Alla Yur'evna Tokmakova

ORCID: 0000-0003-2474-9924
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About
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Research Areas
  • Diabetic Foot Ulcer Assessment and Management
  • Neurological Disorders and Treatments
  • Wound Healing and Treatments
  • Skin Diseases and Diabetes
  • Diabetes Treatment and Management
  • Diabetes Management and Research
  • Peripheral Artery Disease Management
  • Myofascial pain diagnosis and treatment
  • Diabetes and associated disorders
  • Pain Management and Treatment
  • Pressure Ulcer Prevention and Management
  • Hyperglycemia and glycemic control in critically ill and hospitalized patients
  • Botulinum Toxin and Related Neurological Disorders
  • Neurological and metabolic disorders
  • Systemic Sclerosis and Related Diseases
  • Pain Mechanisms and Treatments
  • Mesenchymal stem cell research
  • Advanced Glycation End Products research
  • Tendon Structure and Treatment
  • Healthcare Systems and Public Health
  • Parathyroid Disorders and Treatments
  • Bone and Joint Diseases
  • Autoimmune Bullous Skin Diseases
  • Laser Applications in Dentistry and Medicine
  • Orthopedic Infections and Treatments

Endocrinology Research Center
2016-2025

Ministry of Health of the Russian Federation
2015-2023

Sechenov University
2014

Dear Colleagues! We are glad to present the 9th Edition (revised) of Standards Diabetes Care. These evidence-based guidelines were designed standardize and facilitate diabetes care in all regions Russian Federation. The updated on regular basis incorporate new data relevant recommendations from national international clinical societies, including World Health Organization Guidelines (WHO, 2011, 2013), International Federation (IDF, 2012, American Association (ADA, 2018, 2019), Clinical...

10.14341/dm221s1 article EN cc-by-nc-nd Diabetes Mellitus 2019-12-03

Dear Colleagues! We are glad to present the8th Editionof Standards of Diabetes Care. These evidence-based guidelines were designed standardize and facilitate diabetes care in all regions the Russian Federation. The updated on regular basis incorporate new data relevant recommendations from national international clinical societies, including World Health Organization Guidelines (WHO, 2011, 2013), International Federation (IDF, 2012, American Association (ADA, 2017), Clinical Endocrinologists...

10.14341/dm20171s8 article EN cc-by-nc-nd Diabetes Mellitus 2017-03-01

Dear Colleagues! We are glad to present the 10th Edition (revised) of Standards Specialized Diabetes Care. These evidence-based guidelines were designed standardize and facilitate diabetes care in all regions Russian Federation. The updated on regular basis incorporate new data relevant recommendations from national international clinical societies, including World Health Organization Guidelines (WHO, 2011, 2013), International Federation (IDF, 2012, European Association for Study (EASD...

10.14341/dm12802 article EN Diabetes Mellitus 2022-08-31

Dear Colleagues! We are glad to present the 11 th Edition of Standards Specialized Diabetes Care. These evidence-based guidelines were designed standardize and facilitate diabetes care in all regions Russian Federation. The updated on regular basis incorporate new data relevant recommendations from national international clinical societies, including World Health Organization Guidelines (WHO), International Federation (IDF), European Association for Study (EASD), American (ADA), Clinical...

10.14341/dm13042 article EN cc-by-nc-nd Diabetes Mellitus 2023-06-15

Москва 2020 СОДЕРЖАНИЕ СПИСОК СОКРАЩЕНИЙ ТЕРМИНЫ И ОПРЕДЕЛЕНИЯ 7.5.1 Особенности артериальной гипертензии при сахарном диабете 2 типа 7.5.2Особенности ишемической болезни сердца 7.5.3Особенности хронической сердечной недостаточности 7.5.4Особенности заболеваний артерий нижних конечностей 7.5.5 критической ишемии 7.6 ОСОБЕННОСТИ ЛЕЧЕНИЯ САХАРНОГО ДИАБЕТА ТИПА ПРИ БЕРЕМЕННОСТИ 7.7 В ПОЖИЛОМ ВОЗРАСТЕ ЛИТЕРАТУРЫ ПРИЛОЖЕНИЯ Аналоги инсулина -форма инсулина, в которой произведены некоторые...

10.14341/dm12507 article RU cc-by-nc-nd Diabetes Mellitus 2020-06-22

Lesions of the lower extremities in diabetes mellitus are a complex and urgent problem modern medicine. The high prevalence mellitus, significant difficulties timely diagnosis, differential diagnosis choice therapeutic tactics to preserve supporting function limb determine managing diabetic patients. Over past decades, changes have occurred structure specialized medical care for foot patients which has significantly reduced number amputations, improved quality life expectancy article...

