortality. High-dose rifampin (35 mg/kg/d) safe improves bactericidal activity standard-dose (10 rifampin-containing TB regimen in pulmonary TB. However, there are conflicting clinical data regarding its benefit meningitis, where outcomes may also be intracerebral inflammation. We conducted cross-species studies mice...
Abstract Background Osteopontin (OPN) as a secreted signaling protein is dramatically induced in response to cellular injury and neurodegeneration. Microglial inflammatory responses the brain are tightly associated with neuropathologic hallmarks of neurodegenerative disease, but understanding molecular mechanisms remains several contexts poorly understood. Methods Micro-positron emission tomography (PET) neuroimaging using radioligands detect increased expression translocator (TSPO) receptor...
Abstract Background People with human immunodeficiency virus (HIV) have heightened incidence/risk of diastolic dysfunction and heart failure. Women HIV elevated cardiac fibrosis, plasma osteopontin (Opn) is correlated to pathology. Therefore, this study provides mechanistic insight into the relationship between fibrosis during infection. Methods Mouse embryonic fibroblasts (MEFs) modeled in vitro. Simian (SIV)-infected macaques or without antiretroviral therapy HIV-infected humanized mice...
The advent of Human Immunodeficiency Virus (HIV) antiretrovirals have reduced the severity HIV related neurological comorbidities but they nevertheless remain prevalent. Synaptic degeneration due to action several viral factors released from infected brain myeloid and glia cells inflammatory cytokines has been attributed manifestation a range cognitive behavioral deficits. contributions specific pro-inflammatory their interplay with in setting treatment persistence are incompletely...
Evidence suggesting that HIV pathogenesis differs by sex, a variable known to influence the extent and breadth of immune responses in health disease continues accumulate. Host factors promote or inhibit replication may do so way varies sex. Prior studies using cultured human macrophages demonstrated osteopontin (OPN)/secreted phosphoprotein-1 (SPP1) stimulates replication. To test whether OPN has same positive impact on virus at level tissues, we used humanized mice model low-level chronic...
An amendment to this paper has been published and can be accessed via the original article.
Abstract Background Pretomanid is used in combination with bedaquiline and linezolid (BPaL regimen) the treatment of multidrug-resistant tuberculosis (MDR-TB). However, penetration pretomanid privileged sites remain unknown. Antimicrobial pharmacokinetic (PK) parameters are traditionally derived from clinical samples (blood cerebrospinal fluid), which may not accurately represent intralesional tissue PK, affected by drug properties, vascular supply, barrier permeability, microenvironment....
Abstract Background Osteopontin (OPN) as a secreted signaling protein, is dramatically induced in response to cellular injury and neurodegeneration. Microglial inflammatory responses the brain are tightly associated with neuropathologic hallmarks of neurodegenerative disease, but understanding molecular mechanisms remains several contexts, poorly understood. Methods Positron emission tomography (PET) neuroimaging using radioligands detect increased expression translocator protein (TSPO)...
Abstract Background TB meningitis is the most severe form of tuberculosis (TB), associated with high morbidity and mortality. High-dose rifampin (35mg/kg/day) safe in adults substantially improves bactericidal activity standard regimen. However, there conflicting data regarding its benefit where outcomes may also be intracerebral inflammatory responses. Methods A novel mouse a validated rabbit model utilizing intracranial Mycobacterium infections were used for these studies (Fig. 1). Animals...