A5091503209- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Memory and Neural Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Autism Spectrum Disorder Research
- Virus-based gene therapy research
- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA Interference and Gene Delivery
- Retinal Development and Disorders
- Neuroscience and Neural Engineering
- Neurogenesis and neuroplasticity mechanisms
- Genetics and Neurodevelopmental Disorders
Australian National University
2019-2024
The University of Queensland
2024
The central nervous system's limited capacity for regeneration often leads to permanent neuronal loss following injury. Reprogramming resident reactive astrocytes into induced neurons at the site of injury is a promising strategy neural repair, but challenges persist in stabilizing and accurately targeting viral vectors transgene expression. In this study, we employed bioinspired self-assembling peptide (SAP) hydrogel precise controlled release hybrid adeno-associated virus (AAV) vector,...
Interneurons are fundamental cells for maintaining the excitation-inhibition balance in brain health and disease. While interneurons have been shown to play a key role pathophysiology of autism spectrum disorder (ASD) adult mice, little is known about how their maturation altered developing striatum ASD. Here, we aimed track striatal elucidate molecular physiological alterations Cntnap2 knockout mouse model. Using Stereo-seq single-cell RNA sequencing data, first characterized pattern...
The molecular mechanisms tuning cholinergic interneuron (CIN) activity, although crucial for striatal function and behavior, remain largely unexplored. Previous studies report that the Etv1/Er81 transcription factor is vital regulating neuronal maturation activity. While Er81 known to be expressed in striatum during development, its specific role defining CIN properties resulting consequences on unknown. We here CINs ablation leads prominent changes their molecular, morphologic,...
SUMMARY The finely-tuned activity of cholinergic interneurons (CINs) in the striatum is key for motor control, learning, and habit formation. Yet, molecular mechanisms that determine their unique functional properties remain poorly explored. Using a combination genetic biochemical assays, vitro vivo physiological characterisation, we report selective ablation Er81 transcription factor leads to prominent changes CIN molecular, morphological electrophysiological features. In particular, lack...
Abstract A rising concern in Autism Spectrum Disorder (ASD) is the heightened sensitivity to stress and trauma, potential consequences of which have been overlooked, particularly upon severity ASD traits. This study investigated predisposition to, impact of, Post-Traumatic Stress (PTSD) ASD. We first demonstrated a reciprocal relationship between two disorders revealed that exposure mild stressful event induces PTSD-like memory four mouse models also establish an unanticipated consequence...