10.14341/dm13245 article EN cc-by-nc-nd Diabetes Mellitus 2025-01-27

Dear Colleagues!. We are glad to present the 6th Edition of Standards Diabetes Care. These evidence-based guidelines were designed standardize and facilitate diabetes care in all regions Russian Federation. The updated on regular basis incorporate new data relevant recommendations from national international clinical societies, including World Health Organization Guidelines (WHO, 2011), International Federation (IDF, American Association (ADA, 2013), Clinical Endocrinologists (AACE, 2009),...

10.14341/dm20131s1-121 article EN cc-by-nc-nd Diabetes Mellitus 2013-06-30

Сахарный диабет (СД) ? системное заболевание обмена веществ, которое приняло пандемический характер распространения, что побудило Организацию Объединенных Наций (ООН) в декабре 2006 г. принять резолюцию, призывающую ?создавать национальные программы по предупреждению, лечению и профилактике СД его осложнений включать их состав государственных программ здравоохранению?. За последние 30 лет темпам прироста заболеваемости опередил такие инфекционные заболевания, как туберкулез ВИЧ. Численность...

10.14341/2072-0351-5612 article RU cc-by-nc-nd Diabetes Mellitus 2011-09-15

The guideline presents modern classification, diagnostic algorithms and protocols of complex treatment various forms diabetic foot syndrome. recommendations are intended for use by a wide range professionals involved in the patients with this pathology.

10.17650/2408-9613-2015-2-3-63-83 article EN cc-by Wounds and wound infections The prof B M Kostyuchenok journal 2015-12-19

We are glad to present the 7th Edition of Standards Diabetes Care.These evidence-based guidelines were designed standardize and facilitate diabetes care in all regions Russian Federation.The updated on regular basis incorporate new data relevant recommendations from national international clinical societies, including World Health Organization Guidelines (WHO, 2011, 2013), International Federation (IDF, 2012, American Association (ADA, 2015), Clinical Endocrinologists (AACE, Society for...

10.14341/dm7078 article EN cc-by-nc-nd Diabetes Mellitus 2015-03-02

Dear Colleagues! We are glad to present the 9th Edition (revised) of Standards Diabetes Care. These evidence-based guidelines were designed standardize and facilitate diabetes care in all regions Russian Federation. The updated on regular basis incorporate new data relevant recommendations from national international clinical societies, including World Health Organization Guidelines (WHO, 2011, 2013), International Federation (IDF, 2012, American Association (ADA, 2018, 2019), Clinical...

10.14341/dm12211 article EN cc-by-nc-nd Diabetes Mellitus 2019-12-03

Diabetic peripheral neuropathy is a common chronic complication of diabetes mellitus, significantly impairing well-being, quality life and functioning patients. The prevalence diabetic in the Russian Federation ranges from 0.1% to 67.2% type 1 0.1 42.4% 2 mellitus. However, based on large-scale epidemiological studies, true much higher (50 70%), with its painful variant occurring 16% 30% Despite fact that remains most diagnosis therapy leave be desired. To optimize diagnostic treatment...

10.14341/dm9625 article EN cc-by-nc-nd Diabetes Mellitus 2019-09-12

Diabetes mellitus is one of the most common chronic diseases in world. According to International Federation (IDF), by 2035 number diabetes patients will reach 592 million people. Various disorders structure and function soft tissues skeleton lower extremities reason that seek medical care. The paper presents modern concept pathogenesis, diagnosis, therapeutic prevention tactics used specialized endocrinological surgical clinics.

10.14341/omet2017141-47 article EN cc-by-nc-nd Obesity and metabolism 2017-06-13

Общественная организация «Российская ассоциация эндокринологов» КЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИ САХАРНЫЙ ДИАБЕТ 1 ТИПА ТЕРМИНЫ И ОПРЕДЕЛЕНИЯ Аналоги инсулина -форма инсулина, в которой произведены некоторые изменения молекуле человеческого инсулина.Аналог действует так же, как инсулин, но с фармакокинетическими/фармакодинамическими различиями, которые могут иметь преимущества

10.14341/dm12505 article RU cc-by-nc-nd Diabetes Mellitus 2020-06-22

Delayed wound healing is characteristic of a glycemic disorder and often results in trophic ulcer formation, ? process still poorly understood but likely multifaceted. Current review addresses latest reports from cellular molecular studies soft tissue regeneration patients with diabetes mellitus.

10.14341/dm2014157-62 article EN cc-by-nc-nd Diabetes Mellitus 2014-03-29

Current trends in conservative therapy of chronic wounds associated with diabetes mellitus are discussed along results original studies aimedto assess efficacy different methods for unloading the affected leg patients neuropathic form diabetic foot syndrome and diabeticnephropathy. Effects collagen-containing dressings on wound-related factors (matrix metalloproteinases 2 9, collagenolytic activity) andwound epithelization rate described.

