A5074010317- Oral microbiology and periodontitis research
- Antifungal resistance and susceptibility
- Probiotics and Fermented Foods
- Infective Endocarditis Diagnosis and Management
- Streptococcal Infections and Treatments
- Oral Health Pathology and Treatment
- Salivary Gland Disorders and Functions
- Endodontics and Root Canal Treatments
- Antimicrobial Peptides and Activities
- Bacterial biofilms and quorum sensing
- Fungal Infections and Studies
- Clostridium difficile and Clostridium perfringens research
- Periodontal Regeneration and Treatments
- Otolaryngology and Infectious Diseases
- Microbial Metabolic Engineering and Bioproduction
- Fermentation and Sensory Analysis
- Oral health in cancer treatment
- Oral and gingival health research
- Amino Acid Enzymes and Metabolism
- Herbal Medicine Research Studies
- Herpesvirus Infections and Treatments
- Hippo pathway signaling and YAP/TAZ
- Microbial Metabolites in Food Biotechnology
- Botulinum Toxin and Related Neurological Disorders
- Bacterial Identification and Susceptibility Testing
University of Tennessee at Knoxville
2020-2024
Eastbourne District General Hospital
2008
University of Manchester
1976-2002
Federation University
1997
University Dental Hospital of Manchester
1968-1987
Stepping Hill Hospital
1986
University of Otago
1981
MRC Toxicology Unit
1976
Manchester University
1953-1975
Pilgrim Hospital
1866-1867
The lethal effect on different micro‐organisms of ultrasonic waves and hydrogen peroxide separately in combination was examined. Ultrasonic were able to disintegrate Fusobacterium nucleatum within 3 min kill Veillonella parvula after 15 Streptoccus sanguis 20 min; vols H 2 O (6% w/v) killed V. parvula, Strep. Staphylococcus aureus 5 treatment, Clostridium sporogenes spores 25 min. Sonication Cl. spores, Bacillus cereus Candida albicans , using an probe, the organisms 15, 10 min,...
Candida albicans causes severe invasive candidiasis. C. infection requires the virulence factor candidalysin (CL) which damages target cell membranes. However, mechanism that CL uses to permeabilize membranes is unclear. We reveal forms membrane pores using a unique mechanism. Unexpectedly, readily assembled into polymers in solution. propose basic structural unit polymer formation oligomer, sequentially added string configuration can close loop. loops appear spontaneously insert become...
Long-term candidal infection of the rat's tongue has been found to produce marked epithelial hyperplasia with keratin trapped between folds hyperplastic epithelium. The epithelium showed atypia which did not amount carcinoma in situ. Degenerative changes were superficial layers lingual muscle beneath areas infection, and after a year, hyalinized fibrous tissue appeared replace damaged muscle.
Apparatus which enables the simultaneous continuous monitoring of pH and Eh bacterial dental plaque as it develops on a tooth surface in an artificial mouth is described. Details electrodes used, equipment, culture conditions are given. Preliminary results given showing values produced vitro to be close agreement with readings reported for vivo. The effect incorporation 1% sucrose medium these parameters distinct inverse relationship between recorded.
SUMMARY After being given tetracycline in drinking water (0.1 per cent.) for 5 days, rats were inoculated orally with Candida albicans on three occasions at 2-day intervals. Immediately after the first inoculation, concentration of was reduced to 0.01 cent. and this maintained next 28 days. The rats’ mouths regularly colonised by C. albicans, organism recoverable throughout experiment. Histological examination showed tissues 75 animals. Infection dorsal surface tongue produced a striking...
The impact of the EphA2 receptor on cancer malignancy hinges two different ways it can be activated. induces antioncogenic signaling after ligand binding, but ligand-independent activation is pro-oncogenic. It believed that transmembrane (TM) domain adopts alternate conformations in ligand-dependent and states. However, poorly understood how difference TM helical crossing angles found impacts activity regulation EphA2. We devised a method uses hydrophobic matching to stabilize peptide...
