A5056914848- Genomic variations and chromosomal abnormalities
- Carcinogens and Genotoxicity Assessment
- Chromosomal and Genetic Variations
- DNA Repair Mechanisms
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Insect behavior and control techniques
- Bladder and Urothelial Cancer Treatments
- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- Silkworms and Sericulture Research
- Sperm and Testicular Function
- Plant Genetic and Mutation Studies
- Renal and related cancers
- Animal Genetics and Reproduction
- Renal cell carcinoma treatment
- Effects of Radiation Exposure
- Genetic diversity and population structure
- Lymphoma Diagnosis and Treatment
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Prenatal Screening and Diagnostics
- RNA modifications and cancer
- Urinary and Genital Oncology Studies
- Acute Lymphoblastic Leukemia research
- Genomics and Rare Diseases
Universitat Autònoma de Barcelona
2005-2019
National Institutes of Health
2017
National Cancer Institute
2017
Hospital Universitari Arnau de Vilanova
2009
Universitat de Lleida
2009
Universidad Nacional Autónoma de México
1996-2004
Mexican Institute of Petroleum
2003
Instituto Nacional de Investigaciones Nucleares
1983-2003
Duran i Reynals Hospital
2001
Universitat de Barcelona
1992-1999
The in vitro pretreatment of phytohaemagglutinin stimulated human lymphocytes with tritiated thymidine or low doses X-rays induces a response that makes these cells less susceptible to further genetic damage induced by subsequent high radiation. This phenomenon has been called 'Adaptive Response' because it is similar the one described E. coli. In present study, we describe irradiated at 2 Gy, from individuals occupationally exposed X and γ rays, show lower frequencies dicentrics than those...
Gene arrangement frequencies were determined at two stages in the life history of Drosophila pseudoobscura taken from nature. Three populations central highlands Mexico each sampled twice during 1976. measured adult males and larvae that offspring females collected same time. The all likelihood a representative sample those who fathered produced by wild females. Differences gene frequency between these should indicate operation natural selection. One-third our comparisons common next...
Abstract Gene amplification is one of the most frequent manifestations genomic instability in human tumors and plays an important role tumor progression acquisition drug resistance. To better understand factors involved acquired resistance to cytotoxic drugs via gene amplification, we have analyzed structure dynamics dihydrofolate reductase (DHFR) HT29 cells treated with methotrexate (MTX). Analysis DHFR process shows that amplicon exhibits a complex consistently reproduced independent...
Genomic copy number changes are frequently found in cancers and they have been demonstrated to contribute carcinogenesis; it is widely accepted that tumors with microsatellite instability (MSI) genetically stable mostly diploid. In the present study we compared alterations gene-expression profiles of (MSS) MSI colorectal tumors. A total 31 fresh-frozen primary (16 MSS 15 MSI) were used. Twenty-eight samples (15 13 analyzed metaphase comparative genomic hybridization (CGH), nine which plus...
The frequency of multiple insemination was studied in female D. pseudoobscura from a Mexican population. This population highly polymorphic for third chromosome gene arrangements, and simple inspection the progeny single females showed that at least 43% them carried sperm two or more males. number distinct arrangements used to estimate total inseminations according probabilistic model. double estimated lie between 60% 100%, while triple quadruple were be quite rare. Double clearly rule, not...
Journal Article POPULATION GENETICS OF MEXICAN DROSOPHILA VI. CYTOGENETIC ASPECTS THE INVERSION POLYMORPHISM IN PSEUDOOBSCURA Get access O. Olvera, Olvera Search for other works by this author on: Oxford Academic Google Scholar J. R. Powell, Powell M. E. de la Rosa, Rosa V. Salceda, Salceda I. Gaso, Gaso Guzman, Guzman W. Anderson, Anderson L. Levine Evolution, Volume 33, Issue 1Part2, 1 March 1979, Pages 381–395, https://doi.org/10.1111/j.1558-5646.1979.tb04691.x Published: 01 1979 history...
The accumulation of multiple chromosomal abnormalities is a characteristic the majority colorectal cancers and has been attributed to an underlying instability. Genetic instability considered have key role in generation genetic phenotypic heterogeneity cancer cells. To shed light on dynamics colon cells, we analyzed divergence clonal subclonal derivates chromosomally unstable (SW480) stable (HCT116, LoVo) cell lines. Conventional G-banding karyotyping arbitrarily primed PCR (AP-PCR)...
Most tumors show abnormal karyotypes involving either chromosome rearrangements and/or aneuploidies. The aim of our study is to measure the rate both structural and numerical instability in two colorectal cancer cell lines: HCT116, SW480 its single subclones. To determine instability, we measured nonclonal alterations last division by means multicolor-fluorescence situ hybridization (FISH). quantify used centromere-specific DNA probes simultaneously detect loss nondisjunctional events...
Abstract Colorectal cancer (CRC) mostly develops from a variety of polyps following mainly three different molecular pathways: chromosomal instability (CIN), microsatellite (MSI) and CpG island methylation (CIMP). Polyps are classified histologically as conventional adenomas, hyperplastic polyps, sessile serrated adenomas/polyps (SSA/P) traditional adenomas (TSA). However, the association these with types CRCs underlying genetic epigenetic aberrations has yet to be resolved. In order address...
Abstract Mantle cell lymphoma (MCL) is genetically characterized by 11q13 translocations leading to the overexpression of CCND1, and additional secondary genomic alterations that may be important in progression this disease. We have analyzed 22 MCL cases 10 lines using multicolor fluorescence situ hybridization (M‐FISH), FISH, comparative (CGH). The 19 with abnormal karyotype showed t(11;14)(q13;q32) translocation and, additionally, 89% both numerical ( n = 58) structural 77) aberrations....
So far, CRC cell lines have contributed to descriptions of 2 patterns genetic instability, affecting either microsatellite sequences or chromosome number and structure. Often, these are mutually exclusive; while near-diploid karyotypes usually appear with MSI chromosomal stability, near-triploid tetraploid cells display a high degree CIN stable at the level. In present study, we describe genomic instability pattern KM12 cells. KM12C derived different metastatic properties were analyzed by...
Sperm chromosome studies have shown that patients treated with chemotherapy for testicular cancer a much higher incidence of abnormalities than other types or controls. In two out four cases, penetration zona-free hamster eggs was close to zero, indicating after 2–7 years treatment the functional capacity sperm had not been recuperated. The cytogenetic study spermatozoa shows many observed corresponded structural aberrations may pathogenic effect in production abortions children abnormalities.