A5045903014- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Tumors and Oncological Cases
- RNA modifications and cancer
- Head and Neck Surgical Oncology
- Ear and Head Tumors
- Cancer-related gene regulation
- Lung Cancer Diagnosis and Treatment
- Congenital Heart Disease Studies
- Fuzzy Logic and Control Systems
- Lung Cancer Treatments and Mutations
- Ocular Surface and Contact Lens
- Management of metastatic bone disease
- Cancer Research and Treatments
- Molecular Biology Techniques and Applications
- Advanced Control Systems Optimization
- Cardiovascular Function and Risk Factors
- ECG Monitoring and Analysis
- Genetic factors in colorectal cancer
- Cerebral Venous Sinus Thrombosis
- Cardiovascular and Diving-Related Complications
- Hepatocellular Carcinoma Treatment and Prognosis
- Bladder and Urothelial Cancer Treatments
- Oral and Maxillofacial Pathology
- Beetle Biology and Toxicology Studies
University of Tokyo Hospital
2024
Keio University
2024
The University of Tokyo
2024
Yokohama City University
2014-2023
Yokohama City University Medical Center
2023
Yokosuka Kyosai Hospital
2016
Kanagawa Prefectural Hospital Organization
2014-2015
Kanagawa Cancer Center
2014-2015
University of the Ryukyus University Hospital
1988
Background Convolutional neural networks (CNNs) have emerged as a novel method for evaluating heart failure (HF) in adult electrocardiograms (ECGs). However, such CNNs are not applicable to pediatric HF, where abnormal anatomy of congenital defects plays an important role. ECG-based reflecting neurohormonal activation (NHA) may be useful marker HF. This study aimed develop and validate ECG-derived HF that reflects the risk future cardiovascular events. Methods Based on 21,378 ECGs from 8324...
To generate a reliable preclinical model system exhibiting the molecular features of salivary adenoid cystic carcinoma (ACC) whose biology is still unclear due to paucity stable cell cultures. develop new in vitro and vivo models ACC, techniques organoid culture patient-derived tumor xenograft (PDX), which have attracted attention other malignancies recent years, were applied. Tumor specimens from surgically resected ACC proceeded for preparation PDX culture. The orthotopic transplantation...
Background/Aim: We evaluated the impact of FosL1, a member activated protein-1 family, on pathways leading to regional metastasis head and neck squamous cell carcinoma (HNSCC). Materials Methods: examined influence small interfering RNA (siRNA) short heparin (shRNA) mediated knockdown FosL1 migration, invasion, proliferation in vitro as well vivo. The prognostic significance was also analyzed using Kaplan– Meier plotter data from an HNSCC patient database. Results: Down-regulation inhibited...
Complete transposition of the great arteries (TGA) represents complex and unique circulation that is dependent on blood mixing through multiple interacting shunts. Consequently, role each shunt treatment strategy remain unclear. We developed a mathematical model TGA circulation, revealing significant influence atrial septal defect (ASD) oxygenation hemodynamics. The flow pattern ASD reflects its hemodynamic impact helps determine strategies.
Summary Palpebral conjunctival hue alteration is used in non‐invasive screening for anaemia, whereas it a qualitative measure. This study constructed machine/deep learning models predicting haemoglobin values using 150 palpebral images taken by smartphone. The median value was 13.1 g/dL, including 10 patients with <11 g/dL. A segmentation model U‐net successfully constructed. segmented were subjected to non‐convolutional neural network (CNN)‐based and CNN‐based regression values....
2003年4月から2014年3月までの11年間に横須賀共済病院にて根治治療を行った下咽頭癌症例の治療成績を検討し,今後の課題を考察した。対象は前治療のない下咽頭扁平上皮癌症例76例である。観察期間中央値は60ヶ月(1~132ヶ月),男性67例,女性9例,年齢は中央値66歳(44~99歳)だった。臨床病期は,stage I/II/III/IV:3/10/10/53例であった。一次治療として手術治療または化学療法併用放射線療法(Concurrent chemoradiotherapy:CCRT)を行った。喉頭温存希望症例には,術前導入化学療法 (Neoadjuvant chemotherapy:NAC)...
唾液腺導管癌（salivary duct carcinoma：SDC）は，浸潤性乳管癌に類似した組織像を呈する高悪性度の腫瘍で，非常に予後不良な腫瘍と報告されている。今回，耳下腺原発のSDCに対する根治的手術，術後化学放射線療法，補助化学療法を含めた集学的治療の成績について検討した。対象は2003年9月から2011年3月までの間に当科で治療した耳下腺原発のSDC7症例（stageI: 1例，II: 1例，IVa：5例）である。切除断端に十分な安全域を設けた腫瘍切除を行い，stageIVa症例には根治的頸部郭清術を併施した。更に全例で術後に化学放射線療法および補助化学療法を施行した。5年粗生存率は83.3%であり，根治的手術，術後化学放射線療法，補助化学療法を含めた集学的治療で良好な予後が得られる可能性が示唆された。
This study aimed to identify key molecules associated with the survival of patients hypopharyngeal squamous cell carcinoma (HpSCC) by combining in silico and vitro analyses.Differentially expressed genes (DEGs) were screened using Gene Expression Omnibus database. For DEGs, we performed functional enrichment protein-protein interaction network analyses potential biological functions hub genes. Functional analysis HpSCC lines verified critical roles genes.DEGs extracellular matrix. Among...
Background: The purpose of this study was to elucidate the efficacy concurrent chemotherapy and analyze prognostic factors in radiation-based therapy for early stage laryngeal squamous cell carcinoma (ELSCC). Methods: records 97 patients with ELSCC treated by from 2004 2016 were retrospectively reviewed. Eighty-one combined-agent regimens during treatment. Of 81 patients, 58 S-1 regimen 23 other regimens. Clinical factors, such as chemotherapy, non-glottic subsite incidence second primary...