A5021542393- Stroke Rehabilitation and Recovery
- Cerebral Palsy and Movement Disorders
- Cancer Genomics and Diagnostics
- Action Observation and Synchronization
- Prosthetics and Rehabilitation Robotics
- EEG and Brain-Computer Interfaces
- CAR-T cell therapy research
- Muscle activation and electromyography studies
- Telemedicine and Telehealth Implementation
- PARP inhibition in cancer therapy
- Cancer Immunotherapy and Biomarkers
- Hypothalamic control of reproductive hormones
- Molecular Biology Techniques and Applications
- Reproductive biology and impacts on aquatic species
- Bone Metabolism and Diseases
- Transcranial Magnetic Stimulation Studies
- Blood Coagulation and Thrombosis Mechanisms
- Advanced Biosensing Techniques and Applications
- Brain Metastases and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Employment and Welfare Studies
- Protease and Inhibitor Mechanisms
- Antioxidant Activity and Oxidative Stress
- Lung Cancer Treatments and Mutations
- Neurobiology of Language and Bilingualism
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2024
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2018-2024
Vita-Salute San Raffaele University
2023-2024
IRCCS Ospedale San Raffaele
2018-2023
Institut Gustave Roussy
2022-2023
University of Genoa
1999-2005
Background Action Observation Therapy (AOT) leverages mirror neuron system (MNS) activation to enhance neuroplasticity and motor recovery after stroke. While AOT has demonstrated positive effects, the neural mechanisms underlying its efficacy, particularly regarding task type network engagement, remain unclear. This observational cohort study investigates cortical during observation of goal-oriented Activities Daily Living (ADLs) in healthy individuals chronic stroke patients. Methods Twenty...
Abstract During osteogenesis, in vitro, of tibial-derived rat osteoblasts (ROB) and derived clones, changes occur the interactions mature with endogenous extracellular matrix (ECM) these culminate formation tridimensional nodules, which become sites mineral deposition. We investigated if might be mediated by remodeling ECM, we focused our study on neutral metalloproteinases (MMPs), known agents remodeling, their tissue inhibitors (TIMPs). report that during vitro differentiation, express...
During the last years, significant increase in number of patients need rehabilitation has generated an unsustainable economic impact on healthcare systems, implying a reduction therapeutic supervision and support for each patient. To address this problem, paper proposes telerehabilitation system based serious games in-cloud data analytics services, accordance with Industry 4.0 design principles regarding modularity, service orientation, decentralization, virtualization, real-time capability....
Pervasive health technologies can increase the effectiveness of personal monitoring and training, but more user studies are necessary to understand interest for these technologies, how they should be designed implemented. In present study, we evaluated eWALL, a user-centered pervasive technology consisting platform that monitors users’ physical cognitive behavior, providing feedback motivation via an easy-to-use, touch-based interface. The eWALL was placed one month in home 48 subjects with...
Background: Overground Robot-Assisted Gait Training (o-RAGT) appears to be a promising stroke rehabilitation in terms of clinical outcomes. The literature on surface ElectroMyoGraphy (sEMG) assessment o-RAGT is limited. This paper aimed assess muscle activation patterns with sEMG subjects subacute post after training and conventional therapy. Methods: An observational preliminary study was carried out who received 15 sessions (5 sessions/week; 60 min) combination were assessed both...
In rehabilitation, the upper limb function is generally assessed using clinical scales and functional motor tests. Although Box Block Test (BBT) commonly used for its simplicity ease of execution, it does not provide a quantitative measure movement quality. This study proposes integration an ecological Inertial Measurement Units (IMUs) system analysis body kinematics during execution targeted version BBT, by able-bodied persons with subjects Parkinson’s disease (PD). Joint angle parameters...
Objective: To evaluate the psychological state of healthcare workers (HCWs) in field rehabilitation during COVID-19 pandemic. Methods: Cross-sectional observational study. Sample 334 HCWs including: nurses, medical doctors, therapists, scientists, and clerical working at IRCCS San Raffaele Roma hospital second wave Anonymous web-based questionnaire included 14-item Resilience Scale, Brief-COPE, Hospital Anxiety Depression Fear Scale. Occupational sociodemographic characteristics. Results:...
Background: The limitation to the use of ElectroMyoGraphy (sEMG) in rehabilitation services is contrast with its potential diagnostic capacity for rational planning and monitoring treatments, especially overground Robot-Assisted Gait Training (o-RAGT). Objective: To assess barriers implementation a sEMG-based assessment protocol clinical context evaluating effects o-RAGT subacute stroke patients. Methods: An observational study was conducted hospital. primary outcome success rate assessment....
The Action Observation Therapy (AOT) is a well-established post-stroke rehabilitation treatment based on the theoretical framework of Mirror Neuron System (MNS) activation. However, AOT protocols are still heterogeneous in terms video contents observed actions.The aim this study was to analyze electroencephalographic (EEG) recordings stroke patients during observation different videos task-specific upper limb movements, and define which category actions can elicit stronger cortical...
(1) Background: In neurorehabilitation, Wearable Powered Exoskeletons (WPEs) enable intensive gait training even in individuals who are unable to maintain an upright position. The importance of WPEs is not only related their impact on walking recovery, but also the possibility using them as assistive technology; however, WPE-assisted community ambulation has rarely been studied terms performance real-life scenarios. (2) Methods: This study proposes integration Inertial Measurement Unit (IMU)...
By stating "All people, everywhere, deserve the right care, in their community," <xref ref-type="bibr" rid="ref21" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">[21]</xref> . World Health Organization sets, an exhortative way, fundamental assumption for primary health care. Under these premises, we developed augmented and extended approach to a home-rehabilitation system provide intensive care chronic stroke patients with aphasia. The proposes...
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<title>Abstract</title> In recent years, the fusion of medical and computer science domains has gained significant traction in scientific research landscape. Progress both fields enabled generation a vast amount data used for making predictions identifying interesting clusters pathways. The Machine Learning model's application domain is one most compelling challenging topics to explore, bridging gap between Artificial Intelligence (AI). healthcare. combination AI information offers...
The Gustave Roussy Immune (GRIm)-Score considers neutrophil-to-lymphocyte ratio (NLR), serum albumin concentration and lactate dehydrogenase (LDH) its prognostic value has been investigated in patients treated with immune check-point blockers (ICBs). According to their GRIm-score, can be classified as low risk (GRIm-score 0 or 1) high (GRIM-score 2 3). We aimed determine whether it could used a tool for phase I clinical trials bispecific CD3 T cell engagers. A retrospective analysis on...
In the last few years, new noninvasive strategies have emerged as rehabilitative treatments for patients with stroke. Action observation treatment (AOT) is a rehabilitation approach based on properties of mirror neuron system positive impact modifying cortical activation patterns and improving upper limb kinematics. AOT involves dynamic process observing purposeful actions intention imitating then practicing those actions. recent several clinical studies suggested effectiveness in stroke to...