A5038765631- Dialysis and Renal Disease Management
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Retinal Diseases and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Muscle Physiology and Disorders
- Electrospun Nanofibers in Biomedical Applications
- Retinopathy of Prematurity Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Chronic Kidney Disease and Diabetes
- Connective Tissue Growth Factor Research
- Renal and Vascular Pathologies
- Biomarkers in Disease Mechanisms
- Acute Kidney Injury Research
- Retinal Imaging and Analysis
- Systemic Sclerosis and Related Diseases
- Bone Tissue Engineering Materials
- Cardiovascular Issues in Pregnancy
- COVID-19 and healthcare impacts
- Neurological Complications and Syndromes
- Corneal Surgery and Treatments
- Angiogenesis and VEGF in Cancer
- Blood donation and transfusion practices
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2019-2022
University of Groningen
2017-2020
University Medical Center Groningen
2015-2020
University of Brescia
2018-2020
Heidelberg University
2017-2018
Cells Therapy (Poland)
2018
University Hospital Heidelberg
2017-2018
University Medical Centre Mannheim
2017-2018
StemCells (United States)
2018
The SARS-CoV-2 epidemic is pressuring healthcare systems worldwide. Disease outcomes in certain subgroups of patients are still scarce, and data needed. Therefore, we describe here the experience four dialysis centers Brescia Renal COVID Task Force. During March 2020, within an overall population 643 hemodialysis patients, RNA positivity was detected 94 (15%). At disease diagnosis, 37 (39%) (group 1) were managed on outpatient basis, whereas remaining 57 (61%) 2) required hospitalization....
The outcome of kidney transplant patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is still unclear. Here we describe the clinical characteristics, disease outcome, and risk factors for distress (ARDS) death a cohort 53 2019 (COVID-19). Eight have been handled as outpatients because mild disease, on average immunosuppression reduction addition hydroxychloroquine azithromycin; no required admission, developed ARDS, or died. Because symptoms, 45/53 admission:...
Decellularized-organ-derived extracellular matrix (dECM) has been used for many years in tissue engineering and regenerative medicine. The manufacturing of hydrogels from dECM allows to make use the pro-regenerative properties ECM and, simultaneously, shape material any necessary way. objective present project was investigate differences between cardiovascular tissues (left ventricle, mitral valve, aorta) with respect generating their interaction cells 2D 3D. left aorta porcine hearts were...
Long-term diabetes leads to macrovascular and microvascular complication. In diabetic retinopathy (DR), persistent hyperglycemia causes permanent loss of retinal pericytes aberrant proliferation endothelial cells (ECs). Adipose tissue-derived stromal (ASCs) may serve functionally replace normalize microvasculature during disease progression. We hypothesized that Notch signaling in ASC underlies regulation stabilization dysfunctional networks such as DR. prominently constitutively expressed...
To analyze the results of an outpatient clinic with a multidisciplinary team and educational support for patients late-stage CKD (lsCKD), to check its possible effect on their outcomes.Longitudinal cohort study followed up in MaReA (Malattia Renale Avanzata = CKD5) at ASST Spedali Civili Brescia from 2005 2015 least six months. Trajectory renal function over time has been evaluated only those four estimations eGFR before referring MaReA.Seven hundred were enrolled, mean age was 72 ± 14...
Introduction: Pericyte loss in the retina is an early microvascular complication diabetes patients. To date, ADSC (adipose-derived stromal cells) have been shown to resemble pericyte activity and phenotype. However, little known about molecular mechanisms controlling ADSC-endothelial cells communication. In this study, we hypothesized that Notch signaling contributes homeostasis stabilization of retinal endothelial diabetic retinopathy.
Abstract Background and Aims Encapsulating peritoneal sclerosis (EPS) is a rare but severe complication of dialysis (PD). Its prevalence, ranging from 0.7 to 3.3%, its reported mortality 25-55%. Post-transplantation encapsulating (PT-EPS) usually occurs within two years PD interruption due kidney transplantation. Calcineurin inhibitors are thought be involved in the pathogenesis PT-EPS. Method This retrospective, single-center study: all patients who received for 2 or more months before...
Figure: Background and Aims in Italy only a minority of uremic patients perform peritoneal dialysis (PD). In centers where PD is practiced proposed the prevalence no more than 23%. Proposed advantages over HD are preserved Residual renal function (RRF), that has been associated with better survival, Quality life (Qol) due to possible preservation previous lifestyle, independence, possibility traveling, flexibility. Incremental promising way further improve Qol preserve RRF. Lastly, less...