A5028291087- Extracellular vesicles in disease
- Cardiovascular Disease and Adiposity
- Atherosclerosis and Cardiovascular Diseases
- MicroRNA in disease regulation
Lund University
2021-2022
We investigated how microvesicles (MVs) from patients with cardiovascular diseases are related to coronary flow reserve (CFR), a clinical parameter reflecting blood in the heart. Our results show negative relationship between CFR and levels of platelet endothelial MVs. The pattern MV-enriched biomarkers differs high low CFR. findings suggest potential value MVs as reduced proatherogenic status, additional
Abstract Background Endothelial and microvascular dysfunction are pivotal causes of major adverse cardiac events predicted by coronary flow reserve (CFR). Extracellular Vesicles (EVs) have been studied extensively in the pathophysiology artery disease. However, little is known on impact non-coding RNA content EVs with respect to CFR. Methods We carried out a study among 120 patients divided high-CFR low-CFR profile miRNA circulating EVs. Results A multiplex array profiling revealed...