A5055107426- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Functional Brain Connectivity Studies
- Spectral Theory in Mathematical Physics
- Numerical methods in inverse problems
- Advanced Computational Techniques and Applications
- Oxidative Organic Chemistry Reactions
- Synthesis of Tetrazole Derivatives
- melanin and skin pigmentation
- Probiotics and Fermented Foods
- Antibiotic Resistance in Bacteria
- Chemical Synthesis and Reactions
- Medicinal Plants and Neuroprotection
- Fractional Differential Equations Solutions
- Synthesis and biological activity
- Obsessive-Compulsive Spectrum Disorders
- MRI in cancer diagnosis
- Catalytic C–H Functionalization Methods
- Immunotherapy and Immune Responses
- Cytokine Signaling Pathways and Interactions
- Click Chemistry and Applications
- Sulfur-Based Synthesis Techniques
- Vibrio bacteria research studies
- Service-Oriented Architecture and Web Services
- Simulation and Modeling Applications
Hangzhou Seventh Peoples Hospital
2020-2025
Zhejiang University
2007-2025
Hangzhou Normal University
2021-2025
China National Research Institute of Food and Fermentation
2024-2025
Beijing Forestry University
2018-2024
Deleted Institution
2019-2024
Donghua University
2024
Union Hospital
2024
Huazhong University of Science and Technology
2024
Huashan Hospital
2024
Abstract This study aimed to design and synthesize active hybrids of β ‐elemene nitric oxide (NO) donor pharmacophore as potential agents for treating leukemia. Derivatives reported herein exerted better inhibitory effects against human chronic myeloid leukemia K562 cells compared (IC 50 > 100 μM). The most potent compound 18f showed an IC value 0.53 μM cells, well a high NO release level in vitro. In the xenograft tumor mice model, effectively inhibited growth tumor, with significant...
Lycium barbarum is a boxthorn that produces the goji berries. The aim of current study was to evaluate proliferative effect L. polysaccharides (LBP) on probiotics. LBP extracted from berries and its monosaccharide composition characterized by gas chromatography (GC). extract contained arabinose, rhamnose, xylose, mannose, galactose, glucose. obviously promoted proliferation lactic acid bacteria (LAB) strains, especially Bifidobacterium longum subsp. infantis Bi-26 Lactobacillus acidophilus...
Background The key pathophysiological mechanism of executive dysfunction in patients with bipolar disorder type I (BD-I) is still unclear. Previous studies have demonstrated that it may be related to the disbalance sensory motor network (SMN). Objective This study was designed explore aberrant functional connectivity (FC) SMN BD-I and its potential associations dysfunction. Methods Eighteen 20 healthy controls (HCs) underwent resting-state fMRI scans. intranetwork internetwork connectivities...
Artificial intelligence (AI) de novo molecular generation is a highly promising strategy in the drug discovery, with deep reinforcement learning (RL) models emerging as powerful tools. This study introduces fragment-by-fragment growth RL forward and optimization based on low activity lead compound. process integrates fragment growth-based reaction templates, while target docking drug-likeness prediction were simultaneously performed. comprehensive approach considers similarity, internal...
MAO-B leads to an increase in the levels of hydrogen peroxide and oxidative free radicals, which contribute aetiology AD. Thus, both iron ion chelators inhibitors can be used treat Taking coumarin derivatives hydroxypyridinones as lead compounds, a series dual-target hybrids were designed synthesised by Click Chemistry. The compounds biologically evaluated for their chelating inhibitory activity. Most displayed excellent activity moderate good anti-MAO-B Compounds 27b 27j exhibited most...