A5049675090- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Cancer-related Molecular Pathways
- CAR-T cell therapy research
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Cancer Treatment and Pharmacology
- Frailty in Older Adults
- Eicosanoids and Hypertension Pharmacology
- Colorectal Cancer Treatments and Studies
- Cancer Research and Treatments
- Advanced Breast Cancer Therapies
- Cancer-related cognitive impairment studies
- Cancer, Hypoxia, and Metabolism
- Occupational and environmental lung diseases
- Immune Cell Function and Interaction
- Nutrition and Health in Aging
University of Minnesota System
2025
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2020-2022
Azienda Ospedaliero Universitaria Maggiore della Carita
2021
<title>Abstract</title> CIC::DUX4 sarcoma (CDS) is a highly aggressive malignancy with limited therapeutic options. Here, we present doxycycline-inducible chimeric mouse model and cancer line derived from it, imChCDS, that faithfully recapitulates the molecular, histological, immunological features of human CDS. We demonstrate expression alone sufficient to drive tumorigenesis in permissive lineages soft connective tissues. The imChCDS cell retains transcriptional footprint its mesenchymal...
Abstract Background Age is considered as one of the most important risk-factor for many types solid and hematological cancers, their incidence increases with age in parallel to ever-growing elderly population. Moreover, cancer constantly increasing a consequence increase life expectancy that favors process cellular senescence. Geriatric assessment has been increasingly recognized predictive prognostic instrument detect frailty older adults cancer. In particular, G8 score simple reproducible...
e15263 Background: The introduction of immune check-point inhibitors (ICIs) in the treatment a broad range tumor types has led to significant and clinically meaningful improvement overall survival (OS) advanced disease stages. However, efficacy these agents is not consistent across trials routine practice. role PD-L1 expression as tumour-agnostic predictive correlate response ICIs remains unclear. We performed pooled analysis PD-1/PD-L1-targeted ICI regimens compared standard care (SoC)...
Abstract Background: Increasing evidence suggests a link between T-cell senescence and tumour prognosis. In particular, high levels of circulating senescent T-lymphocytes have been also correlated with worse response to anti-cancer treatments. this perspective, therapeutic approach aimed at clearance restoring is regarded as an innovative strategy in cancer treatment currently under investigation pre-clinical clinical models. The purpose the present study characterize impact predictive...