A5048862309- RNA Research and Splicing
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- PARP inhibition in cancer therapy
- Genomics and Chromatin Dynamics
- Nuclear Structure and Function
- Heat shock proteins research
- Health and Medical Research Impacts
- Helicobacter pylori-related gastroenterology studies
- Advanced Biosensing Techniques and Applications
- Trace Elements in Health
- Science, Research, and Medicine
- Circular RNAs in diseases
- Monoclonal and Polyclonal Antibodies Research
- Advances in Oncology and Radiotherapy
The Nature Conservancy
2021-2025
University of Bath
2017-2022
University of Essex
2017-2018
Article16 April 2018Open Access Source DataTransparent process The long non-coding RNA Paupar promotes KAP1-dependent chromatin changes and regulates olfactory bulb neurogenesis Ioanna Pavlaki orcid.org/0000-0003-2514-0977 Department of Biology Biochemistry, University Bath, UK Search for more papers by this author Farah Alammari Physiology, Anatomy Genetics, Oxford, Bin Sun Neil Clark MRC Human Genetics Unit, Institute Molecular Medicine, Western General Hospital, Edinburgh, Tamara Sirey...
CTCF is an evolutionarily conserved and ubiquitously expressed architectural protein regulating a plethora of cellular functions via different molecular mechanisms. can undergo number post-translational modifications which change its properties functions. One such linked to cancer poly(ADP-ribosyl)ation (PARylation). The highly PARylated form has apparent mass 180 kDa (referred as CTCF180), be distinguished from hypo- non-PARylated with the 130 CTCF130). existing data accumulated so far have...
Central nervous system-expressed long non-coding RNAs (lncRNAs) are often located in the genome close to protein coding genes involved transcriptional control. Such lncRNA-protein gene pairs frequently temporally and spatially co-expressed system predicted act together regulate neuronal development function. Although some of these lncRNAs also bind modulate activity encoded transcription factors, regulatory mechanisms controlling co-expression neighbouring remain unclear. Here, we used high...
Abstract CTCF is an evolutionarily conserved and ubiquitously expressed architectural protein regulating a plethora of cellular functions via different molecular mechanisms. can undergo number post-translational modifications which change its properties functions. One such linked to cancer poly(ADP-ribosyl)ation (PARylation). The highly PARylated form has apparent mass 180 kDa (referred as CTCF180), be distinguished from hypo- non-PARylated with the 130 CTCF130). existing data accumulated so...
ABSTRACT Many long non-coding RNAs (lncRNAs) are expressed during central nervous system (CNS) development, yet their in vivo roles and molecular mechanisms of action remain poorly understood. Paupar , a CNS lncRNA, controls neuroblastoma cell growth by binding modulating the activity genome-wide transcriptional regulatory elements. We show here that transcript directly binds KAP1, an essential epigenetic protein, thereby regulates expression shared target genes important for proliferation...
Abstract Central nervous system-expressed long non-coding RNAs (lncRNAs) are often located in the genome close to protein coding genes involved transcriptional control. Such lncRNA-protein gene pairs frequently temporally and spatially co-expressed system predicted act together regulate neuronal development function. Although some of these lncRNAs also bind modulate activity encoded transcription factors, regulatory mechanisms controlling co-expression neighbouring remain unclear. Here, we...