A5023196490- Environmental Toxicology and Ecotoxicology
- Pharmaceutical and Antibiotic Environmental Impacts
- Effects and risks of endocrine disrupting chemicals
- Epigenetics and DNA Methylation
- Nutritional Studies and Diet
- Aquaculture Nutrition and Growth
- Metabolomics and Mass Spectrometry Studies
- Birth, Development, and Health
- Computational Drug Discovery Methods
- Mercury impact and mitigation studies
- Neurobiology and Insect Physiology Research
- Calpain Protease Function and Regulation
- Insect Utilization and Effects
- Sodium Intake and Health
- CRISPR and Genetic Engineering
- Reproductive biology and impacts on aquatic species
- Marine Biology and Environmental Chemistry
- Helicobacter pylori-related gastroenterology studies
- Zebrafish Biomedical Research Applications
- Diet and metabolism studies
- Pesticide and Herbicide Environmental Studies
- Molecular Biology Techniques and Applications
- Metabolism, Diabetes, and Cancer
- Aquatic Invertebrate Ecology and Behavior
- Geochemistry and Elemental Analysis
Universidade do Porto
2016-2025
University of Trás-os-Montes and Alto Douro
2020-2024
Centro Interdisciplinar de Investigação Marinha e Ambiental
2019-2021
Institute of Marine Research
2019-2021
The antidiabetic drug Metformin (MET), one of the most prevalent pharmaceuticals in environment, is currently detected surface waters range ng/L to low μg/L. As current knowledge regarding long-term effects environmentally relevant concentrations MET nontarget organisms limited, present study aimed at investigating generational MET, ranging from 390 14 423 model organism Danio rerio (up 9 mpf), including on its nonexposed offspring (until 60 dpf). We integrate several apical end points,...
Simvastatin (SIM), a hypocholesterolaemic drug belonging to the statins group, is widely prescribed pharmaceutical for prevention of cardiovascular diseases. Several studies showed that lipophilic statins, as SIM, cross blood-brain barrier and interfere with energy metabolism central nervous system in humans mammalian models. In fish other aquatic organisms, effects SIM on brain are unknown, particularly following exposure low environmentally relevant concentrations. Therefore, present study...
The hypothesis that exposure to certain environmental chemicals during early life stages may disrupt reproduction across multiple non-exposed generations has significant implications for understanding disease etiology and adverse outcomes. We demonstrate here reproductive multi transgenerational effects, at environmentally relevant levels, of one the most prescribed human pharmaceuticals, simvastatin, in a keystone species, amphipod Gammarus locusta. findings major hazard risk assessment...
Abstract Assessing the impact that patterns of Na intake may have on gastric cancer will provide a more comprehensive estimation reduction as primary prevention approach. We aimed to estimate proportion cases are attributable above recommendation by WHO (≤2 g/d) throughout world in 2010, well expected values for 2030. Population fractions (PAF) were computed 187 countries, using intakes 1990 and 2010 estimates association between cancer, assuming time lag 20 years. Median PAF ranged from...
The adverse effects of certain environmental chemicals have been recently associated with the modulation epigenome. Although changes in epigenetic signature yet to be integrated into hazard and risk assessment, they are interesting candidates link exposures altered phenotypes, since these may passed across multiple non-exposed generations. Here, we addressed simvastatin (SIM), one most prescribed pharmaceuticals world, on regulation using amphipod Gammarus locusta as a proxy, support its...
The use of transcriptomics data brings new insights and works as a powerful tool to explore the molecular mode action (MoA) transgenerational inheritance effects contaminants emerging concern. Therefore, in this dataset, we present transcriptomic environmentally relevant simvastatin levels, one most prescribed human pharmaceuticals, keystone amphipod species Gammarus locusta. In summary, G. locusta juveniles were maintained under exposure up adulthood (exposed group - F0E) offspring F0E...
ADVERTISEMENT RETURN TO ISSUEPREVViewpointNEXTIs the Environmental Risk of Metformin Underestimated?Unax Lertxundi*Unax LertxundiBioaraba Health Research Institute, Osakidetza Basque Service, Araba Mental Network, Psychiatric Hospital, Pharmacy c/Alava 43, 01006 Vitoria-Gasteiz, Alava, Spain*+34 945 00 65 33, +34 87, [email protected]More by Unax LertxundiView Biographyhttps://orcid.org/0000-0002-9575-1602, Saioa Domingo-EchaburuSaioa Domingo-EchaburuOsakidetza Debagoiena Integrated...
The nonsteroidal anti-inflammatory drug naproxen (NPX) is among the most consumed pharmaceuticals worldwide, being detected in surface waters within ng to μg/L range. Considering limited chronic ecotoxicity data available for NPX aquatic ecosystems, present study aimed at evaluating its impact model organism
Abstract Simvastatin (SIM), a hypocholesterolaemic compound, is among the most prescribed pharmaceuticals for cardiovascular disease prevention worldwide. Several studies have shown that acute exposure to SIM able produce multiple adverse effects in aquatic organisms. However, uncertainties still remain regarding chronic of ecosystems. Therefore, present study aimed investigate model freshwater teleost zebrafish ( Danio rerio ) following (90 days) environmentally relevant concentrations...
Abstract The adverse effects of certain environmental chemicals have been recently associated with epigenome’s modulation. Although the changes in epigenetic signature are still not integrated into hazard and risk assessment, they interesting candidates for linking exposures to altered phenotypes given that these may be passed across multiple non-exposed generations. Here, we addressed simvastatin (SIM), one most prescribed human pharmaceuticals, regulators amphipod Gammarus locusta , as a...
Abstract Metformin (MET) is an anti-diabetic pharmaceutical with a large-scale consumption, which increasingly detected in surface waters. However, current knowledge on the generational effects of MET exposure metabolism non-target organisms limited. The present study aimed at investigating model freshwater teleost Danio rerio , following (from egg up to 9 months exposure) environmentally relevant concentrations ranging from 361 ng/L 13 000 ng/L. Biochemical markers were used determine...