A5000859864- Cutaneous Melanoma Detection and Management
- Optical Coherence Tomography Applications
- Photoacoustic and Ultrasonic Imaging
- Cancer and Skin Lesions
- Nonmelanoma Skin Cancer Studies
- Autoimmune Bullous Skin Diseases
- Sarcoma Diagnosis and Treatment
- Genetic and rare skin diseases.
- Skin and Cellular Biology Research
- Drug-Induced Adverse Reactions
- Cutaneous lymphoproliferative disorders research
- Advanced Fluorescence Microscopy Techniques
- Eosinophilic Disorders and Syndromes
- Vascular Tumors and Angiosarcomas
- Nail Diseases and Treatments
- Skin Protection and Aging
- Soft tissue tumor case studies
- Dermatological and Skeletal Disorders
- Soft tissue tumors and treatment
- Hair Growth and Disorders
- melanin and skin pigmentation
- Microbial Inactivation Methods
- Infectious Diseases and Mycology
- Urticaria and Related Conditions
- Melanoma and MAPK Pathways
Wayne State University
2016-2025
Wayne State College
2017-2024
Michigan United
2024
Pinkus Dermatopathology Laboratory
2007-2021
The Barbara Ann Karmanos Cancer Institute
2020
AC Camargo Hospital
2019
University Medical Center
2016-2017
National Institutes of Health
2014
Memorial Sloan Kettering Cancer Center
2014
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2014
Abstract The current gold standard for clinical diagnosis of melanoma is excisional biopsy and histopathologic analysis. Approximately 15–30 benign lesions are biopsied to diagnose each melanoma. In addition, biopsies invasive result in pain, anxiety, scarring, disfigurement patients, which can add additional burden the health care system. Among several imaging techniques developed enhance diagnosis, optical coherence tomography (OCT), with its high-resolution intermediate penetration depth,...
Currently, diagnosis of skin diseases is based primarily on visual pattern recognition skills and expertise the physician observing lesion. Even though dermatologists are trained to recognize patterns morphology, it still a subjective assessment. Tools for automated can provide objective information support clinical decision-making. Noninvasive imaging techniques complementary clinician. In recent years, optical coherence tomography has become powerful technique. According specific...
The marked increase in the incidence of melanoma coupled with rapid drop survival rate after metastasis has promoted investigation into improved diagnostic methods for melanoma. High-frequency ultrasound (US), optical coherence tomography (OCT), and photoacoustic imaging (PAI) are three potential modalities that can assist a dermatologist by providing extra information beyond dermoscopic features. In this study, we imaged swine model spontaneous using these compared images nearby healthy...
Identifying the location of dermal epidermal junction (DEJ) in skin images is essential several clinical applications dermatology such as thickness determination healthy versus unhealthy skins, basal cell carcinoma. Optical coherence tomography (OCT) facilitates visual detection DEJ vivo. However, due to granular texture speckle and a low contrast between dermis epidermis, border method required for localization. Current algorithms work well skins with visible differentiable layer but not...
TikTok is the fifth most popular social media platform worldwide, with 1.04 billion active monthly users [1]. This app allows to share videos content ranging from naturopathic remedies evidence-based healthcare information. Given that approximately 25% of U.S. are under age 18, it necessary evaluate quality dermatological information on assess its impact a highly impressionable demographic [2]. Retinol has many benefits in treatment multiple dermatoses, including acne vulgaris, and rhytides...
EpCam is a transmembrane epithelial adhesion molecule present on all non-squamous cells. It often overexpressed in certain carcinomas, such as breast and colon, dermatology, eg, basal cell carcinoma (BCC). Various monoclonal antibodies have been used to detect EpCam, including BerEP4 specific antigen. We compared anti-EpCam clones, BerEP4, antigen clone VU-1D9. One hundred twelve lesions were stained with both antibodies. All carcinomas uniformly strongly positive Diffuse staining was also...
Objective: To evaluate the feasibility of high-frequency ultrasound and elastography (USE) in discriminating benign from malignant skin lesions a prospective cohort study to introduce use "strain ratio" for evaluation lesions. Methods: A commercial system with 14-MHz transducer was used visualize requiring biopsy on clinical evaluation. Anatomic USE imaging performed using 2- 4-mm gel stand-off pads. region interest manually selected over area each lesion lowest strain. The concept strain...
Abstract Background Skin cancer represents the most prevalent type of in United States. Excision these lesions can leave significant scarring, and a delay diagnosis malignant melanoma could result metastasis or death. Therefore, developing technology criteria to accurately diagnose cancers is particular importance medical community. While biopsy lead scarring infections, dermoscopy confocal microscopy offer noninvasive imaging methods but are also limited their ability determine tumor depth...
Optical coherence tomography (OCT) has become a popular modality in the dermatology discipline due to its moderate resolution and penetration depth. OCT images, however, contain grainy pattern called speckle. To date, variety of filtering techniques have been introduced reduce speckle images. However, further improvement is required edge smoothing deterioration small structures images after despeckling. In this manuscript, we present novel cluster-based reduction framework (CSRF) that...
Different immunohistochemical stains are used in dermatopathology to stain melanocytes and diagnose benign malignant melanocytic lesions.SOX-10, HMB-45, Melan-A were assess 32 biopsy specimens with a histologic diagnosis of lentigo. The total number stained each was counted an average count obtained from two readings.Analysis the data revealed significant difference staining between these three immunostains (p=0.0010, ANOVA). SOX-10 0.195 more than HMB-45 (p=0.0026). Similarly, (p=0.0011)....
The cutaneous lesions in chronic lupoid leishmaniasis resemble those of lupus vulgaris, both clinically and histologically. differential diagnosis is difficult may depend on the detection a few Leishmania amastigotes histologic sections, growth promastigotes cultures, or identification by other techniques. Polymerase chain reaction was used to detect amastigote DNA tissue samples obtained from 65 patients with leismaniasis, results were confirmed Southern blot analysis.The findings...
We reviewed the clinical, histologic, and immunofluorescence features of 20 patients with pemphigus neoplasia compared them will a control group 17 without neoplasia. Patients were divided according to findings into those paraneoplastic syndrome (12 patients) classic vulgaris or foliaceus (8 patients). The histologic in included acantholysis, interface dermatitis, spongiosis, satellite keratinocyte necrosis. Histologic 8 acantholysis spongiosis. Direct both showed IgG staining cell‐surface...
Granulocyte-monocyte colony-stimulating factor (GMCSF) is a hematopoietic growth that stimulates the proliferation and differentiation of neutrophils, eosinophils, monocytes. We reviewed cutaneous reactions developed in 26 patients who received GMCSF as part chemotherapeutic protocol.Fourteen immediate localized angioedematous at subcutaneous injection site, 21 generalized reactions. Four biopsy specimens were obtained from three had erythrodermic All showed perivascular periadnexal...
Optical coherence tomography (OCT) of skin delivers three-dimensional images tissue microstructures. Although OCT imaging offers a promising high-resolution modality, suffer from some artifacts that lead to misinterpretation structures. Therefore, an overview methods mitigate in the is paramount importance. Speckle, intensity decay, and blurring are three major images. Speckle due low coherent light source used configuration OCT. Intensity decay deterioration with respect depth, consequence...