A5030463641- Memory and Neural Mechanisms
- Neurobiology and Insect Physiology Research
- Invertebrate Immune Response Mechanisms
- Stress Responses and Cortisol
- Anesthesia and Neurotoxicity Research
- Neuroscience and Neuropharmacology Research
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Animal Behavior and Reproduction
- Neuroinflammation and Neurodegeneration Mechanisms
- Insect Utilization and Effects
- Memory Processes and Influences
- Trace Elements in Health
- Neural dynamics and brain function
- RNA and protein synthesis mechanisms
- Insect Resistance and Genetics
- Circadian rhythm and melatonin
- Estrogen and related hormone effects
- Child and Adolescent Psychosocial and Emotional Development
Neurocentre Magendie
2016-2024
Inserm
2016-2024
Université de Bordeaux
2010-2024
Institut de Neurosciences Cognitives et Intégratives d’Aquitaine
2015-2016
Centre National de la Recherche Scientifique
2010-2016
Feeding and sleep are fundamental behaviours with significant interconnections cross-modulations. The circadian system peptidergic signals important components of this modulation, but still little is known about the mechanisms networks by which they interact to regulate feeding sleep. We show that specific thermogenetic activation Allatostatin A (AstA)-expressing PLP neurons enteroendocrine cells reduces promotes in fruit fly Drosophila. effects AstA cell mediated peptides receptors homolog...
Abstract Post-traumatic stress disorder (PTSD) is characterized by emotional hypermnesia on which preclinical studies focus so far. While this relates to salient traumatic cues, partial amnesia for the context can also be observed. Here, we show in mice that contextual causally involved PTSD-like memory formation, and treating re-exposure all trauma-related cues cures hypermnesia. These findings open a therapeutic perspective based trauma contextualization underlying hippocampal mechanisms.
Temporal binding, the process that enables association between discontiguous stimuli in memory, and relational organization, a flexibility of declarative memories, are both hippocampus-dependent decline aging. However, how these two processes related supporting memory formation they compromised age-related loss remain hypothetical. We here identify causal link features memory: binding is necessary condition for organization events. demonstrate limited by capability temporal which depends on...
A rising concern in autism spectrum disorder (ASD) is the heightened sensitivity to trauma, potential consequences of which have been overlooked, particularly upon severity ASD traits. We first demonstrate a reciprocal relationship between and post-traumatic stress (PTSD) reveal that exposure mildly stressful event induces PTSD-like memory four mouse models ASD. also establish an unanticipated consequence stress, as formation leads aggravation core autistic Such susceptibility developing...
The Drosophila ATP7 copper transporter has sequence homology to the human transporters ATP7A and ATP7B, which are defective in Menkes Wilson disease, respectively. We show here that is expressed by many peptidergic neurons. As C‐terminal amidation of neuropeptides depends on copper‐containing enzyme PHM, it seemed likely absence activity PHM might be compromised. Indeed, inhibition expression RNAi led a decrease mature amidated appearance C‐terminally Gly‐extended neuropeptides. strength...
Abstract GluN2B subunits of NMDA receptors have been proposed as a target for treating age‐related memory decline. They are indeed considered crucial hippocampal synaptic plasticity and hippocampus‐dependent formation, which both altered in aging. Because enrichment is associated with LTP vitro, similar mechanism expected to occur during formation. We show instead that reduction localization induced by single‐session learning dorsal CA1 apical dendrites predictive efficient memorization...
One of the cardinal features post-traumatic stress disorder (PTSD) is a paradoxical memory alteration including both emotional hypermnesia for salient trauma-related cues and amnesia surrounding traumatic context. Interestingly, some clinical studies have suggested that contextual would causally contribute to PTSD-related insofar as decontextualized, prone be reactivated in contexts can very different from original However, most current animal models focus exclusively on hypermnesia, i.e.,...
Declarative memory formation depends on the hippocampus and declines in aging. Two functions of hippocampus, temporal binding relational organization (Rawlins Tsaltas, 1983; Eichenbaum
Abstract Recalling a specific past episode that will enable us to decide which action is suited given present situation core element of everyday life. A wealth research has demonstrated such selective remembering dependent upon capacity inhibit or provisionally ‘forget’ related yet inappropriate memory episodes could orient behavior in unwilled directions. Everyday-like (EdM) refers this type common organizational mnemonic capacity, known deteriorate significantly with age, putatively as...
Abstract A rising concern in Autism Spectrum Disorder (ASD) is the heightened sensitivity to stress and trauma, potential consequences of which have been overlooked, particularly upon severity ASD traits. This study investigated predisposition to, impact of, Post-Traumatic Stress (PTSD) ASD. We first demonstrated a reciprocal relationship between two disorders revealed that exposure mild stressful event induces PTSD-like memory four mouse models also establish an unanticipated consequence...