A5046733966- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- Peptidase Inhibition and Analysis
- Sulfur-Based Synthesis Techniques
- Plant-Microbe Interactions and Immunity
- Chemical synthesis and alkaloids
- Plant Parasitism and Resistance
- Legume Nitrogen Fixing Symbiosis
- Advanced Synthetic Organic Chemistry
Rice University
2018-2021
Dissolved organic carbon in soils can repress flavonoid bioavailability and disrupt plant nodulation.
Metal-based bioconjugation linkages represent a little-studied approach to protein functionalization that provides novel reactivity, stability, and function. Described is an organometallic bioconjugation, employing rhodium(III) salts, link boronic acids with tyrosine residues by arene complex. Both peptides proteins are amenable the mild in aqueous media, allowing incorporation of useful functionalities, such as affinity handles or fluorophores. Because metastability inorganic linkage,...
Nickel salts catalyze fast cysteine arylation with 2-nitroarylboronic acids. The process uses cheap, readily-available reagents and allows introduction of diverse chemical handles.
The discovery of unique Chan-Lam coupling reactivity arylboronic acids containing an <italic>ortho</italic>-sulfonamide group allows site-specific tailoring peptide structure.
Small and simple bioorthogonal reactive handles that can be readily encoded by natural processes are important for bioconjugation. A rapid nickel-promoted N-H arylation of pyroglutamate-histidine sequences with 2-nitroarylboronic acids proceeds under mild aqueous conditions. Chemoselective activation a lactam amide within peptide or protein provides new approach to selective conjugation in polyamide structures.
Boronic acids can play diverse roles when applied in biological environments, and employing boronic acid structures tandem could provide new tools for multifunctional probes. This Letter describes a pair of functional groups, 2-nitro-arylboronic (NAB) (E)-alkenylboronic (EAB), that enable sequential cross-coupling through stepwise nickel- copper-catalyzed processes. The selective coupling NAB groups enables the preparation stapled peptides, protein-protein conjugates, other bioconjugates.
Abstract Metal‐based bioconjugation linkages represent a little‐studied approach to protein functionalization that provides novel reactivity, stability, and function. Described is an organometallic bioconjugation, employing rhodium(III) salts, link boronic acids with tyrosine residues by arene complex. Both peptides proteins are amenable the mild in aqueous media, allowing incorporation of useful functionalities, such as affinity handles or fluorophores. Because metastability inorganic...
Abstract Transition‐metal catalysis provides new approaches to selectivity and the activation of otherwise inert functional groups. Bioconjugation with protein peptide substrates presents numerous challenges group selectivity, transitional‐metal provide important alternative solutions these challenges. This article describes development boronic acid reagents for selective modification peptides proteins, focusing primarily on catalytic C−X bond formation.