A5087102050- COVID-19 epidemiological studies
- Viral Infections and Outbreaks Research
- Viral Infections and Vectors
- Immune responses and vaccinations
Broad Institute
2020
Center for Systems Biology
2020
Harvard University
2020
Ebola virus (EBOV) causes epidemics with high mortality yet remains understudied due to the challenge of experimentation in high-containment and outbreak settings. Here, we used single-cell transcriptomics CyTOF-based protein quantification characterize peripheral immune cells during EBOV infection rhesus monkeys. We obtained 100,000 transcriptomes 15,000,000 profiles, finding that immature, proliferative monocyte-lineage reduced antigen-presentation capacity replace conventional monocyte...
Summary Ebola virus (EBOV) causes epidemics with high case fatality rates, yet remains understudied due to the challenge of experimentation in high-containment and outbreak settings. To better understand EBOV infection vivo , we used single-cell transcriptomics CyTOF-based protein quantification characterize peripheral immune cell activity during rhesus monkeys. We obtained 100,000 transcriptomes 15,000,000 profiles, providing insight into pathogenesis. find that immature, proliferative...