10.14341/2072-0351-6060 article EN cc-by-nc-nd Diabetes Mellitus 2010-12-15

Peripheral artery diseases (PAD) are most serious diabetic complications responsible for the high risk of amputation lower extremities. The occurrenceof PAD in patients is much higher than subjects with undisturbed carbohydrate metabolism. frequentlyan asymptomatic condition affecting distal portions arterial segments and associated pronounced mediacalcinosis. Standard diagnostic proceduresfor screening lesions must be supplemented by non-invasive visualization measurement transcutaneous...

10.14341/2072-0351-6253 article EN cc-by-nc-nd Diabetes Mellitus 2011-03-15

This paper is focused on the main aspects of pathogenesis diabetic osteoarthropathy (DOAP) underlain by motor and sensory neuropathies, injuries(including microfractures joint disintegration), inflammation accompanied enhanced cytokine expression. The role osteopenia andbone resorption-formation decoupling at different stages DOAP discussed. Modern methods treatment are considered with special referenceto immobilization, drug therapy, surgical orthopedic care

10.14341/2072-0351-6061 article EN cc-by-nc-nd Diabetes Mellitus 2010-12-15

The extent of damage to the nervous, vascular and microcirculatory systems in diabetic patients determine regulation physiological events that lead formation chronic wounds, reduction patient quality life increase financial value medical care. Successful repair is impossible without successive phases inflammation, proliferation wound healing. Keratinocytes are major cellular barrier components epidermis. These cells play an important role repair, as suggested by recent research, with many...

10.14341/dm8131 article EN cc-by-nc-nd Diabetes Mellitus 2016-12-31

Diabetic cardiovascular autonomic neuropathy (DCAN) is a diabetic complication characterised by early dissemination of sympathetic and parasympathetic, small-fibre neuronal degeneration. DCAN the most dangerous insidious that influences clinical course mortality rate diabetes; however, it often underestimated not recognised practitioners. Medical history physical examination are sufficient for diagnosing DCAN. Laboratory diagnosis instrumental methods used to evaluate time-consuming always...

10.14341/8156 article EN cc-by-nc-nd Diabetes Mellitus 2016-12-22

Цели. Оценка эффективности программы обучения для больных СД2 на инсулинотерапии по ряду показателей (HbA1c, масса тела, частота гипогликемий, показатели поведения, связанного с заболеванием). Сравнение групповой и индивидуальной форм обучения. Материалы методы. В исследование включались больные верифицированным диагнозом СД2, получающие терапию инсулином не менее 3 месяцев, изъявившие согласие обследование, имеющие терминальных стадий осложнений СД, тяжелых сопутствующих заболеваний,...

10.14341/2072-0351-5595 article RU cc-by-nc-nd Diabetes Mellitus 2008-12-15

Chronic wound in patients with diabetes mellitus (DM) is one of the most urgent problems modern diabetology and surgery. Numberof suffering from different types chronic wounds follows increase DM incidence. Vacuum therapy a novel perspectivemethod topical treatment for non-healing various etiology. Current review addresses experimental clinicalevidence this method.

10.14341/2072-0351-6085 article EN cc-by-nc-nd Diabetes Mellitus 2012-09-15

Aim. To evaluate the morphological and immunohistochemical features of granulation tissue formation in patients with diabetic foot syndrome.Materials methods. We analysed histological (light microscopy) (CD31, CD68, osteopontin, MMP-9 TIMP-1) repair processes diabetes mellitus. The study involved 63 syndrome after surgical debridement.Results. found severe intercellular oedema, poorly organised extracellular matrix, small amounts fibroblast-like cells expressed inflammatory infiltration,...

10.14341/dm7587 article EN cc-by-nc-nd Diabetes Mellitus 2015-10-15

Данные о распространенности ДОАП среди больных СД в литературе разноречивы и варьируют преде- лах от 0,1 до 55%. Как правило, диагностируется у пациентов с длитель- ностью течения более 15 лет неудовлетворительным контролем заболевания. Манифестация заболевания часто захватывает суставы одной стопы. Однако 5,9?39,3% случаев встречаются билатеральные поражения. частоте гнойных осложнений, ампутаций, а также долгосрочных результатов реконструктивных оперативных вмешательств данной категории...

10.14341/2072-0351-5425 article RU cc-by-nc-nd Diabetes Mellitus 2009-03-15

Aim. To study the intensity of soft tissue repair in patients with diabetic foot syndrome (DFS) during local negative pressure wound treatment versus standard care. Subjects and methods. The investigators estimated clinical (wound sizes, oxygenation), histological (light microscopy), immunohistochemical (CD31, CD68, MMP-9, TIMP-1) markers for reparative processes DFS vacuum therapy Forty-two neuropathic neuroischemic (without critical ischemia) forms were examined after debridement. In...

10.17116/terarkh2016881019-24 article EN Terapevticheskii arkhiv 2016-10-15
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