SUMMARY: The vitamin requirements of thirty-four strains lactic acid bacteria, representing ten species and isolated from brewery materials, were studied. Individual required one to four vitamins for normal growth on the basal medium used. Pantothenic was by all organisms. In a number cases failed when groups vitamins, individually non-essential, omitted.
SUMMARY: A new species of heterofermentative Lactobacillus has been isolated from top-fermentation beer in which it oocurs as a contaminant. The organism is distinguished principally by the fact that ferments only glucose, maltose and inulin and, consequence, designated L. malefermentans.
Abstract A survey has been made of a selection the lactic acid bacteria occurring in 12 samples yeast and 9 beer from British breweries. Strains 8 known species were identified these included Lactobacillus buchneri, Lb. bifidus, leichmanii, plantarum Streptococcus cremoris , none which hitherto detected beer. In addition, three rod‐shaped organisms isolated proved to be type cultures new Lactobacillus. Five cocci found related Pediococcus damnosus var. salicinaceus Mees have classified as...
The adhesion to fibrin‐platelet clots in vitro of 21 strains streptococci isolated from the blood patients with sub‐acute bacterial endocarditis (SABE) was measured. species, order greatest adhesion, were Streptococcus faecalis, mutans, milleri, sanguis , dextran‐positive mitior dextran‐negative and salivarius. Individual within however, cannot be assumed representative their species may exhibit unusually high or low adhesion. Adhesion depended upon both concentration period contact. There...
SUMMARY One hundred and twenty six strains of streptococci isolated from the bloodstreams 123 hospital in-patients—55 with endocarditis—and 255 gingival crevices 66 volunteers were characterised. Species Streptococcus mitior, S. sanguis, undifferentiated viridans streptococci, salivarius, milleri, mutans, bovis faecalis. There was no significant difference between distribution species in blood crevice. mitior sanguis found less frequently than their presence crevice would have suggested,...
Quantitative and qualitative examination of anaerobically isolated flora the gingival crevice saliva was carried out. It found that half organisms were anaerobes there twice as many gram-positive gram-negative ones. Rods predominant in (60.5%) cocci (69.1%). Of total organisms, nonsporing, anaerobic rods accounted for 24% 9.7% saliva. These characterized on basis type fatty acids produced from glucose various biochemical reactions. They belonged to following genera: Actinomyces,...
Bacteriocinogenic strains of Streptococcus salivarius antagonized Strep. sanguis on blood agar and in Todd‐Hewitt broth with, but not without, sucrose. Each organism produced plaque vitro but, after a mixed inoculum with both organisms, the numbers rapidly fell to <0.01% organisms. A non‐bacterio‐cinogenic mutant was itself inhibited by plaque‐producing system; derivatives partially resistant bacteriocin plate test nevertheless failed co‐habit bacteriocinogenic salivarius. The latter...
ABSTRACT Isolates of lactic acid bacteria were obtained from non‐dairy fermented foods (Mettwurst salami, Prosciutto ham and black olives). Their species identified they investigated for their ability to produce exopolysaccharides. A reference yoghurt culture ( Streptococcus thermophilus ) an exopolysaccharide producing isolate Leuconostoc mesenteroides ‐ Isolate 3) grown in mESM broth under aerobic conditions at 25°C. They produced up 600 mg/L 530 exopolysaccharide, respectively....
The pH and E h of bacterial plaques produced on a tooth surface in an artificial mouth following inoculation with saliva, single cultures mixed were measured. importance these properties the role sucrose controlling colonization by specific organisms, particularly anaerobes, was investigated. degree estimated from viable counts effluent tooth. Interactions between species multi‐culture are discussed. results presented support hypothesis that teeth anaerobes depends upon prior growth aerobes...
The results of two experiments in which the mouths germ-free and conventionalized specific pathogen-free rats, some had been treated with tetracycline hydrochloride, were inoculated C. albicans are reported. state favours carriage infectivity fungus to such a degree that any complementary action was not demonstrated present experiments. Carriage less prevalent whom potentiated both infectivity. In first experiment an incidental finding unusual form gingivitis Candida infected probably due...